Condition

Cognitive Decline clinical trials and research

• 74Clinical trials
• 274NIH research projects
• 1New in 30 days
• 20Countries

Newest Cognitive Decline clinical trials

All recruiting trials (74)

• China HEAD: a large community study on healthy aging and dementia

  This study tests whether collecting health, imaging, and biospecimen data from adults in China can help predict who will develop Alzheimer’s disease and related dementias.

  Recruiting at 30 sites Fudan University · Beijing and 29 other locations · NCT07912710

• Can citicoline help prevent cognitive decline after delirium in older adults with hip fracture?

  This study tests whether taking citicoline for 6 months after discharge helps prevent cognitive decline in adults 65 and older who had delirium during hospitalization for hip fracture.

  Recruiting Phase 2 University of Milano Bicocca · Monza, Monza E Brianza · NCT07804498

• See if cognitive impairment is common in older adults admitted for non-neurological rehab

  This study tests how often cognitive impairment appears in patients aged 45 and older who are in non-neurological rehab units after hospitalization.

  Recruiting at 3 sites Fondazione Don Carlo Gnocchi ETS · Florence, FI and 2 other locations · NCT07731334

• Effects of a Multidomain Community Program on Thinking and Quality of Life for Older Adults

  This study tests whether a multidomain, community-based program can improve cognitive function and quality of life for adults aged 60 and up who are active participants at a center in Istanbul, Turkey.

  Recruiting Istanbul Medipol University Hospital · Istanbul, Bagcılar · NCT07610109

• Accelerated rTMS for Cognitive Function in adults with mild to moderate cognitive impairment

  This study tests whether a short course of accelerated rTMS with the EXOMIND device can improve thinking skills in adults ages 50–90 with mild cognitive impairment or mild dementia.

  Recruiting San Francisco Neurology and Sleep Center · San Francisco, California · NCT07547319

• Long-term walnut intake and brain function in abdominally obese adults

  This trial tests whether eating walnuts for 24 weeks improves brain blood flow and insulin sensitivity, and whether it boosts thinking and appetite control in adults with abdominal obesity.

  Recruiting Maastricht University Medical Center · Maastricht, Limburg · NCT07422220

• Integrated tracking of Alzheimer's risk using biological, psychological, and caregiver data

  We will test whether combining blood markers, brain imaging, cognitive testing, and caregiver-reported information can better identify early Alzheimer's stages in people aged 50 and older who have a primary caregiver.

  Recruiting Istituti Clinici Scientifici Maugeri SpA · Montescano, Pavia, Italy · NCT07399418

• Broccoli sprout extract to improve thinking and memory

  This will test whether taking broccoli sprout extract daily for 12 weeks improves thinking and memory in adults 55–85 with mild cognitive impairment.

  Recruiting Pusan National University Yangsan Hospital · Yangsan · NCT07334366

• Technology-assisted block training to boost thinking, hand dexterity, and grip strength in older adults

  This program will test whether technology-assisted block-building exercises help thinking skills, hand dexterity, and grip strength in community-dwelling adults aged 65 and older.

  Recruiting National Taipei University of Nursing and Health Sciences · Yilan, Taiwan · NCT07315724

• Feasibility of a Smartphone App to Support Mental Well-Being for Older Adults and Caregivers

  This pilot test checks whether the utmbHealthyBrain app can be used in community settings by adults 50+ and their caregivers to support mood and social connection over six weeks.

  Recruiting The University of Texas Medical Branch, Galveston · Galveston, Texas · NCT07313540

• Cognitive screening and multidomain care to slow memory and thinking decline in older adults with type 2 diabetes

  This study will test whether regular cognitive screening plus a two-year program of medication optimization, adjusted HbA1c targets, vascular risk management, lifestyle changes, and social support can slow cognitive decline in people aged 65 and older with type 2 diabetes.

  Recruiting at 3 sites Steno Diabetes Center Copenhagen · Copenhagen and 2 other locations · NCT07250789

• Immersive 360° VR plus chair aerobics to improve thinking in older adults with mild cognitive impairment

  We test whether adding immersive 360° VR videos to chair-based aerobic exercise helps older adults with mild cognitive impairment improve memory, attention, and thinking speed.

