Condition

Ulcerative Colitis (UC) clinical trials and research

• 64Clinical trials
• 1New in 30 days
• 48Countries

Newest Ulcerative Colitis (UC) clinical trials

All recruiting trials (64)

• MGT-006 safety and dosing study for ulcerative colitis

  This study tests an oral microbiome capsule called MGT-006 to see if it is safe and tolerable in adults with moderately active ulcerative colitis, and whether the gut bacteria engraft after treatment.

  Recruiting at 9 sites Phase 1/2 Metagen Therapeutics, Inc. · Naples, Florida and 11 other locations · NCT07913347

• PALI-2108 vs placebo for moderate to severe ulcerative colitis

  A phase 2 study to see if PALI-2108 helps people with moderate to severe ulcerative colitis more than a placebo.

  Recruiting at 28 sites Phase 2 Palisade Bio · Sun City, Arizona and 114 other locations · NCT07845487

• Nitazoxanide as an add-on therapy for mild-to-moderate ulcerative colitis

  A study tests whether adding nitazoxanide to standard UC treatment helps people with mild-to-moderate ulcerative colitis see more relief.

  Recruiting at 2 sites Phase 2/3 Tanta University · Tanta and 1 other locations · NCT07820046

• Fecal Transplants from Dai vs Han Donors for Ulcerative Colitis

  This study tests whether fecal microbiota transplantation from healthy Dai donors improves symptoms in adults with ulcerative colitis more than transplantation from healthy Han donors.

  Recruiting Phase 2 First Affiliated Hospital of Kunming Medical University · Kunming, Yunnan · NCT07814456

• Familial IBD Early Risk

  This study tests whether clinical, environmental, and immune factors in first-degree relatives of people with Crohn’s disease or ulcerative colitis can predict who will develop IBD.

  Recruiting Seattle Children's Hospital · Seattle, Washington · NCT07791862

• Probiotics and Trace Elements Added to Infliximab in Ulcerative Colitis

  This trial tests whether adding a Lactobacillus probiotic or trace elements to infliximab helps people with ulcerative colitis stay in remission.

  Recruiting Phase 4 National Hepatology & Tropical Medicine Research Institute · Cairo · NCT07758335

• AC-101 tablets in ulcerative colitis: a dose-finding study

  This phase 2b trial tests AC-101 tablets versus placebo in adults with moderately to severely active ulcerative colitis who have not had adequate benefit from prior therapies.

  Recruiting Phase 2 Accro Bioscience (Suzhou) Limited · Guangzhou, Guangdong · NCT07755241

• ONO-6414 safety and PK in healthy adults and adults with active ulcerative colitis

  This study tests the safety, tolerability, and how ONO-6414 behaves in the body when taken by healthy adults and adults with active ulcerative colitis.

  Recruiting Phase 1 Ono Pharmaceutical Co., Ltd. · Miami, Florida · NCT07749768

• Claudin-2 Immunostaining to Detect Active or Inactive Inflammation in IBD Biopsies

  This study tests whether staining for Claudin-2 in intestinal biopsy samples can help identify active vs. inactive inflammation in people with ulcerative colitis or Crohn's disease.

  Recruiting IRCCS Policlinico S. Donato · San Donato Milanese, Mi · NCT07710287

• INT-210 capsules for active ulcerative colitis in adults

  This trial tests whether INT-210 capsules are safe and effective for adults with active ulcerative colitis who have not fully responded to prior treatments.

  Recruiting at 15 sites Phase 1/2 Innatus Therapeutics (Shanghai) Co., Ltd. · Guangzhou, Guangdong and 14 other locations · NCT07692165

• Stop PPI in active IBD: can you safely go without acid-suppressing meds?

  This study tests whether people with inflammatory bowel disease who have been on proton pump inhibitors can stop taking them and still manage their symptoms.

  Recruiting Phase 4 University of Nottingham · Nottingham · NCT07691138

• Biomarker Discovery and Validation Platform for Inflammatory Bowel Disease

  Researchers are testing biomarker models to see if they can measure and predict inflammation and treatment response in people with Crohn's disease, ulcerative colitis, or related IBD.

  Recruiting Sixth Affiliated Hospital, Sun Yat-sen University · Guangzhou, Guangdong and 1 other locations · NCT07686406

• Ponesimod for moderately to severely active ulcerative colitis: a treatment study

  This study tests whether ponesimod can help people with moderately to severely active ulcerative colitis who have not responded well to other treatments.

