Condition

Non-Alcoholic Fatty Liver Disease clinical trials and research

• 52Clinical trials
• 31Countries

Newest Non-Alcoholic Fatty Liver Disease clinical trials

All recruiting trials (52)

• Additive Physical Activity for Hypothyroidism in Older Women with Glaucoma and Fatty Liver

  We’re testing whether adding a treadmill-based exercise program to standard thyroid treatment helps improve health in older women who have subclinical hypothyroidism, glaucoma, and fatty liver.

  Recruiting Cairo University · Dokki, Giza Governorate · NCT07599241

• Lowering insulin to reduce liver fat production

  This study will try a short course of diazoxide to lower insulin and see if it reduces the liver's creation of new fat in adults with obesity, insulin resistance, and MASLD.

  Recruiting Phase 1 Columbia University · New York, New York · NCT07403604

• Efimosfermin alfa for adults with liver impairment

  This trial will test a single dose of efimosfermin alfa in adults with cirrhosis-related hepatic impairment from steatotic liver disease, with and without significant alcohol use, to measure drug levels and safety.

  Recruiting at 5 sites Phase 1 GlaxoSmithKline · Rialto, California and 4 other locations · NCT07358546

• Efimosfermin alfa for adults with biopsy-confirmed F2 or F3 MASH

  This trial will test whether efimosfermin alfa can resolve steatohepatitis and improve liver-related outcomes in adults with biopsy-confirmed F2 or F3 MASH.

  Recruiting at 91 sites Phase 3 GlaxoSmithKline · Chandler, Arizona and 90 other locations · NCT07221227

• Efimosfermin alfa injections for adults with F2–F3 MASH

  This study tests whether efimosfermin alfa injections are safe and tolerable for adults (18–75) with known or suspected metabolic dysfunction-associated steatohepatitis (MASH) and F2–F3 fibrosis.

  Recruiting at 66 sites Phase 3 GlaxoSmithKline · Arcadia, California and 65 other locations · NCT07221188

• Mediterranean diet with or without aerobic exercise for women with familial Mediterranean fever and fatty liver

  This trial will test whether adding regular aerobic exercise to a Mediterranean diet helps women with familial Mediterranean fever who have non-alcoholic fatty liver disease.

  Recruiting Cairo University · Dokki, Giza Governorate · NCT07130318

• Cardiovascular health in children and young adults with chronic conditions

  This project will see if children and young adults (ages 6-25) with chronic health conditions show early signs of aging in large and small blood vessels using noninvasive imaging and clinical tests.

  Recruiting Semmelweis University · Budapest and 2 other locations · NCT07086989

• Evaluating efimosfermin for patients with compensated cirrhosis and metabolic dysfunction

  This study is testing if a new treatment called efimosfermin can help people with compensated cirrhosis and metabolic dysfunction feel better and improve their liver health.

  Recruiting at 30 sites Phase 2 GlaxoSmithKline · Chandler, Arizona and 29 other locations · NCT06920043

• Evaluating Carbocisteine for Nonalcoholic Fatty Liver Disease

  This study is testing if Carbocisteine can help adults with Nonalcoholic Fatty Liver Disease improve their liver health when combined with lifestyle changes like diet and exercise.

  Recruiting Phase 2 Tanta University · Tanta · NCT06863376

• Blood markers to detect liver scarring in fatty liver disease

  This will test whether blood markers can detect liver scarring in adults with NAFLD or NASH who are having or recently had a liver biopsy.

  Recruiting at 2 sites Roche Diagnostics GmbH · Copenhagen and 1 other locations · NCT06819917

• Comparing two exercise methods for treating fatty liver disease

  This study is testing which exercise method, continuous treadmill workouts or interval training, helps people with Non-Alcoholic Fatty Liver Disease lower their liver enzyme levels better while following a low-calorie diet.

  Recruiting Cairo University · Giza · NCT06803108

• Assessing liver fat changes in cancer patients undergoing chemotherapy

  This study is testing a new scanning method to see how chemotherapy affects liver fat in cancer patients before and after treatment.

