Condition

Metabolic Disease clinical trials and research

• 51Clinical trials
• 48NIH research projects
• 17Countries

Newest Metabolic Disease clinical trials

All recruiting trials (51)

• CTX310 for refractory high triglycerides or LDL cholesterol

  This trial will test whether a single IV dose of CTX310 is safe and tolerated in adults whose high triglycerides or LDL cholesterol have not responded to available treatments.

  Recruiting at 16 sites Phase 1 CRISPR Therapeutics · Hialeah, Florida and 16 other locations · NCT07491172

• Safety and tolerability of SNS851 in healthy adults.

  This study will test whether a new injectable drug called SNS851 is safe and well-tolerated when given under the skin to healthy adults aged 18 to 55.

  Recruiting Phase 1 Oneness Biotech Co., Ltd. · Melbourne · NCT07417124

• Linoleic acid–rich oil versus blended oil for adults with insulin resistance

  This trial will test whether taking a linoleic acid–rich oil daily for 8 weeks improves insulin resistance in adults who already have insulin resistance.

  Recruiting Pontificia Universidad Catolica de Chile · Santiago, Santiago Metropolitan · NCT07287514

• Lowering blood pressure by adding stair climbing to brisk walking

  We will test whether adding short daily stair climbing to a brisk-walking program lowers systolic blood pressure in adults 35 and older who have high blood pressure, are overweight, and are not regularly active.

  Recruiting Karolinska Institutet · Stockholm and 3 other locations · NCT06952348

• Exploring how insomnia affects health and fitness

  This study looks at how insomnia affects health and fitness in different groups of people to see what impact it has on things like body composition and exercise ability.

  Recruiting Universidad Autonoma de Baja California · Ensenada, Estado de Baja California · NCT06869486

• Improving coronary blood flow in women with HIV and diabetes or chronic kidney disease

  This study will test whether referring women with HIV and diabetes or chronic kidney disease to a specialist so they can be considered for SGLT2 inhibitor medicine, compared with health education alone, improves blood flow in their hearts.

  Recruiting Phase 2 Massachusetts General Hospital · Boston, Massachusetts · NCT06843902

• Comparing conventional and tailored limb lengths in gastric bypass surgery

  This study is testing whether customizing the lengths of certain parts of gastric bypass surgery can help people lose more weight and improve their health compared to standard lengths.

  Recruiting GEM Hospital & Research Center · Coimbatore, Tamil Nadu · NCT06756789

• Examining drug interactions in older adults living with HIV

  This study looks at how different medications interact in older adults with HIV to see if we can improve their treatment plans.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna · NCT06717581

• First-episode psychosis brain metabolism and antipsychotic effects

  This study tests how 4 to 6 weeks of antipsychotic medication affect brain metabolism in young adults with a first episode of psychosis.

  Recruiting Université de Sherbrooke · Sherbrooke, Quebec · NCT06651112

• Investigating the safety and effectiveness of porcine pancreatic cells in patients with Type 1 diabetes

  This study is testing if using pig pancreas cells can help adults with tough-to-manage Type 1 diabetes feel better and avoid dangerous low blood sugar episodes.

  Recruiting Phase 1/2 Otsuka Pharmaceutical Factory, Inc. · Chicago, Illinois · NCT06575426

• Evaluating HST101 for lowering cholesterol in Chinese patients

  This study is testing if a new drug called HST101 can lower cholesterol levels in Chinese patients who have high cholesterol and are at risk for heart disease.

  Recruiting at 17 sites Phase 3 Hasten Biopharmaceutical Co., Ltd. · Beijing, Beijing Municipality and 17 other locations · NCT06568471

• Collection of biospecimens for cardiovascular and metabolic research

  This study is collecting blood, urine, stool, and heart tissue samples from people with and without heart and metabolic diseases to help researchers learn more about these conditions and improve treatments.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT06560424

• Effects of Lipids on Health in Night Shift Workers

  This study is testing how certain fats in the body affect heart health and blood sugar in people who work night shifts, while also trying a new eating schedule to see if it helps.

  Recruiting Colorado State University · Fort Collins, Colorado · NCT06550115

• Effects of Haskap Berries on Gut Health and Metabolism

  This study tests whether drinking smoothies made with Haskap berries can improve gut health and metabolism in people over eight weeks.

