Drug or treatment

Ustekinumab clinical trials

• 22Clinical trials
• 26Countries

Newest trials

All recruiting trials (22)

• Guselkumab after Ustekinumab in adults with moderate-to-severe psoriasis in routine care

  This study looks at how well guselkumab works for people with moderate-to-severe psoriasis after switching from ustekinumab in everyday clinical practice.

  Recruiting Janssen-Cilag Kft. · Budapest · NCT07746583

• Switching to ustekinumab for kids with Crohn's or ulcerative colitis who developed psoriasis after anti-TNF therapy

  This study tests whether switching to ustekinumab helps children with inflammatory bowel disease who developed psoriasis while on anti-TNF drugs.

  Recruiting Centre Hospitalier Universitaire de Nice · Nice, France · NCT07529236

• Guselkumab for adults with Crohn's disease after ustekinumab failure

  This study will try guselkumab for adults with moderate to severe Crohn's disease who did not respond to or could not tolerate ustekinumab to see if they reach remission after 52 weeks.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07487480

• Guselkumab vs Ustekinumab for stricturing Crohn's disease

  This study will follow adults with moderate-to-severe Crohn's disease and confirmed intestinal strictures to see if treatment with guselkumab or ustekinumab better controls obstructive symptoms and disease activity.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07444060

• Guselkumab for Chinese patients with Crohn's disease who stopped responding to ustekinumab

  This study tests whether guselkumab can help Chinese patients with active Crohn's disease who initially responded to ustekinumab but later lost response.

  Recruiting at 5 sites Phase 4 Xian-Janssen Pharmaceutical Ltd. · Guangzhou and 4 other locations · NCT07310095

• Reducing ustekinumab dosing for Crohn's disease and ulcerative colitis

  This will try giving ustekinumab less often—changing from every 4 or 8 weeks to every 8 or 12 weeks—to see if people with Crohn's disease or ulcerative colitis in deep remission can stay well.

  Recruiting Phase 4 McGill University Health Centre/Research Institute of the McGill University Health Centre · Montreal, Quebec · NCT07303686

• Switching to guselkumab for adults with active IBD after ustekinumab

  We will try guselkumab (Tremfya) in adults with active IBD whose symptoms didn't improve enough on ustekinumab.

  Recruiting at 12 sites TIDHI Innovation Inc. · Calgary, Alberta and 13 other locations · NCT07245394

• Ustekinumab for mucocutaneous Behçet's syndrome

  This study will see if a biosimilar of ustekinumab helps adults with mucocutaneous Behçet's syndrome who are refractory to or intolerant of standard treatments, compared with patients treated with apremilast.

  Recruiting at 2 sites Groupe français d'étude des Maladies Inflammatoires de loeil · Bordeaux and 10 other locations · NCT07244614

• Long-term safety of deucravacitinib versus ustekinumab for plaque psoriasis (PRAGMATYK)

  This study will test whether deucravacitinib or ustekinumab has better long-term safety for adults with moderate-to-severe plaque psoriasis who have cardiovascular risk factors.

  Recruiting at 323 sites Phase 3 Bristol-Myers Squibb · Birmingham, Alabama and 410 other locations · NCT07116967

• Switching adults with Crohn's disease from Stelara (ustekinumab) to the biosimilar Uzpruvo

  This will see if adults with stable Crohn's disease who switch from Stelara® to the biosimilar Uzpruvo® stay on the biosimilar and remain well over 12 months.

  Recruiting at 10 sites EG Labo · Amiens and 10 other locations · NCT07077681

• Observational study on patients switching to a biosimilar treatment for Crohn's disease and plaque psoriasis

  This study is testing if switching to a new biosimilar treatment for Crohn's disease and plaque psoriasis helps patients stay in remission and feel satisfied with their care.

  Recruiting Celltrion HealthCare France · Amiens · NCT06997055

• Combining Ustekinumab with Semi-Enteral Nutrition for Crohn's Disease Before Surgery

  This study is testing if combining a medication called Ustekinumab with a special diet can help adults with Crohn's Disease feel better and get healthier before surgery.

  Recruiting Sixth Affiliated Hospital, Sun Yat-sen University · Guangzhou, Guangdong · NCT06912815

• Ustekinumab for immune checkpoint inhibitor-related diarrhea and colitis in cancer patients

  This will test whether ustekinumab can control immune-related diarrhea and colitis in adults receiving immune checkpoint inhibitors for solid tumors.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT06807593

• Comparing target therapies for ulcerative colitis after anti-TNFα treatment

  This study is testing how well three different treatments work for adults with ulcerative colitis who haven't improved after their first anti-TNF-alpha therapy.

  Recruiting Humanitas Clinical and Research Center · Mialn, Italy · NCT06691061

• Comparing dual-target therapy with intensified Ustekinumab for Crohn's disease

  This study is testing if a new combination treatment of Ustekinumab and Upadacitinib can help people with Crohn's disease feel better compared to a higher dose of Ustekinumab alone.

  Recruiting Phase 4 Sixth Affiliated Hospital, Sun Yat-sen University · Guangzhou, Guangdong · NCT06520397

• Comparing two drugs and their combination for treating ulcerative colitis

  This study is testing if using a combination of two drugs, infliximab and ustekinumab, can help adults with moderate to severe ulcerative colitis feel better compared to using each drug alone.

  Recruiting Phase 2 Medical University of Lodz · Lodz · NCT06453317

• Investigating how ustekinumab distributes in inflamed tissues for Crohn's disease and psoriasis

  This study is testing how well the drug ustekinumab works in people with Crohn's disease and psoriasis who haven't found relief from other treatments by looking at where the drug goes in their inflamed tissues.

  Recruiting Phase 1 University Medical Center Groningen · Groningen · NCT05725876

• Evaluating Ustekinumab for Treating Stricturing Crohn's Disease

  This study is testing if ustekinumab can help people with moderate-to-severe Crohn's disease who have blockages in their intestines feel better over a two-year period.

  Recruiting at 8 sites Second Affiliated Hospital, Zhejiang University, School of Medicine · Beijing, Beijing Municipality and 7 other locations · NCT05387031

• Comparing LFMT and placebo for treating ulcerative colitis

  This study is testing whether a new treatment made from processed stool can help people with active ulcerative colitis feel better when they start taking certain medications.

  Recruiting Phase 2 University of Alberta · Edmonton, Alberta · NCT05327790

• Identifying Predictive Markers for Psoriasis Treatment Response

  This study is testing if certain genetic markers can help predict how well people with psoriasis will respond to two different medications over eight weeks.

  Recruiting Phase 4 University Hospitals Cleveland Medical Center · Cleveland, Ohio · NCT05270733

• Assessing the long-term safety of ustekinumab compared to other biologics for Crohn's disease and ulcerative colitis

  This study is testing how safe the drug ustekinumab is compared to other biologic treatments for adults with Crohn's disease or ulcerative colitis over the long term.

  Recruiting Janssen Scientific Affairs, LLC · Houston, Texas · NCT04372108

• Using Vorinostat to Treat Moderate-to-Severe Crohn's Disease

  This study is testing if Vorinostat can help adults with moderate-to-severe Crohn's Disease who haven't found relief from standard treatments.

  Recruiting Phase 1/2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT03167437

Quick answers

How many clinical trials of Ustekinumab are recruiting right now?

22, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 26 countries. The most sites are in China (7 trials), United States (5 trials), France (5 trials), Canada (4 trials), Italy (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 4, Phase 2: 3, Phase 1/2: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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