Drug or treatment

Guselkumab clinical trials

• 33Clinical trials
• 30Countries

Newest trials

All recruiting trials (33)

• Long-Term Guselkumab Use in Adults with Inflammatory Bowel Disease

  This study looks at how long adults with Crohn's disease or ulcerative colitis stay on guselkumab in real-world care.

  Recruiting Janssen Research & Development, LLC · Amiens · NCT07822529

• Colonic delivery of two antibodies to see if they reach the bloodstream in healthy people

  This early study tests whether guselkumab and adalimumab given directly into the colon can enter the body in healthy adults.

  Recruiting Phase 1 Surmount Services, Inc. · Maroochydore, Queensland · NCT07788807

• Guselkumab after Ustekinumab in adults with moderate-to-severe psoriasis in routine care

  This study looks at how well guselkumab works for people with moderate-to-severe psoriasis after switching from ustekinumab in everyday clinical practice.

  Recruiting Janssen-Cilag Kft. · Budapest · NCT07746583

• Guselkumab in Moderate-to-Severe Ulcerative Colitis: Real-World Experience

  This real-world study tests whether guselkumab helps adults with moderate-to-severe ulcerative colitis and how safe it is for them.

  Recruiting Second Affiliated Hospital of Wenzhou Medical University · Wenzhou, Zhejiang · NCT07726888

• Guselkumab in Crohn's Disease: Optimising Care for Real-World Patients (OPTIM Study A)

  This study tests whether guselkumab can help adults with Crohn's disease, including those who have had prior therapies or partial responses, when used in real-world clinical settings.

  Recruiting Phase 4 Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives · Amiens · NCT07616687

• Guselkumab use in Crohn's disease and ulcerative colitis

  This study looks at how long people with moderate-to-severe Crohn's disease or ulcerative colitis stay on guselkumab in real-world care.

  Recruiting Janssen-Cilag Pharma GmbH · Vienna · NCT07606339

• Persistence on Guselkumab in Romanian adults with moderate-to-severe plaque psoriasis

  This study looks at how many adults with moderate-to-severe plaque psoriasis continue guselkumab treatment over two years in Romania.

  Recruiting at 20 sites Janssen Research & Development, LLC · Bârlad and 19 other locations · NCT07582783

• Guselkumab in Ulcerative Colitis and Crohn’s Disease in Saudi Arabia: Real-World Use

  This study looks at how long people with moderate-to-severe Crohn’s disease or ulcerative colitis continue taking guselkumab in everyday clinical practice in Saudi Arabia.

  Recruiting Janssen Research & Development, LLC · Jeddah · NCT07541261

• Higher-dose, less-frequent guselkumab versus the usual dose for moderate-to-severe plaque psoriasis in Chinese adults

  This will test whether a higher dose given less often of guselkumab works as well and is as safe as the usual dosing for Chinese adults with moderate-to-severe plaque psoriasis.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07532486

• One-year guselkumab use in adults with psoriatic arthritis

  This project will see how long adults with psoriatic arthritis stay on guselkumab over one year when prescribed as part of routine care.

  Recruiting Janssen-Cilag Ltd. · Lille · NCT07532226

• Real-world use of guselkumab in Crohn’s disease and ulcerative colitis

  This study tests how long guselkumab stays in the bodies of adults with moderate-to-severe Crohn’s disease or ulcerative colitis treated in real-world clinical settings.

  Recruiting Janssen-Cilag A.G., Switzerland · Bern · NCT07532213

• Guselkumab versus risankizumab for moderate-to-severe Crohn's disease

  This comparison tests whether guselkumab or risankizumab works better to reduce intestinal inflammation in people with moderately to severely active Crohn's disease.

  Recruiting at 162 sites Phase 3 Janssen Research & Development, LLC · Dothan, Alabama and 163 other locations · NCT07499232

• Guselkumab for adults with Crohn's disease after ustekinumab failure

  This study will try guselkumab for adults with moderate to severe Crohn's disease who did not respond to or could not tolerate ustekinumab to see if they reach remission after 52 weeks.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07487480

• Guselkumab plus a JAK inhibitor for difficult-to-treat inflammatory bowel disease

  This project will try guselkumab together with a JAK inhibitor in people aged 14–80 whose moderate-to-severe inflammatory bowel disease has not responded to multiple other treatments.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07487311

• Guselkumab vs Ustekinumab for stricturing Crohn's disease

  This study will follow adults with moderate-to-severe Crohn's disease and confirmed intestinal strictures to see if treatment with guselkumab or ustekinumab better controls obstructive symptoms and disease activity.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07444060

• Adjusting guselkumab dosing schedules for adults with plaque psoriasis

  This project will see if adults with plaque psoriasis who are doing well on guselkumab can safely have their injections spaced farther apart than nine weeks.

  Recruiting Centre Hospitalier Universitaire de Nice · Nice, Alpes Maritimes · NCT07430319

• Guselkumab for Chinese patients with Crohn's disease who stopped responding to ustekinumab

  This study tests whether guselkumab can help Chinese patients with active Crohn's disease who initially responded to ustekinumab but later lost response.

  Recruiting at 5 sites Phase 4 Xian-Janssen Pharmaceutical Ltd. · Guangzhou and 4 other locations · NCT07310095

• Guselkumab for Chinese patients with moderate-to-severe ulcerative colitis in routine care

  This project will try guselkumab in Chinese adults with moderate-to-severe ulcerative colitis who have never used biologic therapies to see how their symptoms, endoscopic appearance, and quality of life change in routine clinical care.