  Recruiting Montana State University · Bozeman, Montana · NCT06546020

• Examining biomarkers in osteoarthritic thumb joints

  This study is testing how certain markers in the thumb joints of people with osteoarthritis relate to their overall health and comparing them to knee joints, while also looking at grip strength and pain before and after surgery.

  Recruiting Region Skane · Malmö, Skåne County and 1 other locations · NCT06370312

• Monitoring glucose levels in pregnant women to improve gestational diabetes diagnosis

  This study is testing if using a continuous glucose monitor can help better diagnose gestational diabetes in pregnant women of Chinese and Indian descent.

  Recruiting KK Women's and Children's Hospital · Singapore, Singapore · NCT06357728

• Evaluating Large Neutral Amino Acids for Treating Phenylketonuria

  This study is testing if Large Neutral Amino Acids can be a better treatment for adults with Phenylketonuria than the usual diet that limits phenylalanine.

  Recruiting Copenhagen University Hospital, Rigshospitalet · Copenhagen and 1 other locations · NCT06337864

• Using whole-body MRI to identify significant health issues in the general population

  This study is testing if whole-body MRI scans can help find serious health problems like cancer and heart issues in people aged 18 and older.

  Recruiting Hercules · Watertown, Massachusetts · NCT06212479

• Endoscopic sleeve gastroplasty for people with obesity and MASH

  This study will test whether endoscopic sleeve gastroplasty plus lifestyle changes helps adults with obesity and MASH lose weight and improve liver health compared with lifestyle changes alone.

  Recruiting at 2 sites Brigham and Women's Hospital · Boston, Massachusetts and 1 other locations · NCT06138821

• Understanding Pyrimidine and Purine Metabolism Disorders

  This study is trying to learn more about pyrimidine and purine metabolism disorders by comparing affected people with their healthy family members to see what factors might influence their condition.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT06092346

• Evaluating recovery of continence and sexual function after prostate cancer surgery

  This study is testing a new support program to see if it helps men recover better from prostate cancer surgery, focusing on their bladder control, sexual function, and overall health.

  Recruiting University of Alberta · Edmonton, Alberta · NCT06072911

• Using the 'Support' online training and peer program for adults with type 1 diabetes

  This project will test whether adults with type 1 diabetes who get access to the online 'Support' training and peer platform through their diabetes clinic manage their diabetes better than those who use the platform on their own.

  Recruiting at 4 sites McGill University · Montreal, Quebec and 3 other locations · NCT06069583

• Understanding how metabolism and inflammation affect diabetes in teens

  This study is trying to see how body weight, lifestyle, and diet affect inflammation and metabolism in teens to better understand diabetes risk.

  Recruiting University of Michigan · Ann Arbor, Michigan · NCT06007404

• Improving blood sugar and reducing inflammation through diet changes.

  This study is testing whether a gluten-free diet and probiotics can help improve blood sugar levels and reduce inflammation in healthy people, including those with and without diabetes.

  Recruiting Göteborg University · Gothenburg and 1 other locations · NCT05894746

• Comparing the effects of bariatric arterial embolization and gastric bypass on obesity and diabetes

  This study is testing whether a new procedure called bariatric arterial embolization can help people with obesity and Type 2 diabetes just as well as the traditional gastric bypass surgery.

  Recruiting Universidade Nova de Lisboa · Lisbon · NCT05859022

• Comparing three short running HIIT schedules for cardiometabolic health in young adults with obesity

  This project will try three different short-term running HIIT schedules versus no training to see which best improves cardiometabolic markers in 18–25-year-olds with obesity.

  Recruiting Syracuse University · Syracuse, New York · NCT05838950

• Effects of weight loss with and without exercise on metabolic health

  This study is testing whether losing weight with exercise helps improve metabolic health more than just losing weight through dieting alone for people with obesity.

  Recruiting University of Michigan · Ann Arbor, Michigan · NCT05806801

• Endoscopic Antral Myotomy for Weight Loss

  This study is testing a new weight loss procedure called Pylorus Sparing Antral Myotomy to see if it helps people with obesity lose weight safely and effectively on its own.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT05711758

• Biorepository for cardiovascular and metabolic disease research

  This study is collecting blood, urine, and stool samples from people with heart and metabolic diseases to help researchers better understand these conditions and improve care.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT05628948

• Examining facial features in boys with creatine transporter deficiency

  This study looks at photos of boys and young men with creatine transporter deficiency to see if they share certain facial features that could help doctors diagnose the condition more accurately.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT05600946

• Network for studying rare and atypical diabetes

  This study is trying to find and understand rare types of diabetes by testing people and families who haven't been diagnosed yet, using blood tests and genetic screening to learn more about these conditions.

