Tissue repair in inflammatory bowel disease using organoid technology
Study of Tissue Repair in Inflammatory Bowel Disease Exploiting Organoid Technology
This project will try organoid techniques on intestinal samples from adults with Crohn's disease or ulcerative colitis to see how their gut lining repairs after inflammation.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Assistance Publique Hopitaux De Marseille Academic / other |
| Locations | 1 site (Marseille) |
| Trial ID | NCT06805890 on ClinicalTrials.gov |
What this trial studies
Researchers will collect inflamed and non-inflamed colonic tissue from adult IBD patients and from colonoscopy controls during routine colonoscopy or surgical resection. They will grow intestinal epithelial organoids from these samples and expose them to inflammatory conditions in the lab to observe barrier repair and regeneration processes. The team will analyze cellular, cytokine, and metabolic pathways that influence epithelial healing using molecular and imaging techniques. No experimental treatment is given to participants; the work is laboratory-based and aimed at informing future therapeutic strategies.
Who should consider this trial
Good fit: Adults (18+) with colonic Crohn's disease or ulcerative colitis who are scheduled for colonoscopy or intestinal resection, and adults undergoing screening colonoscopy as controls, are the ideal candidates.
Not a fit: People without colonic involvement, those not undergoing colonoscopy or resection, or anyone expecting direct therapeutic benefit from participation are unlikely to receive personal benefit.
Why it matters
Potential benefit: If successful, the findings could reveal targets to improve intestinal healing and lead to new treatments that restore the gut lining in IBD patients.
How similar studies have performed: Organoid-based research has yielded promising mechanistic insights into intestinal repair in preclinical studies, but clinical translation into therapies remains at an early stage.
Eligibility criteria
Show full inclusion / exclusion criteria
For IBD group the inclusion criteria will be: * Patients of either sex aged 18 years or older * Patient that have read the information form and signed consent * Patient covered with health insurance * Patients with Crohn's Disease or ulcerative colitis in accordance with accepted clinical, endoscopic, histological and/or radiologic criteria, regardless of the level, severity of the disease or duration of disease progression. * Patients with colonic involvement of Crohn's disease or ulcerative colitis * Patients undergoing a screening colonoscopy in the context of IBD disease follow-up OR undergoing intestinal resection for IBD disease aggravation For control group the inclusion criteria will be: * Patients of either sex aged 18 years or older * Patient that have read the information form and signed consent * Patient covered with health insurance * Patients undergoing a screening colonoscopy in the context of a family history of colonic neoplasia, follow-up of colonic polyps or functional intestinal disorders OR undergoing intestinal resection for intestinal neoplasia, occlusive syndrome or colostomy The non-inclusion criteria for IBD group will be: * Contraindication to the anaesthetic or colonoscopy procedure * Patients without colonic involvement of Crohn's disease or ulcerative colitis * Patients of Adults without legal capacity * Patients in Health and Social Establishments * Persons in emergency situations * Persons deprived of their liberty * Non-affiliated to a social security scheme * Absence or refusal of the informed consent The non-inclusion criteria for control group will be: * IBD disease revealed during colonoscopy or gastrointestinal resection * Patient suffering from Immune-Mediated Inflammatory Diseases (IMIDs) * Contraindication to the anaesthetic or colonoscopy procedure * Patients of Adults without legal capacity * Patients in Health and Social Establishments * Persons in emergency situations * Persons deprived of their liberty * Non-affiliated to a social security scheme * Absence or refusal of the informed consent
Where this trial is running
Marseille
- Nord Hospital — Marseille, France (Recruiting)
Study contacts
- Study coordinator: Lucas GUILLO
- Email: promotion.interne@ap-hm.fr
- Phone: 0491335817
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.