  Recruiting Yunnan Cancer Hospital · Kunming, Yunnan · NCT06735118

• Tai Chi's effects on fatty liver disease in older adults

  This study is testing if practicing Tai Chi can help older adults with fatty liver disease improve their liver health and overall metabolism compared to regular exercise or no exercise at all.

  Recruiting Fujian Provincial Hospital · Fuzhou, Fujian · NCT06717828

• Evaluating criteria for reversing liver fibrosis in patients with NASH

  This study is trying to find better ways to see if liver damage can improve in people with NASH and fatty liver disease by looking at both medical data and simpler tests.

  Recruiting Beijing Municipal Administration of Hospitals · Beijing, Beijing Municipality · NCT06707129

• Effects of TOTUM-448 on liver fat and cardiometabolic health in people with MASLD

  This study is testing if a new dietary supplement called TOTUM-448 can help reduce liver fat and improve heart and metabolic health in people with Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD).

  Recruiting Valbiotis · Québec, Quebec · NCT06704321

• Evaluating the role of macrophages in obesity and metabolic function

  This study is testing how a specific protein affects fat cells in people with obesity compared to those who are lean, to better understand how obesity impacts health.

  Recruiting University of Missouri-Columbia · Columbia, Missouri · NCT06571474

• Identifying liver disease-specific gut microbiomes

  This study is trying to find out if certain gut bacteria are linked to chronic liver diseases in adults, including autoimmune hepatitis and primary biliary cholangitis, by analyzing blood and stool samples from patients and their household members.

  Recruiting Chungnam National University Hospital · Daejeon, Jung-gu · NCT06519162

• Improving liver health through metabolic surgery or medication

  This study is testing whether metabolic surgery or medication can improve liver health in people with liver disease and obesity.

  Recruiting at 2 sites Phase 4 The Cleveland Clinic · Phoenix, Arizona and 21 other locations · NCT06374875

• Using SGLT2 inhibitors to treat fatty liver disease in obese adolescents

  This study is testing if a medication called empagliflozin can help obese teenagers with fatty liver disease improve their liver health and overall well-being.

  Recruiting Phase 2 Ann & Robert H Lurie Children's Hospital of Chicago · Chicago, Illinois · NCT06355310

• Investigating insulin resistance using alpelisib in adults

  This study is testing if a drug called alpelisib can help us understand how insulin works in healthy adults compared to those at risk for type 2 diabetes.

  Recruiting Phase 1 Columbia University · New York, New York · NCT06354088

• Investigating immune and metabolic factors in early cardiovascular disease

  This study is testing if using digital wearables and AI-driven lifestyle changes can help people with early cardiovascular disease improve their heart health.

  Recruiting National University Hospital, Singapore · Singapore · NCT06211868

• Liver fat in children with celiac disease

  This study will try to see if children with celiac disease have fatty liver and how their liver tests and markers change with a gluten-free diet.

  Recruiting at 2 sites University of Palermo · Palermo, Palermo and 1 other locations · NCT06206616

• Endoscopic sleeve gastroplasty for people with obesity and MASH

  This study will test whether endoscopic sleeve gastroplasty plus lifestyle changes helps adults with obesity and MASH lose weight and improve liver health compared with lifestyle changes alone.

  Recruiting at 2 sites Brigham and Women's Hospital · Boston, Massachusetts and 1 other locations · NCT06138821

• Effects of soy milk on liver health in children with fatty liver disease

  This study is testing if drinking soy milk every day can help improve liver health in children with fatty liver disease compared to regular cow's milk.

  Recruiting Phase 2 Children's Hospital Medical Center, Cincinnati · Cincinnati, Ohio · NCT06133101

• Timed-Restricted Eating for Improving Metabolic Health

  This study is testing whether changing when people with obesity and insulin resistance eat can improve their metabolic health, liver fat, brain function, inflammation, and sleep quality.

  Recruiting Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam, North Holland · NCT06061042

• Understanding health improvements after mini gastric bypass surgery

  This study looks at how mini gastric bypass surgery can improve health issues related to obesity, like diabetes and sleep apnea, by tracking changes in body weight and other health markers after the surgery.

