Condition

Atrial Fibrillation (AF) clinical trials and research

• 137Clinical trials
• 3New in 30 days
• 54Countries

Newest Atrial Fibrillation (AF) clinical trials

All recruiting trials (137)

• Pulsed Field vs Cryoballoon for Pulmonary Vein Isolation in Atrial Fibrillation

  This trial tests whether pulsed field ablation can shorten the procedure for first-time PVI in AF patients compared with cryoballoon ablation, while keeping safety and effectiveness similar.

  Recruiting St. Josefs-Hospital Wiesbaden GmbH · Wiesbaden · NCT07910370

• Pulsed Field Ablation vs Cryoablation for Atrial Fibrillation Under Deep Sedation

  This trial tests whether pulsed field ablation (PFA) done under deep sedation works as well as cryoballoon ablation for treating atrial fibrillation, aiming to avoid general anesthesia.

  Recruiting East Sussex Healthcare NHS Trust · Eastbourne · NCT07900685

• Bachmann’s Bundle Pacing vs Right Atrial Appendage Pacing for AF

  This study tests two common atrial pacing methods to see which one is safer over 12 months for people getting a new pacemaker, ICD, or CRT device.

  Recruiting Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) · Pittsburgh, Pennsylvania · NCT07874763

• AI-powered ECG to help diagnose and predict outcomes in heart disease

  Researchers test an AI-enhanced ECG to help diagnose and predict outcomes for people with cardiovascular diseases.

  Recruiting Inha University Hospital · Incheon, Incheon · NCT07856472

• Pace-and-ablate strategy in atrial fibrillation: who benefits and long-term outcomes

  This study looks at adults with atrial fibrillation who underwent AV node ablation with permanent pacing to see who develops pacing-induced problems and how they do long-term.

  Recruiting at 5 sites Insel Gruppe AG, University Hospital Bern · Zabrze and 4 other locations · NCT07852221

• AI-based cardiac analysis using 12-lead and 1-lead ECG

  A clinician-facing pilot test to see if SmartECG-EF helps evaluate heart function using both 12-lead and single-lead ECGs in adults with heart conditions.

  Recruiting Inha University Hospital · Incheon, Incheon · NCT07844434

• Long-term half-dose apixaban versus aspirin after Watchman implantation

  This trial tests whether continuing a half-dose blood thinner (apixaban) is better than aspirin after Watchman device implantation in people with atrial fibrillation.

  Recruiting Phase 3 Texas Cardiac Arrhythmia Research Foundation · Austin, Texas · NCT07840365

• Factors Linked to Slow Heart Rate After Pulsed Field Ablation for Atrial Fibrillation

  This study looks for factors that might cause bradycardia during the hospital stay after AF ablation using pulsed field technology.

  Recruiting Wroclaw Medical University · Wroclaw, Lower Silesian Voivodeship · NCT07809347

• Finerenone after catheter ablation to see if it reduces AF recurrence

  This pilot study tests whether adding finerenone after first-time AF ablation can lower the chance of AF coming back over 12 months in adults.

  Recruiting Phase 2 National Cheng-Kung University Hospital · Tainan · NCT07799519

• Budiodarone for paroxysmal AF: a dose-escalation safety and feasibility study

  This study tests whether budiodarone is safe and helps control paroxysmal atrial fibrillation in about 100 adults over 6 months, using dose adjustments guided by AF monitoring.

  Recruiting at 4 sites Phase 2 Xyra, LLC · Gdynia and 3 other locations · NCT07792239

• Detecting Atrial Fibrillation with Smartphone Camera Heart Rate Signals

  This study tests whether a smartphone camera-based PPG algorithm can detect atrial fibrillation in adults who are being evaluated for AF, by comparing its output to a standard 12-lead ECG.

  Recruiting at 4 sites Happitech BV · Jonesboro, Arkansas and 4 other locations · NCT07779213

• Blood lipid and ceramide profiles in atrial fibrillation

  This study tests whether blood lipid and ceramide patterns differ between people with atrial fibrillation and those with other heart diseases.

  Recruiting First Affiliated Hospital Xi'an Jiaotong University · Xi'an, Shaanxi · NCT07757282

• Edoxaban vs. Apixaban in AF with CAD: Net Benefit

  This trial tests whether edoxaban-based therapy provides a similar or better overall benefit than apixaban-based therapy for stroke prevention and major bleeding in adults with atrial fibrillation and coronary artery disease.

  Recruiting Phase 4 Samsung Medical Center · Seoul · NCT07753200

• Photoplethysmography-based algorithm to detect atrial fibrillation in heart failure patients

  A wearable-based, AI-powered test using PPG signals to see if a patient with heart failure has atrial fibrillation.