  Recruiting at 2 sites Phase 3 Vanda Pharmaceuticals · Chula Vista, California and 1 other locations · NCT07686081

• Wearable data to spot IBD flareups in people with ulcerative colitis or Crohn's disease

  This study tests whether heart‑rate variability from participants’ own wearables can help predict IBD flares.

  Recruiting at 2 sites Maastricht University Medical Center · 's-Hertogenbosch and 2 other locations · NCT07647640

• Individualizing Anti-TNF Therapy in IBD

  This study tests whether genetic markers can predict which anti-TNF–naïve IBD patients will respond to their first anti-TNF treatment.

  Recruiting Tel-Aviv Sourasky Medical Center · Tel Aviv · NCT07644117

• BDHK-2009 safety test in healthy adults

  This early-stage test checks if BDHK-2009 tablets are safe and tolerable in healthy adults aged 18–55 compared with placebo.

  Recruiting Phase 1 Benethera (Shaoxing) Biotechnology Co., Ltd. · Hangzhou, Zhejiang · NCT07632573

• LRG levels and IBD activity in European patients

  This study will test whether Leucine-rich α2-glycoprotein (LRG) levels reflect disease activity in adults with Crohn’s or ulcerative colitis who are undergoing routine endoscopy in Europe.

  Recruiting Imelda GI Clinical Research Center · Bonheiden · NCT07621783

• Palmitoylethanolamide in Ulcerative Colitis

  This study tests whether taking palmitoylethanolamide helps people with active mild-to-moderate ulcerative colitis to improve symptoms and quality of life compared with a placebo.

  Recruiting Ain Shams University · Cairo, El-Abbasia · NCT07609810

• Ketogenic versus Carnivore (Lion) diets for inflammatory bowel disease and rheumatoid arthritis

  This trial will test whether a ketogenic diet or a carnivore (lion) diet can reduce symptoms, improve quality of life, and lower inflammation in adults with IBD or rheumatoid arthritis.

  Recruiting Fuller Research Foundation · Charlottesville, Virginia · NCT07524244

• 627 for moderate to severe ulcerative colitis: see if it helps

  This study tests whether 627 can help adults with moderate to severe ulcerative colitis who haven’t fully benefited from other therapies.

  Recruiting Phase 2 Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd. · Guangzhou, Guangdong · NCT07507513

• Upadacitinib with or without vedolizumab for induction in moderate-to-severe ulcerative colitis

  This study tests whether adding vedolizumab to upadacitinib helps adults with moderate-to-severe ulcerative colitis achieve better short-term (8-week) control than upadacitinib alone.

  Recruiting at 6 sites Sixth Affiliated Hospital, Sun Yat-sen University · Foshan, Guangdong and 5 other locations · NCT07442045

• Comparing intestinal ultrasound with colonoscopy and enterography for people with ulcerative colitis and Crohn's disease

  This project will see if intestinal ultrasound (IBUS) can provide the same clinical information as colonoscopy and enterography for people with ulcerative colitis or Crohn's disease while producing a smaller carbon footprint.

  Recruiting at 2 sites Asian Institute of Gastroenterology, India · Hyderabad, Telangana and 1 other locations · NCT07431983

• Selenium supplements for moderate-to-severe ulcerative colitis on advanced therapies

  This trial will see if taking 200 mcg of selenomethionine daily helps adults with moderate-to-severe ulcerative colitis who are starting or switching biologics or other advanced therapies.

  Recruiting Phase 2 Northwestern University · Chicago, Illinois · NCT07427017

• Oral LY4268989 for adults with moderate to severe ulcerative colitis.

  This tests whether an oral medicine called LY4268989 helps adults with moderate to severe ulcerative colitis more than a placebo.

  Recruiting at 197 sites Phase 2 Eli Lilly and Company · Phoenix, Arizona and 257 other locations · NCT07415044

• How uneven diet and lifestyle may trigger IBD in adolescents and adults

  See if switching to a Mediterranean-style 'Nordiet' helps young adults with moderately active Crohn's disease or ulcerative colitis reduce gut inflammation and feel better.

  Recruiting Region Skane · Malmö · NCT07389161

• MB-001 treatment for moderate to severe ulcerative colitis

  This trial will try a once-daily oral medicine called MB-001 versus placebo in adults with moderate-to-severe ulcerative colitis to see if it reduces symptoms and inflammation in the colon.

