Investigating how insulin resistance and inflammation contribute to Alzheimer's disease
Official title: Role of Peripheral Insulin Resistance and Inflammation in Alzheimer’s Disease
Funded at Univ of Massachusetts Med Sch Worcester · NIH-11167866 · Data updated 2026-11-12
This study is looking at how problems with insulin and inflammation might be connected to Alzheimer's disease, and it aims to find out if issues in the liver play a role, which could help us discover new ways to treat Alzheimer's.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project start | August 15, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $738,843 |
| NIH project number | 5R01AG085308-02 |
| Project ID | NIH-11167866 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with Alzheimer's disease or those at risk due to metabolic dysfunction, particularly those with conditions like metabolic dysfunction-associated steatotic liver disease.
✕Less likely to help
Patients without Alzheimer's disease or significant metabolic dysfunction may not benefit from this research.
What this research studies
This research explores the connection between insulin resistance, inflammation, and Alzheimer's disease (AD). It focuses on understanding how metabolic dysfunction, particularly in the liver, may influence the development of AD. The study will examine the role of specific immune cells and inflammatory markers in both conditions, using animal models to uncover the underlying mechanisms. By identifying these links, the research aims to provide insights that could lead to new therapeutic strategies for AD.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that target insulin resistance and inflammation to slow or prevent the progression of Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in understanding the links between metabolic disorders and neurodegenerative diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Univ of Massachusetts Med Sch Worcester
Worcester, United States Active
Researchers
- Principal investigator: Kim, Jason K — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Kim, Jason K
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.