Obesity's role in blood pressure and insulin resistance in PCOS
Official title: Role of obesity in blood pressure regulation and insulin resistance in Polycystic Ovary Syndrome
Funded at University of Mississippi Med Ctr · NIH-11235104 · Data updated 2026-11-12
This work explores how excess body fat and male hormones affect blood pressure and insulin resistance in women with PCOS.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Mississippi Med Ctr NIH-funded |
| Lab location | 1 site (Jackson, United States) |
| Project start | December 1, 2023 |
| Project end | November 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $638,534 |
| NIH project number | 5R01HL171494-03 |
| Project ID | NIH-11235104 on NIH RePORTER |
Who could benefit from this research
✓Could help
Women of reproductive age diagnosed with PCOS—including both lean and obese individuals and those with insulin resistance or elevated blood pressure—would be the ideal candidates.
✕Less likely to help
Men, people without PCOS, or those whose blood pressure or insulin problems come from unrelated conditions are unlikely to benefit directly.
What this research studies
From a patient's point of view, the team is looking at how high androgen levels, body fat, and hormone systems inside fat tissue interact to raise blood pressure and cause insulin resistance in PCOS. They will study blood and fat tissue from women with PCOS and use lab models, including 3-D cell approaches, to examine the classical and nonclassical renin-angiotensin systems in adipose tissue and adiponectin levels. The project compares lean and obese women with PCOS to separate obesity-dependent from obesity-independent effects of hyperandrogenemia. The goal is to pinpoint fat-tissue pathways that could be targeted to improve metabolic and blood pressure problems in PCOS.
Why it matters
Potential benefit: If successful, this work could identify new treatment targets in fat tissue to lower blood pressure and improve insulin sensitivity for women with PCOS.
How similar studies have gone: Previous studies have linked adipose RAS and adiponectin to blood pressure and insulin sensitivity, but applying these findings specifically to develop PCOS treatments is relatively new.
Where this research is happening
-
University of Mississippi Med Ctr
Jackson, United States Active
Researchers
- Principal investigator: Yanes Cardozo, Licy Lorena — University of Mississippi Med Ctr
- Study coordinator: Yanes Cardozo, Licy Lorena
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How obesity affects blood pressure and insulin resistance in women with Polycystic Ovary Syndrome
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.