Evaluating the best time for resistance exercise to improve insulin sensitivity and sleep
Official title: Timing (AM v PM) of Acute Resistance Exercise on Glycemic Control in Older Adults: The Acute T-Rex Study
Run by University of Utah · NCT06366399 · Data updated 2026-11-12
This study is testing whether doing resistance exercises in the morning or evening helps people aged 50-74 with overweight or obesity improve their insulin sensitivity and sleep quality.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 50 Years to 74 Years |
| Sex | All |
| Enrollment | 20 (estimated) |
| Sponsor | University of Utah Academic / other |
| Locations | 1 site (Salt Lake City, Utah) |
| Status | Recruiting |
| Started | November 15, 2023 |
| Main results expected | December 31, 2025 |
| Study ends | December 31, 2025 |
| Registry record updated | April 3, 2025 |
| Trial ID | NCT06366399 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are men and women aged 50-74 years with a BMI between 25 and 45 kg/m² who are generally healthy and not meeting recommended activity guidelines.
✕Probably not a fit
Patients with uncontrolled cardiovascular or metabolic diseases, sleep disorders, or those currently on weight loss medications may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to determine whether morning or evening resistance exercise has different effects on insulin sensitivity and sleep quality in individuals aged 50-74 with overweight or obesity. Participants will engage in a randomized cross-over trial, performing resistance exercises at two different times of the day in a controlled laboratory setting. Each session will be followed by overnight sleep and an oral glucose tolerance test the next day. The hypothesis is that evening exercise may yield greater benefits for insulin sensitivity compared to morning exercise.
Why it matters
Potential benefit: If successful, this study could help identify optimal exercise timing to improve insulin sensitivity and reduce the risk of Type 2 Diabetes Mellitus.
How similar studies have gone: While the specific timing of resistance exercise has not been extensively studied, previous research has shown that exercise timing can influence metabolic outcomes, suggesting potential for success in this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Men and women, all ethnicities, aged 50-74 years * BMI ≥25 kg/m² and \<45 kg/m² * Weight stable (less than 5% change in the past 6 months) * Generally healthy individuals * Not meeting recommended activity guidelines for aerobic or resistance exercise Exclusion Criteria: * Uncontrolled cardiovascular, metabolic, renal, or pulmonary disease * Cancer treatment in the past 5 years * Untreated thyroid disease or other medical conditions affecting weight or energy metabolism * Current use of weight loss medication or other medications likely to impact energy balance * Bariatric surgery or extensive bowel resection in the past 2 years * Current or recent history (past 2 years) of eating disorder * Diagnosis of insomnia, sleep apnea, or other sleep and circadian disorders * Non-English speaking * HbA1c \>6.5%
Where it's running
-
University of Utah HPER E Buildling
Salt Lake City, Utah, United States Recruiting
Study contacts
- Study coordinator: Tanya M Halliday, PhD
- Email: tanya.halliday@utah.edu
- Phone: 801-213-1364
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.