  Recruiting Foundation University Islamabad · Islamabad · NCT07242495

• Gut-derived flavonoid compounds to support thinking and memory

  This trial will test whether a polyphenol supplement that boosts gut-produced flavonoid metabolites can help slow cognitive decline in people aged 50 and older who are at increased risk for Alzheimer's.

  Recruiting University of Ulster · Coleraine · NCT07226674

• Sabroxy® for lowering insulin resistance and improving memory in adults with mild cognitive impairment

  This 8-week, double-blind, placebo-controlled test will see if taking Sabroxy® once daily lowers insulin resistance and improves thinking and memory in adults aged 40–80 with mild cognitive impairment and elevated fasting glucose or HOMA-IR.

  Recruiting SF Research Institute, Inc. · San Francisco, California · NCT07220694

• AI-powered fitness wearables and apps to boost activity in older adults living alone with cognitive decline

  This study tests whether an AI-driven fitness app and wearable program can help older adults living alone with cognitive decline be more physically active.

  Recruiting The University of Tennessee, Knoxville · Knoxville, Tennessee and 1 other locations · NCT07207993

• Video games versus ball-tossing to improve hand–eye coordination in older adults with mild cognitive impairment

  This project will test whether playing video games or doing ball-tossing exercises can improve hand–eye coordination in people aged 60 and older with mild cognitive impairment.

  Recruiting Foundation University Islamabad · Islamabad · NCT07182396

• Plant-based diets for healthy aging

  This project will test whether vegetarian and plant-based diets help middle-aged and older Tzu Chi volunteers maintain physical function and cognitive health as they age.

  Recruiting National Health Research Institutes, Taiwan · Dalin, Chiayi · NCT07151365

• How chronic non-specific low back pain affects thinking and the brain in older adults

  We will see if chronic non-specific low back pain is linked to poorer executive skills (like inhibition, switching, and working memory) and brain changes in people aged 60–85.

  Recruiting The Hong Kong Polytechnic University · Hong Kong · NCT07134699

• Goals-based exercise program for Black adults aged 45–65 to address cognitive decline

  This program will try a goals-based exercise plan to help Black adults aged 45–65 exercise more and see if that slows cognitive decline.

  Recruiting at 2 sites University of Colorado, Boulder · Aurora, Colorado and 1 other locations · NCT07127965

• Personalized program to prevent frailty and cognitive decline

  This 12-week program will try a mobile app combined with weekly group aerobic/resistance exercise and cognitive activities to help adults aged 60–85 with chronic diseases prevent frailty and cognitive decline.

  Recruiting National University of Singapore · Singapore · NCT07081282

• Phospholipid-rich dairy extract for mild memory problems

  This will test whether taking a daily phospholipid-rich dairy milk extract for 12 weeks helps adults aged 55–85 with mild cognitive impairment think and remember better and whether it is safe.

  Recruiting Pusan National University Yangsan Hospital · Yangsan · NCT07011680

• Using brain stimulation to improve memory and motivation in older adults

  This study is testing if a type of brain stimulation can help improve memory and motivation in older adults, including those showing early signs of Alzheimer's disease.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT06956300

• Improving DHA delivery in older adults at risk for dementia

  This study is testing whether two different types of DHA supplements can improve brain health in older adults who are showing early signs of memory problems.

  Recruiting University of Cincinnati · Cincinnati, Ohio · NCT06933095

• Making cognitive screening easy for primary care providers

  This project will test an automated Spanish‑language risk assessment and brief iPad cognitive screen to help primary care teams find early memory and thinking problems in people aged 60 and older.

  Recruiting at 3 sites University of Texas at Austin · Austin, Texas and 2 other locations · NCT06928298

• Evaluating Lion's Mane Mushroom Effects on Cognitive Health

  This study is testing whether taking Lion's Mane mushroom can help adults aged 40-75 who are worried about their memory and thinking skills feel better in areas like focus, mood, and sleep compared to a placebo.

  Recruiting M2 Ingredients · Los Angeles, California · NCT06870136

• Lifestyle intervention for older adults at risk of dementia

  This study is testing a personalized lifestyle program to see if it can help older adults at risk of dementia improve their brain health over a year.

