Online positive psychology program to improve mental health and quality of life in Crohn's disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults aged 18–75 with Crohn's disease and mild to moderate anxiety or depression (GAD-7 or PHQ-9 scores 5–14) will be enrolled and randomized to receive an online positive psychology intervention or routine care. The intervention is delivered via WeChat and mobile apps and uses structured exercises to increase positive emotions, thoughts, and behaviors. Eligible participants must be able to read, access the internet, and complete online sessions and follow-up assessments; those with psychiatric illness or current psychiatric medication use are excluded. Study outcomes focus on changes in mental health symptoms and quality of life over the follow-up period.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients diagnosed with Crohn's disease according to the 2018 diagnostic criteria established by the Inflammatory Bowel Disease Group of the Chinese Medical Association's Gastroenterology Branch;
* Patients aged between 18 and 75 years;
* Patients with a score of 5-14 on the GAD-7 (indicative of mild to moderate anxiety) or a score of 5-14 on the PHQ-9 (indicative of mild to moderate depression);
* Patients who understand and agree to comply with the study requirements and have signed informed consent;
* Patients who are able to read and access the internet, either independently or with assistance from a family member, and are capable of using WeChat and mobile applications;
* Patients who are able to complete all course trainings and/or follow-up procedures.

Exclusion Criteria:

* Individuals with a history or current diagnosis of psychiatric illness or cognitive impairment, or those currently taking psychiatric medications; Individuals working in the field of psychology, or those who have previously studied or are currently studying positive psychology;
* Individuals with concurrent other intestinal diseases or malignancies;
* Individuals with severe primary diseases of the cardiovascular, cerebrovascular, hepatic, or renal systems.

Withdrawal Criteria:

* Patients lost to follow-up due to withdrawal or other reasons during the intervention period;
* Patients who develop severe complications or experience significant changes in their condition that prevent them from continuing the study.

Where it's running

• The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou
  Hangzhou, Zhejiang, China Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.