  Recruiting at 7 sites Phase 1/2 Mage Biologics · Tbilisi and 6 other locations · NCT07374471

• Choosing continued advanced medicines or colectomy for ulcerative colitis

  This project will see if people with ulcerative colitis who have failed at least two advanced medicines have better quality of life and satisfaction when they continue medical therapy versus when they have a colectomy.

  Recruiting Region Stockholm · Solna, Stockholm County · NCT07347834

• Vancomycin for active ulcerative colitis with primary sclerosing cholangitis

  This study tests whether oral vancomycin can help adults with both ulcerative colitis and primary sclerosing cholangitis more than a placebo over four weeks.

  Recruiting Phase 2 McMaster University · Hamilton, Ontario · NCT07341282

• HSK47388 for adults with moderately to severely active ulcerative colitis

  This trial will test whether HSK47388 helps adults with moderately to severely active ulcerative colitis control inflammation and symptoms better than a placebo.

  Recruiting Phase 2 Haisco Pharmaceutical Group Co., Ltd. · Hangzhou · NCT07335055

• Desloratadine added to mesalamine for adults with mild to moderate ulcerative colitis

  This trial will test whether adding the antihistamine desloratadine to standard mesalamine therapy helps reduce inflammation and disease activity in adults with mild to moderate ulcerative colitis.

  Recruiting Phase 2 Tanta University · Shibīn al Kawm, Menofia · NCT07333716

• CEDUR — German inflammatory bowel disease registry

  This registry collects real-world health and treatment information from adults with Crohn's disease, ulcerative colitis, or indeterminate colitis in Germany to see how care, effectiveness, safety, and costs play out in routine practice.

  Recruiting ImmunoRegister gUG · Hamburg · NCT07319442

• Reducing ustekinumab dosing for Crohn's disease and ulcerative colitis

  This will try giving ustekinumab less often—changing from every 4 or 8 weeks to every 8 or 12 weeks—to see if people with Crohn's disease or ulcerative colitis in deep remission can stay well.

  Recruiting Phase 4 McGill University Health Centre/Research Institute of the McGill University Health Centre · Montreal, Quebec · NCT07303686

• Gut bacteria and immune-cell energy in people with IBD and healthy adults

  We will test whether gut bacteria change how immune cells use energy in people with Crohn's disease or ulcerative colitis and in healthy adults by using a short antibiotic course and a labeled fiber.

  Recruiting Phase 2 Assistance Publique - Hôpitaux de Paris · Paris · NCT07300553

• Ozanimod versus azathioprine for steroid-dependent ulcerative colitis

  This study will see if ozanimod works better than azathioprine for adults in Japan who are dependent on high-dose steroids for ulcerative colitis.

  Recruiting at 13 sites Bristol-Myers Squibb · Chiba, Chiba and 17 other locations · NCT07271069

• Long-term effectiveness and safety of fecal microbiota transplantation

  This project will follow about 4,000 people who have had fecal microbiota transplantation to see if it helps keep them in remission and is safe over 3 months, 1 year, and 5 years for conditions like recurrent C. difficile, IBD, IBS, and chronic constipation.

  Recruiting Shanghai 10th People's Hospital · Shanghai, Shanghai Municipality · NCT07261826

• Switching to guselkumab for adults with active IBD after ustekinumab

  We will try guselkumab (Tremfya) in adults with active IBD whose symptoms didn't improve enough on ustekinumab.

  Recruiting at 12 sites TIDHI Innovation Inc. · Calgary, Alberta and 13 other locations · NCT07245394

• Zymfentra (infliximab-dyyb) real-world cohort

  This project will see if Zymfentra (infliximab-dyyb) reduces symptoms over one year in adults with Crohn's disease, ulcerative colitis, or indeterminate colitis who are starting or switching to the drug as part of routine care.

  Recruiting at 11 sites University of North Carolina, Chapel Hill · New Haven, Connecticut and 10 other locations · NCT07237516

• Early mirikizumab versus azathioprine for newly diagnosed moderate-to-severe ulcerative colitis

  This trial will test whether starting mirikizumab right away instead of beginning with azathioprine helps people newly diagnosed with moderate-to-severe ulcerative colitis who did not respond well to mesalazine and steroids.

