Measuring a biomarker in patients with chronic mesenteric ischemia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to compare plasma levels of Alpha glutathione S transferase (Alpha GST) in patients diagnosed with chronic mesenteric ischemia (CMI) and median arcuate ligament syndrome (MALS) against individuals with Morbus Crohn, gallstone disease, and healthy controls. The study will include patients scheduled for surgical treatment and will assess changes in Alpha GST levels pre- and post-treatment. Additionally, it will evaluate the health-related quality of life of participants. The goal is to identify a reliable biomarker for intestinal ischemia that could aid in diagnosis and treatment decisions.

Why it matters

Who can join: the full rules

Inclusion Criteria: Above 18 years and has given informed written consent for treatment and study participation

For the patient groups :

Group 1: Has CTA or ultrasound diagnosed MALS and is scheduled operative treatment.

Group 2: Has CTA or ultrasound diagnosed CMI and is scheduled operative or endovascular treatment.

For the control group:

Group 3- Has ultrasound based diagnosis of cholelithiasis and is scheduled for cholecystectomy.

Group 4- Has established Mb Crohn diagnosis and under gastric lab follow-up. Group 5- Young healthy blood donors of mean age 45 years and has excluded MALS or CMi with ultrasound.

Group 6- Healthy blood donors of mean age 70 years and has excluded MALS or CMi with ultrasound.

Exclusion Criteria: Age less than 18 years Has nor given written consent.

\-

Where it's running

• Department of vascular surgery, Oslo University Hospital
  Oslo, Oslo, Norway Recruiting

Study contacts

• Principal investigator: Syed Sajid Hussain Kazmi, MD, PhD — Department of vascular surgery, Oslo University Hospital
• Study coordinator: Syed Sajid Hussain Kazmi, MD, PhD
• Email: sshkazmi@gmail.com
• Phone: 4792468309

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Electrosurgical Patterns and Learning Curve in Laparoscopic Gallbladder Surgery

  This study observes how surgeon experience relates to patterns of electrosurgery use during elective laparoscopic gallbladder removal to see if experience affects intraoperative difficulty.

  Recruiting University Hospital of Split · Split, Split-Dalmatia County · NCT07888491

• Microencapsulated Propionate vs Butyrate for Crohn's Disease in Remission

  This study tests whether microencapsulated sodium propionate can favorably alter the gut microbiota and inflammation in adults with Crohn’s disease, compared with sodium butyrate.

  Recruiting University of Padova · Padova · NCT07883044

• Risankizumab for Refractory Perianal Fistulizing Crohn's Disease

  This study tests whether risankizumab can help people with Crohn’s disease who have draining perianal fistulas not responding to other treatments.

  Recruiting Phase 4 Hyogo Medical University · Nishinomiya and 3 other locations · NCT07872449

• Improvised retrieval bag vs direct gallbladder extraction in laparoscopic cholecystectomy

  This trial tests whether using an improvised retrieval bag to remove the gallbladder during laparoscopic cholecystectomy is as safe and effective as removing it directly without a bag in adults with gallbladder stones.

  Recruiting Rawal Institute of Health Sciences Islamabad · Islamabad, Federal · NCT07823803

• Intestinal ultrasound-guided management for inflammatory bowel disease

  This study tests if adding point-of-care intestinal ultrasound at every visit changes treatment decisions for adults with Crohn’s disease or ulcerative colitis undergoing disease assessment.

  Recruiting Mahidol University · Bangkok · NCT07775352

• Laser-based sizing of GI lesions during endoscopies

  This study tests whether the AccuMeasure laser tool gives more accurate and reliable lesion size measurements during colonoscopies for adults with colon polyps or Crohn’s disease than traditional endoscopic estimates.

  Recruiting Centre hospitalier de l'Université de Montréal (CHUM) · Montreal, Quebec · NCT07770425

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.