  Recruiting Maastricht University Medical Center · Amsterdam and 1 other locations · NCT06832761

• Using brain stimulation and digital training to improve cognitive function in older adults

  This study is testing whether a combination of brain stimulation and digital training can help improve thinking skills in older adults with Mild Cognitive Impairment and Alzheimer's Disease.

  Recruiting Universidade Federal do Rio de Janeiro · Rio de Janeiro, Rio de Janeiro · NCT06733714

• Exploring the link between blood pressure and cognitive decline after stroke

  This study looks at how blood pressure levels might affect thinking and memory problems in people who have had a stroke.

  Recruiting First Affiliated Hospital of Chongqing Medical University · Chongqing, Chongqing Municipality · NCT06730711

• Memantine plus structured exercise to protect thinking and memory during breast cancer chemotherapy

  This will test whether memantine combined with a supervised exercise program, memantine alone, or a placebo can prevent or reduce thinking and memory problems in people receiving chemotherapy for stage I–III breast cancer.

  Recruiting Phase 2 UNC Lineberger Comprehensive Cancer Center · Chapel Hill, North Carolina · NCT06727773

• Investigating brain activation in stroke patients using virtual reality tasks

  This study is testing how virtual reality tasks can help us understand brain activity in stroke patients compared to healthy people, to see if it can aid in their cognitive recovery.

  Recruiting First Affiliated Hospital of Chongqing Medical University · Chongqing, Chongqing Municipality · NCT06703320

• Identifying biomarkers for cognitive impairment after stroke using fNIRS

  This study is trying to find brain signals that can help us understand cognitive problems after a stroke by comparing stroke patients with healthy people while they do thinking tasks.

  Recruiting First Affiliated Hospital of Chongqing Medical University · Chongqing, Chongqing Municipality · NCT06703307

• Improving sleep quality to enhance memory in older adults with mild cognitive impairment

  This study is testing whether using special sounds during sleep can help older adults with mild memory problems sleep better and improve their memory over time.

  Recruiting University of Bern · Bern · NCT06669546

• Using internet therapy to reduce depression and cognitive decline in older ICU survivors

  This study is testing if an online therapy program can help older adults who have been in the ICU feel less depressed and think better.

  Recruiting at 2 sites Indiana University · Indianapolis, Indiana and 1 other locations · NCT06627894

• Impact of cancer treatments on speech perception and quality of life

  This study is trying to see how different cancer treatments affect how well people can hear and understand speech in noisy places, as well as their overall quality of life related to hearing.

  Recruiting Turku University Hospital · Turku, Southwest Finland · NCT06551857

• Effects of polyphenols on cognitive decline in older adults

  This study is testing if a supplement made from polyphenols, which are found in Mediterranean foods, can help older adults at risk for Alzheimer's disease keep their brains healthy and slow down cognitive decline.

  Recruiting University of California, Los Angeles · Los Angeles, California · NCT06507254

• Exploring the effects of sleep loss on aging and cognitive decline

  This study is testing how not getting enough sleep affects thinking and aging in healthy people and those with memory problems or Alzheimer's disease.

  Recruiting First Affiliated Hospital of Zhejiang University · Hangzhou, Zhejiang · NCT06492109

• Effects of different anesthesia techniques on cognitive function in elderly hip fracture patients

  This study tests different anesthesia methods to see which one helps older patients with hip fractures keep their thinking skills sharp during and after surgery.

  Recruiting at 8 sites Second Affiliated Hospital of Wenzhou Medical University · Dongyang, Zhejiang and 12 other locations · NCT06452147

• Combining sleep promotion and cognitive training to improve brain function in older ICU survivors

  This study is testing if helping older adults who survived ICU treatment sleep better and do brain exercises can improve their thinking skills.

  Recruiting University of Washington · Seattle, Washington · NCT06411561

• Improving attention and wellbeing in older adults using digital tools

  This study is testing how different digital tools can help older adults improve their attention and overall wellbeing, especially for those at risk of dementia.

