Tissue repair in inflammatory bowel disease using organoid technology

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will collect inflamed and non-inflamed colonic tissue from adult IBD patients and from colonoscopy controls during routine colonoscopy or surgical resection. They will grow intestinal epithelial organoids from these samples and expose them to inflammatory conditions in the lab to observe barrier repair and regeneration processes. The team will analyze cellular, cytokine, and metabolic pathways that influence epithelial healing using molecular and imaging techniques. No experimental treatment is given to participants; the work is laboratory-based and aimed at informing future therapeutic strategies.

Why it matters

Who can join: the full rules

For IBD group the inclusion criteria will be:

* Patients of either sex aged 18 years or older
* Patient that have read the information form and signed consent
* Patient covered with health insurance
* Patients with Crohn's Disease or ulcerative colitis in accordance with accepted clinical, endoscopic, histological and/or radiologic criteria, regardless of the level, severity of the disease or duration of disease progression.
* Patients with colonic involvement of Crohn's disease or ulcerative colitis
* Patients undergoing a screening colonoscopy in the context of IBD disease follow-up OR undergoing intestinal resection for IBD disease aggravation

For control group the inclusion criteria will be:

* Patients of either sex aged 18 years or older
* Patient that have read the information form and signed consent
* Patient covered with health insurance
* Patients undergoing a screening colonoscopy in the context of a family history of colonic neoplasia, follow-up of colonic polyps or functional intestinal disorders OR undergoing intestinal resection for intestinal neoplasia, occlusive syndrome or colostomy

The non-inclusion criteria for IBD group will be:

* Contraindication to the anaesthetic or colonoscopy procedure
* Patients without colonic involvement of Crohn's disease or ulcerative colitis
* Patients of Adults without legal capacity
* Patients in Health and Social Establishments
* Persons in emergency situations
* Persons deprived of their liberty
* Non-affiliated to a social security scheme
* Absence or refusal of the informed consent

The non-inclusion criteria for control group will be:

* IBD disease revealed during colonoscopy or gastrointestinal resection
* Patient suffering from Immune-Mediated Inflammatory Diseases (IMIDs)
* Contraindication to the anaesthetic or colonoscopy procedure
* Patients of Adults without legal capacity
* Patients in Health and Social Establishments
* Persons in emergency situations
* Persons deprived of their liberty
* Non-affiliated to a social security scheme
* Absence or refusal of the informed consent

Where it's running

• Nord Hospital
  Marseille, France Recruiting

Study contacts

• Study coordinator: Lucas GUILLO
• Email: promotion.interne@ap-hm.fr
• Phone: 0491335817

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.