  Recruiting All India Institute of Medical Sciences, Bhubaneswar · Bhubaneswar, Odisha · NCT06015620

• Investigating liver disease risk in individuals with low birth weight

  This study is trying to see if people who were born with low birth weight are more likely to develop liver disease later in life compared to those who were born with normal weight.

  Recruiting Steno Diabetes Center Copenhagen · Herlev · NCT05890365

• Improving early diagnosis of liver cancer in high-risk patients in China

  This study is testing if regular check-ups for liver cancer can help catch the disease earlier in people at high risk due to conditions like chronic hepatitis or cirrhosis in China.

  Recruiting Ruijin Hospital · Shanghai, Shanghai Municipality · NCT05870969

• Investigating risk factors for liver inflammation and fibrosis in patients with chronic hepatitis B and non-alcoholic fatty liver disease

  This study is trying to find out what factors can increase the risk of liver inflammation and scarring in people with chronic hepatitis B and non-alcoholic fatty liver disease.

  Recruiting The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School · Nanjing · NCT05766449

• Using endoscopic ultrasound to assess liver stiffness in patients with fatty liver disease

  This study is testing if a special ultrasound can help find liver damage in people with fatty liver disease who are overweight, comparing it to other methods to see which works best.

  Recruiting at 2 sites Brigham and Women's Hospital · Boston, Massachusetts and 1 other locations · NCT05728697

• Understanding liver disease linked to alcohol and metabolic syndrome

  This study is trying to find out what causes liver cancer in people with alcohol-related liver disease and fatty liver disease by looking at their health, diet, and immune system over several years.

  Recruiting Institut National de la Santé Et de la Recherche Médicale, France · Nice · NCT05623150

• Preventing liver and heart disease through lifestyle changes

  This study is testing a lifestyle program to see if it can help people with gallstone disease and fatty liver disease prevent heart and liver problems by improving their diet and exercise habits.

  Recruiting Pontificia Universidad Catolica de Chile · Molina, Maule Region · NCT05618626

• Community-based cohort study on Non-Alcoholic Fatty Liver Disease

  This study looks at people with Non-Alcoholic Fatty Liver Disease to see how their health changes over time and to create a better way to understand their risk for serious health issues.

  Recruiting Beijing Friendship Hospital · Beijing · NCT05546086

• Effect of a fibre supplement on children with fatty liver disease

  This study is testing whether a fiber supplement can help children aged 8-17 with fatty liver disease improve their liver health over six months.

  Recruiting Phase 2 McMaster University · Hamilton, Ontario · NCT05480696

• Collecting data to predict cancer risk in at-risk populations

  This study is trying to collect samples and health information from people at higher risk of cancer to see if they can find signs that help predict cancer early on.

  Recruiting Dana-Farber Cancer Institute · Boston, Massachusetts · NCT05463796

• Impact of Meal Timing on Liver Fat in Patients with Non-Alcoholic Fatty Liver Disease

  This study is testing if eating within an 8-hour window along with a healthy diet and exercise can help reduce liver fat in people with non-alcoholic fatty liver disease.

  Recruiting Weill Medical College of Cornell University · New York, New York · NCT05332613

• Measuring liver metabolism in patients with diabetes and fatty liver

  This study is testing if a medication called pioglitazone can improve liver metabolism in people with type 2 diabetes and fatty liver disease over 16 weeks.

  Recruiting at 2 sites Phase 4 The University of Texas Health Science Center at San Antonio · San Antonio, Texas and 1 other locations · NCT05305287

• Understanding metabolic differences in patients with and without diabetes after a heart attack

  This study looks at how heart attacks affect people with and without diabetes to see if there are differences that can help improve treatment and care.

  Recruiting German Diabetes Center · Düsseldorf, North Rhine-Westphalia · NCT05046483

• Intermittent fasting to treat fatty liver disease in non-obese adults

  This study is testing if intermittent fasting can help non-obese adults with fatty liver disease improve their liver health and overall well-being.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT04899102

• Biobank and registry for non-alcoholic fatty liver disease

  This study is collecting liver tissue, blood, and urine samples from people with non-alcoholic fatty liver disease and those at risk to help find better treatments and understand the disease better.