  Recruiting University of California, San Francisco · San Francisco, California · NCT06397469

• Investigating the causes and progression of neurocognitive disorders in Thailand

  This study is trying to understand how neurocognitive disorders like dementia progress in people in Thailand by looking at blood samples and cognitive tests from both healthy individuals and those with memory issues.

  Recruiting King Chulalongkorn Memorial Hospital · Pathum Wan, Bangkok · NCT06375213

• A new dual-task rehabilitation program for elderly cognitive decline

  This study is testing a new training program using virtual reality to see if it can help older adults with memory issues and mild cognitive impairment think better.

  Recruiting Istituto Auxologico Italiano · Milan, MI · NCT06290167

• Comparing light and deep anesthesia effects on postoperative delirium and cognition in older adults

  This study is testing if using lighter anesthesia during major surgery can help older adults avoid confusion and memory problems afterward.

  Recruiting at 2 sites Auckland City Hospital · Grafton, Auckland and 2 other locations · NCT06268080

• Impact of Dietary Fats on Cognitive Function

  This study tests whether eating walnuts or a dairy-free chocolate bar can improve thinking and memory in adults who feel their brain isn't working as well as it used to.

  Recruiting Ohio State University · Columbus, Ohio · NCT06223672

• Impact of MIND Diet and Aerobic Training on Cognition in Black Adults with High Blood Pressure

  This study is testing if following a special diet and doing aerobic exercise can help improve thinking skills and health in Black adults with high blood pressure.

  Recruiting Indiana University · Indianapolis, Indiana · NCT06152614

• Assessing sleep and circadian rhythms in older adults after major orthopedic surgery

  This study is testing how sleep patterns and certain biological markers in older adults after major orthopedic surgery can help us understand the risk of confusion and memory problems afterward.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT06052397

• Using lithium to prevent cognitive decline after brain radiotherapy in children

  This study is testing if taking lithium can help prevent memory and thinking problems in children who have survived brain tumors and received radiation therapy.

  Recruiting Phase 2 Region Stockholm · Solna, Stockholm County and 1 other locations · NCT06051240

• Examining cognitive and vascular functioning after traumatic brain injury

  This study is trying to see how brain injuries and heart health are connected to thinking problems in Service Members and Veterans.

  Recruiting Walter Reed National Military Medical Center · Bethesda, Maryland · NCT06034509

• Investigating the relationship between white matter hyperintensity shape and brain clearance in dementia

  This study is trying to see how the shape of certain brain changes in older adults with small vessel disease relates to their thinking skills and dementia.

  Recruiting Leiden University Medical Center · Leiden · NCT06010511

• Mindful walking program for older South Asian caregivers of individuals with cognitive disabilities

  This study is testing a 12-week mindful walking program to see if it can help older South Asian caregivers of people with cognitive disabilities feel less stressed and improve their mental sharpness.

  Recruiting at 8 sites University of Illinois Chicago · Bolingbrook, Illinois and 7 other locations · NCT06002919

• Investigating brain stimulation effects on memory in older adults with mild cognitive impairment

  This study is testing if a type of brain stimulation can help improve memory in older adults with mild cognitive impairment compared to those without memory issues.

  Recruiting University of Florida · Gainesville, Florida · NCT05998031

• Effects of treating sleep apnea on memory and Alzheimer's biomarkers in older adults

  This study is testing if treating sleep apnea can improve memory and brain health in older adults who don't have cognitive issues.

  Recruiting at 4 sites California Pacific Medical Center Research Institute · Tucson, Arizona and 3 other locations · NCT05988385

• mHealth intervention for improving sleep and cognition in low-income older adults

  This study is testing a mobile health program to see if it can help low-income older adults sleep better and think more clearly by encouraging physical activity and providing coaching.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT05935241

• Diet intervention to improve cognitive health in patients with carotid stenosis

  This study is testing whether following a special diet for six months can help improve brain health in people aged 40 and older with narrowed arteries in the neck.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT05922137

• Aerobic exercise program for older adults with mild cognitive impairment

  This study is testing if a 6-month aerobic exercise program can help older adults with mild cognitive impairment or early Alzheimer's improve their brain health and fitness.