  Recruiting Phase 4 University Hospital Schleswig-Holstein · Kiel · NCT07235904

• Reducing ultra-processed foods in children and teens with IBD

  This project will test whether short nutrition handouts or handouts plus a brief video can help children and teens with IBD eat fewer ultra-processed foods.

  Recruiting Connecticut Children's Medical Center · Hartford, Connecticut · NCT07224113

• SMART-IBD app for teens with inflammatory bowel disease

  This will test whether the SMART-IBD smartphone app helps adolescents ages 13–17 with IBD take their medicines and manage symptoms better than completing daily diaries alone.

  Recruiting Children's Hospital Medical Center, Cincinnati · Cincinnati, Ohio · NCT07195123

• Microplastic levels in children with and without inflammatory bowel disease

  This project will test whether children with Crohn's disease or ulcerative colitis have higher levels of microplastics in intestinal tissue, stool, urine, or blood than children without IBD.

  Recruiting Medical University of Gdansk · Gdansk · NCT07141238

• Phase 2 testing of new therapies for moderate-to-severe inflammatory bowel disease

  The study will try two experimental medicines, MT-501 and MT-201, to see if they are safe and help adults with moderately to severely active Crohn's disease or ulcerative colitis.

  Recruiting at 66 sites Phase 2 Mirador Therapeutics, Inc. · Birmingham, Alabama and 65 other locations · NCT07113522

• Fecal Biomarker Response to Biologics in Ulcerative Colitis

  This study tests whether early changes in fecal calprotectin and FIT after starting vedolizumab or infliximab can predict later response and healing in adults with moderate-to-severe ulcerative colitis.

  Recruiting Qilu Hospital of Shandong University · Jinan, Shandong · NCT07111572

• Early biomarker changes after standard UC therapy predict relapse in biologic-naive patients

  This study tests whether a >50% drop or normalization in qFIT and fecal calprotectin within 2 weeks of starting conventional UC therapy can predict relapse or need for biologic/JAK therapy within a year in biologic-naive patients.

  Recruiting Qilu Hospital of Shandong University · Jinan, Shandong · NCT07111273

• BCD-261 treatment for moderate to severe ulcerative colitis

  This trial tests whether different doses of BCD-261, an anti‑TL1A monoclonal antibody, can improve symptoms and inflammation in adults 18–75 with moderate to severe ulcerative colitis who have not responded to steroids, immunosuppressants, or biologics.

  Recruiting at 20 sites Phase 2 Biocad · Barnaul, Altayskiy Kray and 19 other locations · NCT07080034

• Smart swallowable pill to measure gut oxidation in colon inflammation and cancer

  This pilot will test whether a swallowed sensor pill can measure gut oxidation levels in people with ulcerative colitis or colorectal cancer before and three months after treatment.

  Recruiting Radboud University Medical Center · Nijmegen, Gelderland · NCT07046468

• TIDHI Healing Circuits mental health program for people with IBD

  This study tests whether Healing Circuits™ delivered by a social worker or via a self-guided online program helps adults with IBD who have moderate anxiety or depression.

  Recruiting TIDHI Innovation Inc. · North York, Ontario · NCT07013578

• Gut microbiome engraftment during FMT in rCDI, UC, and metabolic syndrome

  This study tests how well donor microbes take hold after fecal microbiota transplantation in adults with recurrent C. difficile infection, ulcerative colitis, or metabolic syndrome.

  Recruiting Catholic University of the Sacred Heart · Rome, RM · NCT06992453

• First-line biologic choice for moderate-to-severe ulcerative colitis: infliximab versus vedolizumab

  This will test whether infliximab or vedolizumab works better as the first biologic for adults aged 18–70 with moderate-to-severe ulcerative colitis.

  Recruiting Xijing Hospital of Digestive Diseases · Shanxi, Xi'an · NCT06962020

• Monitoring drug levels in children with inflammatory bowel disease

  This study is testing how well certain medications work for children with inflammatory bowel disease by checking their drug levels during treatment.

  Recruiting at 7 sites Medical University Innsbruck · Feldkirch and 9 other locations · NCT06954311

• Adding the Crohn's Disease Exclusion Diet to anti-TNF treatment for Crohn's disease and ulcerative colitis

  This will test whether adding the Crohn's Disease Exclusion Diet to anti‑TNF medicines helps adults with active Crohn's disease or ulcerative colitis.

