Obesity's role in blood pressure and insulin resistance in PCOS
Role of obesity in blood pressure regulation and insulin resistance in Polycystic Ovary Syndrome
This work explores how excess body fat and male hormones affect blood pressure and insulin resistance in women with PCOS.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Mississippi Med Ctr NIH-funded |
| Lab location | 1 site (Jackson, United States) |
| Project ID | NIH-11235104 on NIH RePORTER |
What this research studies
From a patient's point of view, the team is looking at how high androgen levels, body fat, and hormone systems inside fat tissue interact to raise blood pressure and cause insulin resistance in PCOS. They will study blood and fat tissue from women with PCOS and use lab models, including 3-D cell approaches, to examine the classical and nonclassical renin-angiotensin systems in adipose tissue and adiponectin levels. The project compares lean and obese women with PCOS to separate obesity-dependent from obesity-independent effects of hyperandrogenemia. The goal is to pinpoint fat-tissue pathways that could be targeted to improve metabolic and blood pressure problems in PCOS.
Who could benefit from this research
Good fit: Women of reproductive age diagnosed with PCOS—including both lean and obese individuals and those with insulin resistance or elevated blood pressure—would be the ideal candidates.
Not a fit: Men, people without PCOS, or those whose blood pressure or insulin problems come from unrelated conditions are unlikely to benefit directly.
Why it matters
Potential benefit: If successful, this work could identify new treatment targets in fat tissue to lower blood pressure and improve insulin sensitivity for women with PCOS.
How similar studies have performed: Previous studies have linked adipose RAS and adiponectin to blood pressure and insulin sensitivity, but applying these findings specifically to develop PCOS treatments is relatively new.
Where this research is happening
Jackson, United States
- University of Mississippi Med Ctr — Jackson, United States (Active)
Researchers
- Principal investigator: Yanes Cardozo, Licy Lorena — University of Mississippi Med Ctr
- Study coordinator: Yanes Cardozo, Licy Lorena
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.