  Recruiting Arizona State University · Phoenix, Arizona · NCT05877196

• Assessing cognitive decline using a new screening tool

  This study is testing a new tool to see if it can help people who notice their thinking skills declining, without any other brain problems, and whether cognitive training can help them improve.

  Recruiting Istituti Clinici Scientifici Maugeri SpA · Montescano, Pavia · NCT05815329

• Sleep impairment in people at risk for Alzheimer's disease

  This study will test whether sleep problems are linked with early Alzheimer's changes and cognitive decline in people at higher risk of the disease.

  Recruiting University Hospital, Montpellier · Montpellier, Hérault · NCT05649514

• Improving dementia treatment assessment methods

  This study is testing a new way to see if donepezil can help people with dementia feel better by looking at their thinking skills and daily activities, while also checking if certain markers in the body play a role in how well the treatment works.

  Recruiting The University of Texas Health Science Center at San Antonio · San Antonio, Texas · NCT05592678

• Mapping the anterior temporal lobe in patients with drug-resistant epilepsy

  This study tests a new way to map the brain in people with drug-resistant epilepsy to help doctors find the best spot to operate and reduce risks of side effects.

  Recruiting Central Hospital, Nancy, France · Nancy · NCT05339438

• Investigating brain health in youth at risk for type 2 diabetes

  This study is trying to see how being overweight or having blood sugar issues affects brain health in kids aged 12-17 who might be at risk for type 2 diabetes.

  Recruiting at 2 sites Washington University School of Medicine · St Louis, Missouri and 1 other locations · NCT05277558

• Using a polypill and lifestyle changes to prevent stroke and cognitive decline

  This study is testing whether a combination of a polypill and lifestyle changes can help people aged 50-75 in Brazil lower their risk of stroke and memory problems.

  Recruiting at 2 sites Phase 3 Hospital Moinhos de Vento · Porto Alegre, Rio Grande do Sul and 1 other locations · NCT05155137

• A program to reduce postoperative delirium in older surgical patients

  This study is testing a program to see if special education and care can help prevent confusion after surgery in older patients aged 60 and above.

  Recruiting Sunnybrook Health Sciences Centre · Toronto, Ontario · NCT05114876

• Reducing blood pressure to prevent cognitive decline in older adults

  This study is testing if better blood pressure management can help older adults with high blood pressure avoid memory problems and dementia.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT05106036

• Short mild low-oxygen sessions to support brain blood-vessel health in older adults

  We will test whether brief, controlled sessions of mild low-oxygen exposure, alone or combined with rehabilitative exercise, can improve brain blood-vessel function in inactive people aged 60 to 80.

  Recruiting University Hospital, Grenoble · La Tronche, Auvergne-Rhône-Alpes · NCT05048680

• Examining brain changes in colorectal cancer patients undergoing chemotherapy

  This study is trying to see how chemotherapy affects thinking and memory in people with colorectal cancer.

  Recruiting Parkview Health · Fort Wayne, Indiana · NCT05014399

• Testing cognitive decline in people at risk for Alzheimer's disease

  This study is testing how well healthy people of different ages and backgrounds perform on brain tasks to help spot early signs of cognitive decline related to aging.

  Recruiting Neurobehavioral Systems, Inc. · Berkeley, California · NCT04800588

• Assessing cognitive outcomes after skull base meningioma surgery

  This study is testing how surgery for removing skull base meningiomas affects thinking and memory in patients over time.

  Recruiting Ohio State University · Columbus, Ohio · NCT04635657

• Identifying risks of heart failure and cognitive decline in people with type 2 diabetes

  This study is trying to find out which adults with type 2 diabetes might be at risk for heart failure and memory problems so that they can get early help.

  Recruiting University Hospital, Lille · Lille · NCT04583800

• GnRH therapy to improve cognition in individuals with Down syndrome

  This study is testing if a new hormone treatment can help improve thinking skills and smell in adults with Down syndrome who are at risk for early Alzheimer's disease.

  Recruiting Phase 2/3 Centre Hospitalier Universitaire Vaudois · Lausanne, Canton of Vaud · NCT04390646

• Effects of melatonin on brain health and cognition in older adults

  This study is testing if taking 5mg of melatonin can improve brain health and thinking skills in older adults, especially those with mild cognitive impairment, over nine months.