  Recruiting AdventHealth Translational Research Institute · Orlando, Florida · NCT04807868

• Creating biological models to study liver diseases and tumors

  This study is trying to create new models to better understand liver diseases and tumors so that we can find better treatments for people suffering from these conditions.

  Recruiting Institut National de la Santé Et de la Recherche Médicale, France · Strasbourg · NCT04690972

• Improving early diagnosis of liver disease using integrated diagnostics

  This study is trying to improve how quickly and accurately liver disease is diagnosed by combining different tests and information from around 750 patients who are at risk or have abnormal liver blood tests.

  Recruiting Manchester University NHS Foundation Trust · Manchester, Greater Manchester · NCT04666402

• Assessing the prevalence of Non-Alcoholic Fatty Liver Disease in adults

  This study is trying to find out how common Non-Alcoholic Fatty Liver Disease is among adults in Olmsted County, Minnesota, to help improve early diagnosis and treatment options.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT04365855

• Registry for children with Non-Alcoholic Fatty Liver Disease in Europe

  This study is creating a large registry to help doctors learn more about Non-Alcoholic Fatty Liver Disease in children and improve future treatments.

  Recruiting at 2 sites Cambridge University Hospitals NHS Foundation Trust · Maastricht and 2 other locations · NCT04190849

• Investigating immune and metabolic features in non-alcoholic fatty liver disease

  This study is trying to learn more about the immune and metabolic features of non-alcoholic fatty liver disease by collecting samples from patients at different stages of the disease and comparing them to healthy individuals.

  Recruiting Queen Mary University of London · London, Greater London · NCT04141592

• Understanding liver response to glucose and the effects of semaglutide in fatty liver disease

  This study is testing how the liver of people with non-alcoholic fatty liver disease responds to food and whether the medication semaglutide can help improve liver health.

  Recruiting Phase 2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT03884075

• Effects of Bariatric Surgery and Lifestyle Changes on Fat and Liver Health

  This study is testing how bariatric surgery and lifestyle changes affect fat and liver health in people with obesity and related metabolic issues.

  Recruiting Chinese University of Hong Kong · Hong Kong, Shatin · NCT03875625

• Using cold exposure to activate brown fat and reduce liver fat

  This study tests if exposing overweight and obese people with fatty liver disease to cold can help activate their brown fat and reduce fat in their liver.

  Recruiting Medical University of Vienna · Vienna · NCT03811236

• NAFLD: Tracking Fibrosis and Steatosis Changes Over 10 Years in Biopsy-Proven Patients

  This observational study follows adults with biopsy-proven nonalcoholic fatty liver disease for 10 years to see how fibrosis and fat buildup change over time.

  Recruiting Beijing Friendship Hospital · Beijing, Beijing Municipality · NCT03635541

• Examining the impact of fatty liver disease in bariatric patients

  This study is trying to see how non-alcoholic fatty liver disease affects health outcomes in people with obesity who are having bariatric surgery compared to those who aren't.

  Recruiting Esbjerg Hospital - University Hospital of Southern Denmark · Esbjerg · NCT03535142

• Understanding Nonalcoholic Steatohepatitis in Chinese Children

  This study looks at liver disease in Chinese children to see how it differs from adults and understand its effects on their health.

  Recruiting Humanity and Health Research Centre · Beijing · NCT03190538

• Observational study on patients with non-alcoholic fatty liver disease

  This study is looking at liver tissue from people with non-alcoholic fatty liver disease to see how certain body signals relate to weight gain and insulin resistance over time.

  Recruiting University of Zurich · Zurich, Canton of Zurich · NCT00575133

Related topics

Quick answers

How many Non-Alcoholic Fatty Liver Disease clinical trials are recruiting right now?

52, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 31 countries. The most sites are in United States (19 trials), China (8 trials), United Kingdom (4 trials), Egypt (4 trials), Canada (4 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 6, Phase 1: 3, Phase 4: 2, Phase 3: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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