  Recruiting IRCCS Ospedale San Raffaele · Milan, Michigan · NCT06896305

• Evaluating fecal transplant and diet changes for ulcerative colitis

  This study is testing whether a combination of fecal transplants and an anti-inflammatory diet can help people with newly diagnosed active ulcerative colitis feel better.

  Recruiting All India Institute of Medical Sciences · Kochi, Kerala and 5 other locations · NCT06895252

• Exploring the link between diet and immune-related diseases in families

  This study is trying to see how the diets of families with members who have conditions like Juvenile Idiopathic Arthritis, Crohn's Disease, or Ulcerative Colitis affect their health and treatment options.

  Recruiting at 4 sites Meyer Children's Hospital IRCCS · Florence, Italy and 3 other locations · NCT06862843

• OD-07656 followed by vedolizumab for moderate to severe ulcerative colitis

  This test tries OD-07656, followed by vedolizumab, to see if it improves symptoms in people with moderate to severe ulcerative colitis who have not responded well to other treatments.

  Recruiting at 32 sites Phase 2 Odyssey Therapeutics, Inc. · Birtinya and 31 other locations · NCT06850727

• Optimizing Infliximab Treatment for Inflammatory Bowel Disease

  This study is testing a new way to give infliximab to adults with moderate-to-severe inflammatory bowel disease who haven't improved with steroids, to see if personalized dosing can help them feel better.

  Recruiting Pontificia Universidad Catolica de Chile · Santiago · NCT06758024

• Assessing gut microbiome's role in predicting inflammatory bowel disease progression

  This study is trying to see if the types of bacteria in the gut can help predict how inflammatory bowel diseases like Crohn's disease and ulcerative colitis will progress in the first year after diagnosis.

  Recruiting Pontificia Universidad Catolica de Chile · Santiago · NCT06756100

• AI-based imaging score for assessing ulcerative colitis

  This study is testing a new scoring system using advanced imaging techniques to see if it can better assess the condition of the colon in people with ulcerative colitis compared to current methods.

  Recruiting at 2 sites University College Cork · Leuven and 10 other locations · NCT06709209

• Investigating the effects of a blueberry-rich diet on colitis

  This study is testing if eating a diet high in blueberries can help people with ulcerative colitis and Crohn's disease feel better by improving their gut health and reducing inflammation.

  Recruiting Universität Duisburg-Essen · Bamberg, Bavaria · NCT06698601

• De-escalating treatment for ulcerative colitis when biopsies show no inflammation

  This will see if people with ulcerative colitis whose biopsies show no inflammation can safely reduce or stop their medications without losing remission.

  Recruiting University of Chicago · Chicago, Illinois · NCT06693310

• Tracking family members at risk for inflammatory bowel disease

  This study is trying to see if tracking family members of people with inflammatory bowel disease can help find out who is at risk of developing it and how to prevent it.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT06655415

• Evaluating XmAb942 in Healthy Individuals and Those with Ulcerative Colitis

  This study is testing a new drug called XmAb942 in healthy people and those with ulcerative colitis to see how safe it is and how well it works.

  Recruiting at 112 sites Phase 1/2 Xencor, Inc. · Scottsdale, Arizona and 113 other locations · NCT06619990

• Fluorescence imaging of a drug for inflammatory bowel disease

  This study is testing a special version of a drug for inflammatory bowel disease to see how well it targets the right areas in the body and to find the best dose for patients.

  Recruiting Phase 1/2 University Medical Center Groningen · Groningen · NCT06606808

• Combining Vedolizumab and Upadacitinib for Ulcerative Colitis Treatment

  This study is testing if combining two medications, Vedolizumab and Upadacitinib, can help people with moderate to severe ulcerative colitis feel better faster and stay well longer.

  Recruiting Sixth Affiliated Hospital, Sun Yat-sen University · Guangzhou, Guangdong · NCT06095596

• Observational cohort for early spondyloarthritis in Germany

  This study is tracking patients with early spondyloarthritis in Germany to see how the disease progresses and affects their quality of life over time.

  Recruiting Charite University, Berlin, Germany · Berlin · NCT01277419

Related topics

Quick answers

How many Ulcerative Colitis (UC) clinical trials are recruiting right now?

64, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 48 countries. The most sites are in United States (15 trials), China (14 trials), Canada (9 trials), Italy (7 trials), Poland (6 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 13, Phase 1/2: 5, Phase 4: 4, Phase 1: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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