  Recruiting at 13 sites University of South Florida · Aurora, Colorado and 12 other locations · NCT05544266

• Cognitive-behavioral therapy and exercise training for teenage girls at risk for type 2 diabetes

  This study is testing if cognitive-behavioral therapy, exercise training, or both can help teenage girls at risk for type 2 diabetes improve their health and reduce stress and depression.

  Recruiting at 2 sites Colorado State University · Aurora, Colorado and 1 other locations · NCT05543083

• Treating insomnia to improve heart and metabolic health in older adults with PTSD

  This study is testing if treating insomnia with therapy can help older adults with PTSD improve their heart health and overall well-being.

  Recruiting University of California, Los Angeles · North Hills, California · NCT05516277

• Effects of metabolic health patterns on breast cancer outcomes in women

  This study is testing whether improving metabolic health through diet and activity changes can help women with breast cancer feel better and reduce their heart disease risk during and after chemotherapy.

  Recruiting at 2 sites University of Alberta · Edmonton, Alberta and 1 other locations · NCT05432856

• Metabolic and infectious diseases in La Réunion

  Researchers are testing how common metabolic and infectious diseases are in La Réunion and what factors like microbiota and genetics might influence them, by examining 2,000 adults over two years.

  Recruiting Institut National de la Santé Et de la Recherche Médicale, France · La Réunion, Saint-Pierre · NCT05400824

• Understanding the molecular causes and risks of kidney and related diseases

  This study is trying to understand the genetic and environmental factors that cause kidney diseases and their complications to help improve treatment and care for people at risk or already diagnosed.

  Recruiting University Hospital, Toulouse · Toulouse · NCT05318196

• Cohort study on Dampness Syndrome in Traditional Chinese Medicine

  This study is looking at how Dampness Syndrome in Traditional Chinese Medicine might be linked to chronic diseases like diabetes, cancer, and dementia in people aged 35 to 75 over five years.

  Recruiting Guangzhou University of Traditional Chinese Medicine · Guangzhou, Guangdong · NCT05315895

• Investigating the link between obesity and Alzheimer's disease

  This study is trying to see how being overweight or obese affects the risk of developing Alzheimer's disease in healthy adults aged 40-60.

  Recruiting Washington University School of Medicine · St Louis, Missouri · NCT05077579

• Investigating the link between androgens and metabolic risk in women

  This study is trying to see how hormone levels affect the risk of metabolic diseases in women with polycystic ovary syndrome (PCOS).

  Recruiting Royal College of Surgeons, Ireland · Dublin · NCT04912648

• Understanding how environmental factors affect human health

  This study looks at how things like pollution and diet affect our health, especially inflammation and metabolic diseases, by collecting samples and health information from participants.

  Recruiting National Institutes of Health Clinical Center (CC) · Research Triangle Park, North Carolina · NCT04888923

• Long-term observation of ultra-rare inherited neurological diseases.

  This study is looking to learn more about very rare inherited neurological diseases by tracking and collecting information from patients over a long time to see how these conditions change and affect their lives.

  Recruiting Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta · Milan, Milano · NCT04880356

• Effects of exercise on fat tissue in obese individuals

  This study tests how exercise affects fat tissue in people with obesity to see if it can help improve their metabolism and manage weight better.

  Recruiting University of Michigan · Ann Arbor, Michigan · NCT04812314

• Haploidentical stem cell transplantation for treating immune and metabolic disorders in children

  This study is testing a new way to use stem cells from family members to treat children with immune and metabolic disorders to see if it helps them feel better.

  Recruiting Phase 2 Johns Hopkins All Children's Hospital · St. Petersburg, Florida · NCT04414046

• Identifying mortality risk in patients with metabolic diseases

  This study is trying to find out what factors can help predict the risk of death in people with metabolic diseases by looking at their health data and biological samples.

  Recruiting at 3 sites University Hospital, Lille · Boulogne-sur-Mer and 2 other locations · NCT04194372

• Improving metabolic health in Black individuals using natriuretic peptide augmentation

  This study is testing if a medication can boost certain hormones to improve metabolic health in Black individuals at risk for diabetes.

