Evaluating bone health in adolescents with Crohn disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates bone marrow composition and bone mineral density in newly diagnosed adolescents with Crohn disease compared to healthy controls. Using advanced imaging techniques such as magnetic resonance imaging, dual-energy X-ray absorptiometry, and peripheral quantitative computed tomography, the study aims to identify abnormalities in bone marrow fat and its relationship with bone health. The research will also explore the underlying mechanisms affecting bone turnover and health in this population. A total of 46 adolescents with Crohn disease will be matched with 46 healthy peers based on age, puberty stage, and BMI percentile.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Crohn's Disease diagnosed within the past 3 months, or a healthy, matched control

Exclusion Criteria:

* Participants with chronic disease known to affect skeletal metabolism
* Participants on certain medications within the prior 3 months that are known to affect skeletal metabolism
* Participants who are pregnant
* Participants who have a history of: claustrophobia, internal body metal that is not compatible with MRI machine, or a known abnormality on or adjacent to the left knee

Where it's running

• Boston Children's Hospital
  Boston, Massachusetts, United States Recruiting

Study contacts

• Principal investigator: Rebecca Gordon, MD — Boston Children's Hospital
• Study coordinator: Rebecca Gordon, MD
• Email: rebecca.gordon@childrens.harvard.edu
• Phone: (617) 355-7476

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.