  Recruiting University of Iowa · Iowa City, Iowa · NCT03954899

• Exploring biomarkers related to aging and cognitive decline

  This study is testing if new brain scans and memory tests can help find early signs of Alzheimer's disease in healthy older adults aged 60 to 85.

  Recruiting Phase 3 University of California, Irvine · Irvine, California · NCT03860857

• Combining 40Hz light therapy with cognitive training for Alzheimer's treatment

  This study is testing whether using a special iPad app that combines 40Hz light therapy with brain exercises can help improve thinking and daily life for people with Alzheimer's disease.

  Recruiting Alzheimer's Light LLC · Miami, Florida · NCT03657745

• Evaluating cognitive decline in older breast cancer patients

  This study is trying to see how cancer treatment affects thinking and memory in older women with breast cancer and what other factors might play a role.

  Recruiting Georgetown University · Washington D.C., District of Columbia · NCT03451383

• Predicting Delirium Risk After Heart Surgery Using a New Cognitive Tool

  This study is testing a new app to see if it can help doctors predict which older patients are at risk of developing confusion after heart surgery.

  Recruiting University Hospital, Basel, Switzerland · Basel · NCT03360838

• Epigenetic risk factors for silent brain injury after TAVR in older adults

  This project will test whether blood epigenetic markers can predict new silent stroke-like brain lesions and later memory decline in people over 70 having TAVR.

  Recruiting University Hospital, Lille · Lille · NCT02972008

NIH-funded research (newest 40 of 274)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• How COVID-19 infection and genes may influence memory and dementia risk

  This study looks at how getting COVID-19 and a person’s genes together affect the chance of developing memory problems and Alzheimer’s disease later in life.

  NIH research University of Texas Hlth Science Center · San Antonio, United States · NIH-11617103

• NGF Metabolism as a biomarker for cognitive decline in familial Alzheimer's disease

  Researchers are studying whether patterns in nerve growth factor pathways in blood and CSF can signal early, preclinical stages of Alzheimer's in people with genetic risk.

  NIH research Boston University (Charles River Campus) · Boston, United States · NIH-11597025

• NGF metabolism as an early biomarker for cognitive decline in familial Alzheimer's disease

  This project tests whether NGF pathway proteins in blood and CSF can signal early, preclinical changes in people with familial Alzheimer’s disease.

  NIH research Boston University (Charles River Campus) · Boston, United States · NIH-11597016

• NGF Metabolic Dysfunction as a Marker of Cognitive Decline in Autosomal Dominant Alzheimer's Disease

  This project looks at nerve growth factor pathways in people with a genetic form of Alzheimer's to see if blood and spinal fluid markers can identify early brain changes before symptoms appear.

  NIH research Boston University (Charles River Campus) · Boston, United States · NIH-11591274

• Optimizing a closed-loop digital meditation to help cognitive aging and stress in older adults

  A mobile, personalized meditation program is being tested to help older adults maintain thinking skills and lower stress.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11536281

• Cash transfers in South Africa to reduce dementia risk in later life

  This project tests whether government cash transfers in rural South Africa help protect people’s thinking and memory as they age.

  NIH research Trustees of Indiana University · Bloomington, United States · NIH-11534517

• Remote monitoring of Alzheimer’s changes in adults with Down syndrome

  A study tests remote (at-home) ways to track Alzheimer’s-related thinking changes in adults with Down syndrome.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11532997

• Exercise and brain health in older adults with kidney disease

  A study to see if a structured exercise program can slow cognitive decline in older adults with chronic kidney disease who are at risk for dementia.

  NIH research Georgetown University · Washington, United States · NIH-11530743

• Timed bright-light therapy to improve sleep and slow memory decline in older adults

  Afternoon bright-light therapy guided by AI aims to strengthen sleep patterns and slow thinking problems in older adults with mild cognitive impairment.

  NIH research University of Colorado · Boulder, UNITED STATES · NIH-11470740

• Tumor Susceptibility Gene 101: a microglial therapy approach to protect memory in Alzheimer’s disease

  A Mayo Clinic team is studying a protein called TSG101 in brain immune cells to slow or prevent cognitive decline in Alzheimer’s disease.