  Recruiting Seerlinq s. r. o. · Bratislava · NCT07749183

• Caffeine and Heart-Rate Control in Permanent Atrial Fibrillation

  This trial tests whether continuing moderate coffee intake affects 24-hour heart-rate control in people with permanent atrial fibrillation who normally use caffeine.

  Recruiting Phase 2/3 Hospital Universitario Getafe · Getafe, Madrid · NCT07738523

• Mild Sedation with Remimazolam and Fentanyl During Pulsed-Field Ablation for Atrial Fibrillation

  This study tests whether a light, monitored sedation with remimazolam and fentanyl during REM (pulsed-field) ablation for AF can replace deeper anesthesia in adults.

  Recruiting Charles University, Czech Republic · Prague · NCT07734194

• Very high-power short-duration vs standard low-power radiofrequency ablation for atrial fibrillation

  This trial tests whether very high-power short-duration ablation (90 W) is as safe and more effective than conventional low-power ablation (35-45 W) for treating atrial fibrillation.

  Recruiting Bakulev Scientific Center of Cardiovascular Surgery · Moscow · NCT07728539

• Personalized AF ablation: anatomy-based vs Emphasize map-guided substrate ablation

  We’re testing two catheter ablation approaches for persistent atrial fibrillation to see which one leads to fewer or shorter episodes of abnormal heart rhythms over a year.

  Recruiting Samsung Medical Center · Seoul, Seoul and 1 other locations · NCT07726901

• Cardiac ablation for endurance athletes with atrial fibrillation

  This study tests whether catheter ablation can help endurance athletes with atrial fibrillation and how it might affect their performance.

  Recruiting at 5 sites University Hospital of Leuven Leuven · Melbourne and 4 other locations · NCT07726056

• Pulsed field ablation for AF: isolated Superior Vena Cava plus Pulmonary Vein isolation

  This study tests a pulsed field ablation approach to treat atrial fibrillation by isolating the pulmonary veins and the superior vena cava in adults who have not responded well to standard medications.

  Recruiting Shenyang Northern Hospital · Chengdu, Sichuan · NCT07724899

• Risk score for predicting embolism in AF patients on DOACs

  This study checks a risk score to see if it can predict embolism in people with atrial fibrillation who are taking direct oral anticoagulants.

  Recruiting at 2 sites Hospital Universitari Vall d'Hebron Research Institute · Barcelona, Barcelona and 1 other locations · NCT07713537

• BodyGuardian Monitoring for Recurrence of Atrial Fibrillation

  This study tests wearing the BodyGuardian monitor after AF ablation to see if it helps track and understand recurrence in patients who had the FARAPULSE PFA system.

  Recruiting at 4 sites Heart Rhythm Clinical and Research Solutions, LLC · Delray Beach, Florida and 4 other locations · NCT07671677

• BDNF Levels and Atrial Cardiomyopathy in People Having AF Ablation

  This study tests whether circulating BDNF levels are linked to atrial cardiomyopathy in adults having their first ablation for persistent atrial fibrillation.

  Recruiting Centre Hospitalier Universitaire Dijon · Dijon · NCT07648329

• Predicting Atrial Fibrillation with a Genetic Risk Score

  Researchers test whether a polygenic risk score can help flag people likely to have undiagnosed atrial fibrillation, alongside at-home and clinic heart monitoring.

  Recruiting at 5 sites Seoul St. Mary's Hospital · Incheon and 4 other locations · NCT07641582

• Personalized Atrial Fibrillation Ablation Using Unipolar QS-Potential Mapping

  In people with atrial fibrillation who are having catheter ablation, this study tests whether guiding the procedure with unipolar QS-potential mapping can improve outcomes compared with standard pulmonary vein isolation.

  Recruiting China National Center for Cardiovascular Diseases · Beijing, Beijing Municipality · NCT07630857

• Preventing stroke and systemic embolism in adults with atrial fibrillation using REGN7508 compared with apixaban

  This trial tests REGN7508 in adults with atrial fibrillation to see if it can prevent stroke and blood clots better or as well as apixaban.

  Recruiting at 66 sites Phase 3 Regeneron Pharmaceuticals · Alexander City, Alabama and 65 other locations · NCT07626411

• Remapping Before/During LAAO: Testing Durable Pulsed Field Ablation for Atrial Fibrillation

  We’re testing whether a pulsed field ablation done during a planned left atrial appendage occlusion procedure stays effective over time in adults with atrial fibrillation.

