Hepatic insulin resistance linking type 2 diabetes and fatty liver disease

Who could benefit from this research

What this research studies

If this research succeeds, it could clarify the liver’s role in linking high blood sugar with fatty liver disease and inflammation. The team uses genetic mouse models to turn off specific liver signals and studies how these changes affect fat storage and liver inflammation. They also analyze human data to see if these liver-derived factors are elevated in people with fatty liver disease and how they relate to disease progression. The findings could guide future strategies to prevent or slow NASH by targeting liver pathways.

Why it matters

Where this research is happening

• Boston Children's Hospital
  Boston, United States Active

Researchers

• Principal investigator: White, Morris F. — Boston Children's Hospital
• Study coordinator: White, Morris F.

Related research

Other NIH-funded projects on the same topics.

• Understanding the connection between type 2 diabetes and fatty liver disease

  This project explores how insulin resistance in the liver links type 2 diabetes with non-alcoholic fatty liver disease, which can progress to a more serious condition called NASH.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11184358

• Investigating how a gene variant affects diabetes and liver disease in African Americans

  This study is looking at how a certain gene variant affects the risk of developing type 2 diabetes and fatty liver disease, especially in African American communities, and it invites patients to share their genetic samples or health information to help uncover how this variant influences insulin and sugar processing in

  NIH research University of Minnesota · Minneapolis, United States · NIH-11085899

• Understanding how insulin resistance affects type 2 diabetes and fatty liver disease

  This study is looking at how type 2 diabetes can affect liver health, especially when it comes to fatty liver disease, by testing a sugary diet on mice to find out what happens and how we might help people with these conditions in the future.

  NIH research Boston Children's Hospital · Boston, United States · NIH-10980982

• Lipid signals that control acetyl-CoA and fat metabolism in NAFLD

  A study exploring how membrane lipids influence acetyl-CoA metabolism to understand and potentially treat nonalcoholic fatty liver disease (NAFLD).

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-11591466

• Long-term study of NAFLD progression and gut bacteria in diverse groups

  We’re following people over time to see how the gut microbiome and diet relate to fatty liver disease progression in diverse racial/ethnic groups.

  NIH research University of Hawaii at Manoa · Honolulu, United States · NIH-11453729

• Profiling immune cells to find early inflammation clues in kids with obesity and insulin resistance

  This project looks at how immune cells in children with obesity may show early inflammatory changes linked to insulin resistance.

  NIH research University of Tennessee Health Sci Ctr · Memphis, United States · NIH-11452629

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.