  NIH research Mayo Clinic Jacksonville · Jacksonville, United States · NIH-11463429

• Understanding subtle cognitive changes in older adults at risk for Alzheimer's disease

  This grant investigates how small, early cognitive changes appear in older adults and how they relate to Alzheimer’s biology, with the goal of spotting risk earlier.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11463424

• Gut microbiome and brain health in Puerto Ricans with Alzheimer’s risk

  We’re studying how the gut microbiome may influence cognitive aging and Alzheimer’s risk in Puerto Ricans aged 21 and older.

  NIH research University of Massachusetts Lowell · Lowell, United States · NIH-11463268

• Impact of brain-derived exosomes on Alzheimer’s disease biomarkers in older adults

  This project looks at tiny particles shed by brain cells in blood to see if they reveal early signs of Alzheimer’s and cognitive decline in older people.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11463254

• Boosting brain immune proteins AXL and MERTK to slow Alzheimer's memory loss

  This work boosts two immune-related proteins in brain support cells to try to slow memory loss linked to Alzheimer's disease.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11457055

• How inflammation-linked metabolism affects memory loss in aging and Alzheimer's

  Looking at whether blocking an inflammatory signal outside the brain can fix immune-cell metabolism and help memory in older adults and people with Alzheimer's.

  NIH research Stanford University · Stanford, United States · NIH-11456950

• Dynamic cognitive health from everyday online surveys in dementia research

  A big study uses everyday online surveys to read how people’s thinking changes over time, with the goal of spotting early signs of dementia.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11450394

• Digital memory checks to catch Alzheimer's early using remote tests

  A study tests new at-home digital memory tests to detect and monitor early signs of Alzheimer’s disease in adults 21 and older, aiming to catch changes before dementia develops.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11448128

• Longitudinal multi-omics map of cognitive decline and dementia

  A long-term study at University of Washington uses blood and brain data over many years to identify biological markers linked to cognitive decline and Alzheimer’s dementia, with the goal of finding new treatment targets.

  NIH research University of Washington · Seattle, United States · NIH-11447242

• Understanding how high-risk plaque and reduced brain blood flow affect thinking and memory

  This project looks at how advanced carotid plaque and lower brain perfusion may contribute to vascular cognitive impairment and dementia, with a plan to identify patients who are at risk.

  NIH research University of Washington · Seattle, United States · NIH-11446620

• Risk factors for cognitive decline across the lifespan in twin families

  A long-term study using twins and their relatives to understand what tends to increase or protect against cognitive decline as people age.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11445624

• Cognitive decline in early Alzheimer’s: restoring a key brain chemical

  A study explores whether boosting a natural brain cofactor (BH4) can help people with early Alzheimer’s or mild cognitive impairment slow memory loss.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11445150

• Pilot Mindfulness Intervention for Chronic Pain and Early Cognitive Decline in Older Black Adults

  A small study tests a mindfulness-based program tailored for older Black adults with chronic pain and early cognitive decline to see if it’s feasible and possibly helpful.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11440208

• Neuroinflammation as a Target to Protect Thinking in Heart Failure Patients

  A small feasibility study will test whether a brain scan can show that a heart-failure treatment reduces brain inflammation and protects thinking skills in people with heart failure and cognitive concerns.

  NIH research State University New York Stony Brook · Stony Brook, United States · NIH-11439425

• Cerebellum changes in aging and cognitive decline

  Researchers are studying how aging affects the cerebellum and how these brain changes relate to moments of cognitive decline in people aged 65 and older.

  NIH research Texas A&m University · College Station, United States · NIH-11426236

• Biomarkers of Cognitive Decline in Normal Adults (BIOCARD Cohort)

  A long-running study follows people who started out cognitively healthy to identify early brain changes that may signal future Alzheimer’s disease.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11422400

• Smart driving tech to detect early cognitive changes in adults with Alzheimer’s and related dementias

  A new, unobtrusive system uses in-car sensors and AI to monitor driving and biometrics to spot early cognitive changes in people 21 and older who have or are at risk for Alzheimer’s disease and related dementias.

