Evaluating bone health in adolescents with Crohn disease
Skeletal Health and Bone Marrow Composition in Newly Diagnosed Adolescents With Crohn Disease
This study is trying to see how Crohn disease affects bone health in teenagers by comparing their bone density and marrow fat to those of healthy teens.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 92 (estimated) |
| Ages | 13 Years to 20 Years |
| Sex | All |
| Sponsor | Massachusetts General Hospital Academic / other |
| Locations | 1 site (Boston, Massachusetts) |
| Trial ID | NCT04508088 on ClinicalTrials.gov |
What this trial studies
This observational study investigates bone marrow composition and bone mineral density in newly diagnosed adolescents with Crohn disease compared to healthy controls. Using advanced imaging techniques such as magnetic resonance imaging, dual-energy X-ray absorptiometry, and peripheral quantitative computed tomography, the study aims to identify abnormalities in bone marrow fat and its relationship with bone health. The research will also explore the underlying mechanisms affecting bone turnover and health in this population. A total of 46 adolescents with Crohn disease will be matched with 46 healthy peers based on age, puberty stage, and BMI percentile.
Who should consider this trial
Good fit: Ideal candidates include adolescents recently diagnosed with Crohn disease or healthy adolescents matched for comparison.
Not a fit: Patients with chronic diseases affecting bone health or those on certain medications may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of bone health in adolescents with Crohn disease.
How similar studies have performed: While studies have explored bone health in IBD, this specific focus on bone marrow composition in adolescents with Crohn disease is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Crohn's Disease diagnosed within the past 3 months, or a healthy, matched control Exclusion Criteria: * Participants with chronic disease known to affect skeletal metabolism * Participants on certain medications within the prior 3 months that are known to affect skeletal metabolism * Participants who are pregnant * Participants who have a history of: claustrophobia, internal body metal that is not compatible with MRI machine, or a known abnormality on or adjacent to the left knee
Where this trial is running
Boston, Massachusetts
- Boston Children's Hospital — Boston, Massachusetts, United States (Recruiting)
Study contacts
- Principal investigator: Rebecca Gordon, MD — Boston Children's Hospital
- Study coordinator: Rebecca Gordon, MD
- Email: rebecca.gordon@childrens.harvard.edu
- Phone: (617) 355-7476
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.