Linoleic acid–rich oil versus blended oil for adults with insulin resistance

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In a single-blind, randomized, parallel-group intervention, adults with insulin resistance will be assigned to take either a linoleic acid–rich oil supplement or a control blended oil each day for 8 weeks while keeping their usual diet and lifestyle. The main outcome is change in insulin resistance measured by HOMA-IR, with secondary outcomes including fasting glucose and insulin, lipid profile, inflammatory and oxidative stress markers, and body composition. Participants are adults aged 20–60 with HOMA-IR > 2.6 and at least one cardiometabolic risk factor, and people with diabetes, prior cardiovascular disease, or on certain medications are excluded. The trial is conducted at a single clinical research center and aims to provide controlled randomized data on the metabolic effects of increasing dietary linoleic acid.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Men and women aged 20 to 60 years.
* Insulin resistance (HOMA-IR \> 2.6).
* At least one cardiometabolic risk factor: abdominal obesity (waist circumference \> 90 cm in men or \> 80 cm in women); low HDL-cholesterol (\< 40 mg/dL in men or \< 50 mg/dL in women); elevated LDL-cholesterol (\> 70 / 100 / 130 mg/dL, according to estimated cardiovascular risk); or elevated blood pressure (≥ 130/85 mmHg).

Exclusion Criteria:

* Diabetes diagnosis.
* Severe psychiatric illness.
* Malabsorption disorders or previous bariatric surgery.
* Pregnancy or lactation.
* Previous clinical cardiovascular disease.
* Regular use of medications that could influence study outcomes, including:

lipid-lowering agents insulin sensitizers antihypertensive drugs anticoagulants antiretroviral therapy thyroid hormones oral corticosteroids immunosuppressants polyunsaturated fatty acid (PUFA) supplements.

* Fasting serum triglycerides ≥ 500 mg/dL or LDL-cholesterol ≥ 190 mg/dL.
* Body mass index (BMI) ≥ 35 kg/m².
* Very high blood pressure.
* Any additional condition that may limit adherence to the study.

Where it's running

• Centro de Investigaciones Clínicas UC (CICUC) - Pontificia Universidad Católica de Chile
  Santiago, Santiago Metropolitan, Chile Recruiting

Study contacts

• Principal investigator: Loni Berkowitz, PhD — Pontificia Universidad Catolica de Chile
• Study coordinator: Loni Berkowitz, PhD
• Email: lberkowi@uc.cl
• Phone: 23543862

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.