Clinical trial Recruiting at 1 site Interventional Ages 16 to 60

Comparing two surgical methods for Crohn's disease treatment

Official title: Stapled Antimesenteric Functional End-to-end Anastomosis (Kono-S) Versus Stapled Antimesenteric Isoperistaltic Side-to-side Anastomosis for the Postoperative Recurrence of Crohn's Disease: a Randomized Control Trial Study

Run by Jinling Hospital, China · NCT05658081 · Data updated 2026-11-12

This study is testing which of two surgical methods works better for treating Crohn's disease in patients needing bowel surgery to see which one leads to fewer problems after the operation.

Quick facts

Study typeInterventional
Ages16 Years to 60 Years
SexAll
Enrollment236 (estimated)
SponsorJinling Hospital, China
Academic / other
Locations1 site (Nanjing, Jiangsu)
StatusRecruiting
StartedDecember 8, 2022
Main results expectedDecember 2024
Study endsDecember 2029
Registry record updatedDecember 20, 2022
Trial IDNCT05658081 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are patients with Crohn's disease who require bowel resection and anastomosis.

Probably not a fit

Patients who have undergone enterostomy or small bowel anastomosis, or those anticipating participation in another trial, may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to compare the effectiveness of two different surgical techniques for performing anastomosis in patients with Crohn's disease who require bowel resection. One method involves a stapled anti-mesenteric functional end-to-end anastomosis, while the other uses a stapled antimesenteric isoperistaltic side-to-side anastomosis. The study will evaluate the postoperative recurrence rates of Crohn's disease associated with each technique. By determining which method is superior, the trial seeks to improve surgical outcomes for patients with this chronic condition.

Why it matters

Potential benefit: If successful, this study could lead to reduced recurrence rates of Crohn's disease after surgery, improving patient quality of life.

How similar studies have gone: While the specific comparison of these two anastomosis techniques may be novel, previous studies have shown varying success with different surgical approaches for Crohn's disease.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* patients with Crohn's disease needing bowel resection and anastomosis;
* ileocolic anastomosis;
* written consent acquired

Exclusion Criteria:

* patients underwent enterostomy;
* small bowel anastomosis;
* anticipating other trial.

Where it's running

  • Department of General Surgery, Jinling hosptal,Medical School of Nanjing University
    Nanjing, Jiangsu, China
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.