  NIH research Tf Health Corporation · Fountain Hills, United States · NIH-11418920

• Exercise adherence and goal-setting to boost activity in older Black adults

  A study tests a goal-setting and exercise-intensity plan designed to help Black adults 65+ stay physically active and support brain health.

  NIH research University of Colorado · Boulder, UNITED STATES · NIH-11418036

• Mitochondria and Thinking in Aging Brains: How Energy Rooms Affect Memory in Alzheimer’s

  This project looks at how mitochondrial energy in the aging brain relates to cognitive decline and Alzheimer’s disease in people and in people with mitochondrial DNA disorders.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11413806

• Peripheral immune signals and blood vessel health in aging and dementia

  This project looks at how platelet and neutrophil activity relate to brain changes and biomarkers of Alzheimer’s disease in older adults, especially those at higher cardiovascular risk.

  NIH research New York University School of Medicine · New York, United States · NIH-11413466

• Understanding cognitive decline and Alzheimer’s changes in people with long‑duration type 1 diabetes

  A long-term study in adults with type 1 diabetes investigates why some people experience memory and thinking difficulties and brain changes typical of Alzheimer's disease.

  NIH research Joslin Diabetes Center · Boston, United States · NIH-11411470

• How lifelong economic hardship might speed biological aging and affect thinking in midlife

  This project looks at whether limited resources across life speed up biological 'epigenetic' aging and lead to worse thinking and memory in adults during midlife.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11411039

• Novel small molecule boosters of brain connections to help memory in Alzheimer’s disease

  A small-molecule drug candidate called NQ-013 is being developed to boost synaptic communication and improve memory in models of Alzheimer’s disease.

  NIH research Encue INC. · Evanston, United States · NIH-11407657

• Sex differences in how cannabis affects memory and brain health in older adults

  This study looks at whether older men and women who regularly use cannabis experience different effects on memory and risk factors for Alzheimer's disease.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11404808

• How COVID-19 and genetics influence memory and dementia risk in older adults

  This project studies how getting COVID-19 interacts with people’s genetic makeup to affect the likelihood of cognitive decline and Alzheimer’s disease in older adults from diverse backgrounds.

  NIH research University of Texas Hlth Science Center · San Antonio, United States · NIH-11401787

• Predicting Early Dementia Risk from Health Records Using AI

  A plan to use big health records and smart computer methods to spot people who may be in the early stages of memory decline before dementia

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11399877

• Metacognitive Strategy Help for Parkinson’s-Related Thinking Difficulties

  Aimed at people with Parkinson’s disease who have thinking and memory challenges, this project tests a practical, everyday strategy approach to help with daily tasks and improve quality of life.

  NIH research Washington University · Saint Louis, United States · NIH-11399024

• Ultrafine Air Particles and Brain Health in Alzheimer’s Risk

  This project looks at whether tiny air particles can reach the brain and contribute to cognitive decline and Alzheimer’s-related dementia.

  NIH research University of California at Davis · Davis, United States · NIH-11398008

• Attenuating Depression with Internet CBT to Slow Cognitive Decline in Older ICU Survivors

  A new online cognitive behavioral therapy program is being tested to help older ICU survivors who are experiencing depressive symptoms and may be at risk for cognitive decline.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11397007

• Grit and memory protection in aging and early Alzheimer’s disease

  Aging adults at risk for Alzheimer’s disease may keep sharper thinking if they have grit, and this project explores how motivation and brain signals relate to memory in at-risk older adults.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11396474

• Mitigating Age-Related Memory Loss with a New Brain-penetrant Lipid Therapy

  A small, early-stage project tests a new brain-penetrant lipid therapy intended to boost brain regeneration and reduce age-related memory decline in conditions like Alzheimer’s disease and ADRD.

  NIH research Immunova, LLC · Gainesville, United States · NIH-11395066

Related topics

Quick answers

How many Cognitive Decline clinical trials are recruiting right now?

74, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 20 countries. The most sites are in United States (33 trials), China (7 trials), Italy (5 trials), France (5 trials), Netherlands (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Phase 3: 2, Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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