  Recruiting Phase 2 University of Alabama at Birmingham · Birmingham, Alabama · NCT04055428

• Real-time continuous glucose monitoring for young adults at risk of DKA

  This project will try a Dexcom G6 real-time continuous glucose monitor to see if it helps 18-25-year-olds with insulin-treated diabetes who have poor blood sugar control or recent hospital admissions for high blood sugar.

  Recruiting Imperial College London · London · NCT04039763

• Impact of Metabolic Abnormalities and Lifestyle on Heart Failure

  This study is trying to see how things like diet, exercise, and metabolic health affect the long-term outcomes for people with heart failure.

  Recruiting Ruijin Hospital · Shanghai, Shanghai Municipality · NCT03951311

• Effects of Bariatric Surgery and Lifestyle Changes on Fat and Liver Health

  This study is testing how bariatric surgery and lifestyle changes affect fat and liver health in people with obesity and related metabolic issues.

  Recruiting Chinese University of Hong Kong · Hong Kong, Shatin · NCT03875625

• Understanding Propionic Acidemia and Its Effects

  This study is trying to learn more about propionic acidemia by looking at how it affects people with the condition and their families over time.

  Recruiting at 2 sites National Institutes of Health Clinical Center (CC) · Bethesda, Maryland and 1 other locations · NCT02890342

• Evaluation of children with endocrine and metabolic conditions

  This study is testing how endocrine and metabolic disorders affect children from 3 months to 18 years old by looking at their medical history and physical exams, and it may involve family members in genetic testing to help with diagnosis.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT02769975

• Characterizing patients with rare cardiovascular diseases

  This study is trying to learn more about rare heart diseases by testing people who have these conditions, their family members, and healthy volunteers to see how these diseases develop and what causes them.

  Recruiting at 2 sites National Institutes of Health Clinical Center (CC) · Washington D.C., District of Columbia and 2 other locations · NCT01143454

NIH-funded research (newest 40 of 48)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Dysfunctional fat tissue and its link to fatty liver and diabetes

  Researchers are studying how problems in fat tissue contribute to fatty liver disease and type 2 diabetes in adults.

  NIH research University of Kansas Medical Center · Kansas City, United States · NIH-11593113

• Role of the body's natural cannabis-like system in diabetes progression and heart risk

  This grant studies how the body's endocannabinoid system affects the progression from obesity to diabetes and the associated risk for cardiovascular disease in adults.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-11451041

• Exploring vagal gut-brain signals to treat obesity

  Researchers are studying how the vagus nerve communicates about eating to see if targeting gut-brain signals can help treat obesity.

  NIH research Monell Chemical Senses Center · Philadelphia, United States · NIH-11421471

• Early-life sodium loss and brain signals that shape long-term heart and metabolism health

  This project studies how losing sodium in early life can set the brain’s pressure and salt-checking system to influence heart and metabolic health later on.

  NIH research Medical College of Wisconsin · Milwaukee, United States · NIH-11420078

• Role of gut bacteria–driven Th17 cells in metabolic health

  A study in mice explores how specific gut bacteria help protect against obesity- and diabetes-like changes by shaping a type of immune cell in the gut.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11408423

• Genetics of chronotype and its links to metabolic disease

  Researchers are studying how a person’s natural daily rhythm and sleep timing influence the risk for adult-onset diabetes and related metabolic problems.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11391256

• Targeting arginine metabolism to treat fatty liver and insulin resistance

  It explores whether changing how the liver handles the amino acid arginine can reduce fatty liver and improve insulin resistance for people with NAFLD/NASH.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11381030

• Understanding how fats in the cell’s antenna (primary cilia) affect metabolic diseases like adult-onset diabetes

  This project studies how the lipid makeup of primary cilia in human cells influences GPCR signals that control hunger, insulin release, and fat cell formation, with a focus on adults with adult-onset diabetes.

  NIH research Stanford University · Stanford, United States · NIH-11373060

• Choline transporters and cellular nutrition in health and disease

  This grant investigates a high-affinity choline transporter in human cells to understand how choline gets into cells and how this affects health and metabolic diseases.

  NIH research Rockefeller University · New York, United States · NIH-11372266

• A nanodrug to improve gut and liver health in adults with type 2 diabetes

  A new orally delivered nanodrug called PRORA aims to restore healthy gut signaling to help people with type 2 diabetes and related liver and cancer risks.