  Recruiting at 11 sites Xian-Janssen Pharmaceutical Ltd. · Beijing and 10 other locations · NCT07302360

• Using ultrasound and protein tests to see who responds to guselkumab for ileal Crohn's disease

  This project will try to see if intestinal ultrasound plus blood and tissue protein signatures can show who responds to the medicine guselkumab in adults with ileal Crohn's disease, with or without strictures.

  Recruiting University of Calgary · Calgary, Alberta · NCT07246460

• Switching to guselkumab for adults with active IBD after ustekinumab

  We will try guselkumab (Tremfya) in adults with active IBD whose symptoms didn't improve enough on ustekinumab.

  Recruiting at 12 sites TIDHI Innovation Inc. · Calgary, Alberta and 13 other locations · NCT07245394

• Real-world use of guselkumab for adults with moderate-to-severe ulcerative colitis and Crohn's disease in the UK

  This project will see how well guselkumab works for adults with moderate-to-severe ulcerative colitis or Crohn's disease who are starting the treatment in routine UK care.

  Recruiting Janssen-Cilag Ltd. · Harrow · NCT07242248

• Guselkumab for people with psoriatic arthritis in routine care

  This study will test whether guselkumab given in routine clinical care reduces joint inflammation in people with psoriatic arthritis using musculoskeletal ultrasound to track changes.

  Recruiting at 20 sites Janssen Research & Development, LLC · Bari and 20 other locations · NCT07220824

• Comparing five advanced treatments for axial spondyloarthritis and psoriatic arthritis

  This project will see how well bimekizumab, risankizumab, guselkumab, upadacitinib, or a TNF inhibitor work for adults with axSpA or PsA who have just started one of these medicines, using medical records and patient surveys.

  Recruiting Adelphi Real World · Bath, Somerset · NCT07166315

• Guselkumab treatment for psoriatic arthritis in Indian participants

  This tests whether guselkumab injections are safe and can help Indian patients with psoriatic arthritis who have not improved with standard treatments.

  Recruiting at 11 sites Phase 4 Johnson & Johnson Private Limited · Ahmedabad and 10 other locations · NCT07141004

• Guselkumab treatment for Crohn's disease and ulcerative colitis in Germany

  This project will try to see how well guselkumab works and how it affects symptoms, quality of life, and daily activities for adults with Crohn's disease or ulcerative colitis receiving routine care in Germany.

  Recruiting Janssen-Cilag G.m.b.H · Berlin · NCT07102368

• Intestinal ultrasound predicts guselkumab response in moderate-to-severe Crohn's disease

  This project will test whether intestinal ultrasound can help predict if guselkumab will work for adults with moderate-to-severe Crohn's disease.

  Recruiting The Third Xiangya Hospital of Central South University · Changsha, Hunan · NCT07034664

• Guselkumab's effect on pain perception in psoriatic arthritis

  This study is testing if Guselkumab can help reduce pain and improve symptoms for people with psoriatic arthritis who haven't responded well to other treatments.

  Recruiting Phase 4 Fondazione Policlinico Universitario Campus Bio-Medico · Rome, Italy · NCT06974474

• Guselkumab and diet for chronic or relapsing pouchitis

  This project will test whether the drug guselkumab plus a high-fruit, low ultra-processed-food diet helps adults with chronic or relapsing pouchitis.

  Recruiting Phase 4 Universitaire Ziekenhuizen KU Leuven · Leuven, Vlaams-Brabant · NCT06916390

• Long-term evaluation of guselkumab for children with inflammatory bowel disease and juvenile arthritis

  This study tests how safe and effective the medication guselkumab is for children with inflammatory bowel disease or juvenile arthritis over a long period of time.

  Recruiting at 53 sites Phase 3 Janssen Research & Development, LLC · Atlanta, Georgia and 52 other locations · NCT06663332

• Guselkumab treatment for Hailey-Hailey disease

  This study is testing if a medication called guselkumab, usually used for psoriasis, can help people with Hailey-Hailey disease improve their skin condition.

  Recruiting Phase 2 Yale University · New Haven, Connecticut · NCT06651489

• Exploring how Guselkumab therapy affects liver and joint health in Psoriatic Arthritis patients with NAFLD

  This study is testing how a treatment called Guselkumab can help people with Psoriatic Arthritis who also have liver problems, to see if it improves their joint and liver health.

  Recruiting University of California, San Diego · San Diego, California · NCT06586281

• Evaluating Guselkumab for Children with Active Crohn's Disease

  This study is testing if a new medication called guselkumab can help children with active Crohn's Disease feel better and improve their symptoms over a year.

  Recruiting at 85 sites Phase 3 Janssen Research & Development, LLC · Los Angeles, California and 84 other locations · NCT05923073

• Examining how Guselkumab affects immune cells in scalp psoriasis

  This study is testing how the medication Guselkumab affects immune cells in people with moderate to severe scalp psoriasis to see how it helps their condition.

  Recruiting Phase 4 University of California, San Francisco · San Francisco, California · NCT05858632

Quick answers

How many clinical trials of Guselkumab are recruiting right now?

33, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 30 countries. The most sites are in China (10 trials), France (7 trials), United States (6 trials), United Kingdom (5 trials), Italy (5 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 6, Phase 3: 3, Phase 1: 1, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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