Creating 3D models of the intestine from biopsy samples
Intestinal Organoids
This study is trying to create 3D models of the intestine from biopsy samples to help understand digestive diseases better and find new treatments.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 90 (estimated) |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Sponsor | Rennes University Hospital Academic / other |
| Locations | 1 site (Rennes) |
| Trial ID | NCT05294107 on ClinicalTrials.gov |
What this trial studies
This project focuses on generating a biocollection of 3D intestinal organoids derived from digestive biopsies, which will be characterized alongside associated health data. The organoids aim to replicate the functional complexity of the human intestine, providing a more accurate model for studying digestive diseases such as inflammatory bowel disease. By using these organoids, researchers hope to screen potential therapeutic molecules and better understand the cellular and molecular mechanisms involved in these conditions. The study involves collecting additional biopsies during routine endoscopy procedures.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 to 75 who are undergoing endoscopy and require digestive biopsy samples.
Not a fit: Patients who are under legal protection or those on anticoagulant treatments (except for low-dose aspirin) may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to more effective treatments for patients with inflammatory bowel diseases.
How similar studies have performed: Other studies utilizing organoids for understanding digestive diseases have shown promising results, indicating a potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Subjects aged 18 to 75 years * Subject undergoing endoscopy as part of the standard of care with the need to take digestive biopsy samples * Subject having signed a free and informed consent in writing Exclusion Criteria: * Subjects under legal protection (safeguard of justice, curatorship or guardianship) or deprived of liberty. * Anticoagulant treatment and anti-platelet treatment (except for aspirin 75 mg)
Where this trial is running
Rennes
- CHU de RENNES-Service des Maladies de l'Appareil Digestif — Rennes, France (Recruiting)
Study contacts
- Principal investigator: Guillaume BOUGUEN, Professor — Rennes University Hospital
- Study coordinator: Guillaume BOUGUEN, Professor
- Email: guillaume.bouguen@chu-rennes.fr
- Phone: 2 99 28 99 72
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.