  NIH research University of California at Davis · Davis, United States · NIH-11367805

• Enteroendocrine cell reprogramming in metabolic disease

  A study exploring how gut hormone–producing cells can be reprogrammed to improve long-term weight management in obesity.

  NIH research Tufts University Boston · Boston, United States · NIH-11365664

• Early life stress and how it shapes metabolic risk from birth

  New research will study how stress before birth sets the stage for obesity and metabolic problems, by looking at cells from newborns and tracking fat development in infants.

  NIH research University of California-Irvine · Irvine, United States · NIH-11347838

• Understanding how ACAD10 and ACAD11 affect fat metabolism and diabetes

  Aimed at uncovering how two enzymes, ACAD10 and ACAD11, help break down fats in the body and how this relates to adult-onset diabetes.

  NIH research Washington University · Saint Louis, United States · NIH-11330373

• How ASO drugs behave and may cause side effects in people using a human liver-kidney model

  This grant tests how FDA-approved antisense oligonucleotides travel through and affect human liver and kidney tissues using a combined microphysiological system.

  NIH research Javelin Biotech · Billerica, UNITED STATES · NIH-11316401

• Why people with diabetes get less benefit from aerobic exercise

  This project explores why people with diabetes often gain less cardiorespiratory fitness from aerobic exercise and looks for ways to help their muscles adapt better.

  NIH research Virginia Polytechnic Inst and St Univ · Blacksburg, United States · NIH-11297253

• How chemical marks on RNA in fat tissue affect metabolism and obesity

  Researchers are looking at whether reversible chemical marks on RNA in fat cells change how fat grows and signals, with the aim of helping people with obesity and metabolic problems.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11292850

• How metabolism helps protect organs during sepsis

  Researchers are looking at whether natural metabolic molecules can neutralize harmful hydrogen peroxide and help people with sepsis protect their organs.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11260610

• Everyday chemical exposures and diabetes risk in middle and later life

  Researchers will measure many environmental chemicals and blood markers to find links to type 2 diabetes and metabolic syndrome in middle-aged and older adults.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11252283

• How SH2B1 brain circuits control body weight and metabolism

  This project looks at whether brain cells that use the protein SH2B1 help control appetite, weight, and blood sugar in people with or at risk for type 2 diabetes.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11238986

• Gut bacteria-driven Th17 immune cells and metabolic health

  This research looks at whether friendly gut bacteria that trigger Th17 immune cells can protect people with obesity or metabolic syndrome by lowering gut inflammation and reducing fat absorption.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11234944

• Copper balance in liver metabolism and fatty liver disease

  Poor copper balance in the liver may drive worsening fatty liver disease, and restoring copper could help liver health in people at risk.

  NIH research University of Nebraska Lincoln · Lincoln, United States · NIH-11210162

• Understanding how choline moves in the body for health and metabolic conditions

  This project aims to discover how a vital nutrient called choline enters human cells, which is important for overall health and conditions like metabolic disease.

  NIH research Rockefeller University · New York, United States · NIH-11182655

• Understanding how cell parts called primary cilia contribute to human metabolic conditions like adult-onset diabetes

  This research explores how tiny cell structures called primary cilia, and the fats within them, influence signals that are important for conditions like adult-onset diabetes.

  NIH research Stanford University · Stanford, United States · NIH-11171429

• A new nanodrug for treating metabolic diseases

  This study is testing a new oral medication designed to help people with type 2 diabetes and reduce the risk of liver and colorectal cancers by improving gut health, and it has shown promising results in mice.

  NIH research University of California at Davis · Davis, United States · NIH-11171208

• Targeting vagus nerve signals that control appetite to help treat obesity

  This project tests whether changing gut-to-brain nerve signals can reduce overeating and help people with diet-related obesity prefer healthier foods.

  NIH research Monell Chemical Senses Center · Philadelphia, United States · NIH-11141467

• Understanding why people with metabolic diseases struggle to adapt to aerobic exercise

  This study is looking into why people with metabolic diseases like diabetes might not get the full benefits from aerobic exercise, focusing on how high blood sugar levels can affect muscle responses, and it aims to find ways to help these individuals improve their exercise results for better health.

