Identifying gut bacteria linked to spondyloarthritis in Crohn's disease patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The MICROSPA project aims to analyze the gut microbiota, serum cytokines, and peripheral blood mononuclear cells (PBMC) in patients with Crohn's disease (CD) and/or spondyloarthritis (SpA). It will compare three groups: those with CD alone, those with SpA alone, and those with both conditions, alongside a healthy control group. The study will utilize next-generation sequencing (NGS) to determine the composition of fecal microbiota, including bacteriome, virome, and fungome, to identify potential biomarkers associated with these diseases.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18 years.
* Patients will be recruited according to 3 groups:
* Patients with Crohn's disease and axial spondyloarthritis according to the criteria below.
* Patients with Crohn's disease (MC patients) with a diagnosis established according to clinical, biological criteria, radiological, endoscopic and / or histological studies for 3 months. With diagnosis of exclusion of a spondyloarthritis on criteria ASAS and / or New York modified.
* Patients with axial spondyloarthritis (SpA patients) with a diagnosis based on modified ASAS and / or New York criteria with exclusion diagnosis of Crohn's disease.
* Patient with the ability to give free and express informed consent.

Exclusion Criteria:

* History of colonic resection
* Taking antibiotics or colon preparation for colonoscopy within 8 weeks before stool collection (Temporary contraindication = removal possible before colic or first bowel preparation after the start of colonic preparation).
* Ostomy at the time of sampling
* BMI\> 30
* extreme diet
* unbalanced diabetes
* Pregnant woman
* Patient under guardianship, under curatorship or under the protection of justice Contacts/Locations Central Contact

Where it's running

• Central Hospital
  Nancy, Lorraine, France Recruiting
• Saint Antoine Hospital
  Paris, France Recruiting

Study contacts

• Study coordinator: Laurent MD PEYRIN-BIROULET, PhD
• Email: peyrinbiroulet@gmail.com
• Phone: 0383153661

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.