Investigating how certain immune cells affect insulin resistance in adolescents
The role of circulating meta-inflammatory monocytes in adolescent insulin resistance
This study is looking at how certain immune cells in the body might affect insulin resistance in teenagers, especially when they eat unhealthy foods, to help identify those who may be at risk for weight-related health issues in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11092894 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of specific immune cells, known as meta-inflammatory monocytes, in the development of insulin resistance among adolescents. By examining how these cells respond to unhealthy diets, the study aims to identify adolescents who are at higher risk for metabolic diseases. The approach includes both clinical assessments and animal models to explore the mechanisms behind these immune responses and their impact on insulin sensitivity. The goal is to develop markers that can help predict which adolescents may face future health challenges related to obesity and insulin resistance.
Who could benefit from this research
Good fit: Ideal candidates for participation include adolescents aged 12 to 18 who are experiencing obesity or related metabolic issues.
Not a fit: Patients who are not adolescents or those without obesity-related health concerns may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to early identification of adolescents at risk for metabolic diseases, allowing for timely interventions.
How similar studies have performed: Previous research has shown promising results in understanding immune responses related to obesity, suggesting that this approach could yield valuable insights.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Singer, Kanakadurga — University of Michigan at Ann Arbor
- Study coordinator: Singer, Kanakadurga
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.