  NIH research Virginia Polytechnic Inst and St Univ · Blacksburg, United States · NIH-11133512

• Understanding how obesity affects COVID-19 and how COVID-19 impacts metabolism

  This project explores how having obesity changes the way your body responds to COVID-19, and how the virus itself might affect your metabolism.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11117098

• Understanding Copper's Role in Insulin Resistance and Liver Disease

  This project explores how copper and certain proteins might contribute to insulin resistance and a common liver condition called non-alcoholic fatty liver disease (NAFLD).

  NIH research Boston Children's Hospital · Boston, United States · NIH-11115592

• Understanding how certain enzymes affect fat breakdown and metabolic diseases

  This study is looking at how certain enzymes help break down a type of fatty acid that could be important for people with obesity and type 2 diabetes, to see how they might affect energy production in the body.

  NIH research Washington University · Saint Louis, United States · NIH-11094748

• How fat tissue changes can lead to diabetes and other diseases

  This study is looking at how changes in fat tissue can lead to problems like type 2 diabetes and heart issues, and it hopes to find new treatments that could help improve health for people dealing with obesity-related conditions.

  NIH research Boston University Medical Campus · Boston, United States · NIH-11071318

• Identifying genes that affect metabolic diseases and insulin resistance

  This study is looking at how our genes might affect insulin resistance, which can lead to type 2 diabetes, and it's especially focused on helping veterans and people of African descent by finding new treatment options.

  NIH research VA San Diego Healthcare System · San Diego, United States · NIH-11063124

• Investigating the role of a protein in liver disease and metabolic disorders

  This study is looking at how a protein called SUN1 might affect liver health in people with metabolic dysfunction-associated steatotic liver disease (MASLD), and we're inviting patients to help by sharing genetic samples to see how different versions of this protein could play a role in this condition.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11057704

• Understanding how psychological and biological factors predict obesity treatment success

  This study is looking at how your personality and certain biological markers can help predict how well you can lose weight and stick to a healthy lifestyle if you have obesity, with the goal of finding better ways to support you in your weight loss journey.

  NIH research Yale University · New Haven, United States · NIH-11051909

• How unhealthy fat tissue affects liver disease and diabetes

  This study is looking at how unhealthy fat in our bodies can lead to fatty liver disease and type 2 diabetes, and it aims to find ways to help people improve their metabolic health by understanding how fat works in our bodies.

  NIH research University of Kansas Medical Center · Kansas City, United States · NIH-11044229

• Investigating how RNA modifications in fat cells affect metabolic diseases

  This study is looking at how certain changes in RNA in fat tissue might affect metabolism and contribute to obesity and diabetes, using specially modified mice to help find new ways to treat these conditions that could benefit people like you.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11043323

• Investigating how specific brain circuits influence obesity and metabolic diseases

  This study is looking at a protein called SH2B1 in the brain that helps control weight and metabolism, and it aims to find out how it affects appetite and energy use, which could lead to better treatments for obesity and type 2 diabetes.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11022271

• Investigating how environmental chemicals affect diabetes risk in older adults

  This study is looking at how everyday chemicals in our environment might affect the risk of developing type-2 diabetes and metabolic syndrome in people as they get older, and it’s for anyone interested in understanding how these factors could impact their health.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11015832

• Understanding liver disease mechanisms in growth-restricted fetuses

  This study looks at how being small in the womb can affect liver growth and increase the chances of liver problems later in life, using fetal sheep to understand how low oxygen levels can harm the liver, which could help find ways to protect babies born with this condition.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-10995902

• How metabolic diseases affect circadian rhythms and dietary therapy

  This study is looking at how our body’s internal clock affects metabolic diseases, especially in people with Alzheimer's and Parkinson's, to see if fixing sleep patterns and diet can help improve their symptoms.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-10993167

• Understanding how Foxc2 affects metabolic diseases

  This study is looking at a protein called Foxc2 to see how it affects the lymphatic system, which helps with fluid balance and immune health, and it could help find new ways to treat heart and weight-related issues like obesity and atherosclerosis.

  NIH research Boston Children's Hospital · Boston, United States · NIH-10990522

Related topics

Quick answers

How many Metabolic Disease clinical trials are recruiting right now?

51, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 17 countries. The most sites are in United States (26 trials), Canada (4 trials), Sweden (3 trials), France (3 trials), China (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Phase 1: 2, Phase 1/2: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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