Investigating brain network changes in Type 2 Diabetes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the changes in the Papez circuit neural network activity and connectivity in patients with Type 2 Diabetes Mellitus (T2DM) using multimodal MRI and machine learning techniques. It will involve 200 T2DM patients and 200 healthy controls, who will undergo clinical assessments, biochemical measurements, and cognitive evaluations over a 6-year period with follow-ups every 36 months. The goal is to develop a predictive model for cognitive impairment associated with T2DM, facilitating early assessment and personalized treatment strategies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. T2DM patients met the diagnostic criteria for diabetes (WHO, 1999) with a duration of 3-20 years; The control group met the criteria of fasting blood glucose \< 6.1mmol/l and glycosylated hemoglobin \< 5.7%;
2. right-handed, aged 45-70 years, with ≥8 years of education;
3. no contraindications to MRI scanning such as electronic and metal device implantation;
4. The visual acuity or corrected visual acuity and binaural hearing can meet the needs of the evaluation, and can cooperate to complete the examination.
5. without a history of substance abuse or dependence, evaluation is not used during the period of calm sleeping pills and antidepressants, not long-term use of drugs to improve cognitive.

Exclusion Criteria:

1. patients with acute metabolic complications or a history of severe hypoglycemia;
2. severe heart, liver, lung, kidney and hematopoietic system diseases; Hyperthyroidism or hypothyroidism; Stroke, alzheimer's disease, epilepsy, Parkinson's disease and other neurological history; A history of mental illness such as depression, mania, or alcohol dependence; History of loss of consciousness due to neurological diseases or traumatic brain injury;
3. one month before the laboratory examination, with a record and surgical trauma infection;

Where it's running

• Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University
  Nanjing, Jiangsu, China Recruiting

Study contacts

• Study coordinator: Wenqing Xia, PHD
• Email: wen_qing_xia@126.com
• Phone: +8617749597285

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Alpelisib Challenge Test to measure insulin secretory capacity

  Researchers will test a new approach to measure how much insulin the body can produce in people at various weights and with or without insulin resistance, using alpelisib around a meal test.

  Recruiting Phase 1 Columbia University · New York, New York · NCT07778524

• Cognitive screening and multidomain care to slow memory and thinking decline in older adults with type 2 diabetes

  This study will test whether regular cognitive screening plus a two-year program of medication optimization, adjusted HbA1c targets, vascular risk management, lifestyle changes, and social support can slow cognitive decline in people aged 65 and older with type 2 diabetes.

  Recruiting at 3 sites Steno Diabetes Center Copenhagen · Copenhagen and 2 other locations · NCT07250789

• Understanding how metabolism and inflammation affect diabetes in teens

  This study is trying to see how body weight, lifestyle, and diet affect inflammation and metabolism in teens to better understand diabetes risk.

  Recruiting University of Michigan · Ann Arbor, Michigan · NCT06007404

• Acute Blood Flow Restriction Walking in Type 2 Diabetes

  This study tests whether adding blood flow restriction to treadmill walking affects immune cells in adults with type 2 diabetes.

  Recruiting University of British Columbia · Kelowna, British Columbia · NCT07928531

• Continuous Glucose Monitoring in Type 2 Diabetes Not on Insulin

  This study tests whether using a continuous glucose monitoring system helps people with type 2 diabetes who aren’t using insulin to improve blood sugar control and quality of life.

  Recruiting Medical University of Bialystok · Bialystok · NCT07919236

• Asprosin and miRNA Profiles in Young Women with Metabolic Syndrome

  This study tests whether certain blood biomarkers, including asprosin and six microRNAs, differ between young women with metabolic syndrome and healthy peers.

  Recruiting University of Applied Sciences in Nowy Targ · Nowy Targ, Lesser Poland Voivodeship · NCT07917364

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.