  Recruiting Northwell Health · Bay Shore, New York · NCT07620262

• Intensive lifestyle changes after AF ablation in people who are overweight

  The study tests whether an intensive diet and exercise program after AF ablation helps overweight patients do better than standard follow-up care.

  Recruiting National Taiwan University Hospital · Taipei · NCT07618741

• What happens to the tricuspid valve in atrial fibrillation patients without strong valve leakage

  This study looks at how the tricuspid valve changes over a year in people with atrial fibrillation who don’t have significant valve leakage, using 3D heart imaging.

  Recruiting Centro Cardiologico Monzino · Milan, Milan · NCT07617974

• Screening for heart failure in older adults with atrial fibrillation in rural China

  We’re testing whether HF screening in 65–80 year olds with AF in rural China can help identify heart failure early and track progression over time.

  Recruiting Jiangsu Taizhou People's Hospital · Taizhou, Jiangsu · NCT07611084

• Optimal shock energy for electrical cardioversion of atrial fibrillation

  This study tests whether starting with a higher initial shock energy for electrical cardioversion helps restore normal rhythm in people with atrial fibrillation.

  Recruiting Motol and Homolka University Hospital · Prague · NCT07610980

• Early rhythm control in atrial fibrillation with tricuspid regurgitation

  This study tests whether starting rhythm control early in people with atrial fibrillation and tricuspid regurgitation can improve outcomes compared with usual care.

  Recruiting Samsung Medical Center · Seoul, Seoul · NCT07607093

• Pulsed Field Ablation Outcomes in Atrial Fibrillation: Randomized Comparison to Traditional Ablation

  This study tests pulsed field ablation versus conventional radiofrequency ablation in adults with atrial fibrillation to see which method better preserves heart rhythm.

  Recruiting China National Center for Cardiovascular Diseases · Beijing, Beijing Municipality · NCT07601763

• Low-intensity ultrasound to calm the nerves and improve sleep after heart surgery

  This trial tests whether gentle, focused ultrasound on the left stellate ganglion can improve autonomic function and sleep after heart-related surgery in adults with cardiovascular disease, compared with a sham treatment.

  Recruiting Renmin Hospital of Wuhan University · Huangshi, Hubei and 6 other locations · NCT07595068

• Sex-based differences in AF wiring and how they affect outcomes

  This study tests whether women have more unmapped extra-pulmonary AF triggers than men during a first-time AF ablation.

  Recruiting Assaf-Harofeh Medical Center · Be’er Ya‘aqov · NCT07580547

• Genetic testing for AF-triggered cardiomyopathy

  We will test whether people who develop heart failure during atrial fibrillation carry specific disease-causing gene variants compared with people who have AF but do not weaken their heart.

  Recruiting Barts & The London NHS Trust · London · NCT07574697

• Comparison of Optrell and Octaray Mapping Catheters for Atrial Ablation

  This study tests whether the Optrell catheter with V8 software can confirm conduction block during atrial ablation and compares voltage readings with Octaray in adults with atrial fibrillation.

  Recruiting Assaf-Harofeh Medical Center · Be’er Ya‘aqov · NCT07563257

• Left Atrial Appendage Occlusion and Rhythm Restoration in AF Patients

  This trial tests a combined procedure using the Volt PFA System and Amulet 2 to see if it safely and feasibly treats atrial fibrillation while also closing the left atrial appendage in adults with AF.

  Recruiting at 13 sites Abbott Medical Devices · Brussels, B CAP R and 15 other locations · NCT07523620

• Remote ECG monitoring after TAVI

  This compares continuous 30-day remote ECG monitoring to standard short-term monitoring for adults after TAVI to see if it detects rhythm problems earlier.

  Recruiting at 3 sites Medical University of Silesia · Turin and 3 other locations · NCT07521800

• Early return of atrial fibrillation after pulsed field ablation and long‑term risk

  We will see if early return of AF after pulsed field ablation predicts later recurrence in adults having their first ablation.

  Recruiting West China Hospital · Chengdu, Sichuan · NCT07518966

• Somatic health screening for adults in psychiatric outpatient care

  This program tries adding regular physical-health screening into psychiatric outpatient care to see if it helps detect and manage heart disease, lung disease, diabetes, and other conditions in adults with psychotic or affective disorders.

  Recruiting Amager Hospital · Copenhagen · NCT07518446

• AccuSafe guidewire vs traditional transseptal needle for X-ray-free transseptal puncture during AF ablation

  This tests whether the AccuSafe transseptal guidewire is safer and more effective than the traditional transseptal needle for people with atrial fibrillation undergoing catheter ablation guided by intracardiac echocardiography without X-rays.

  Recruiting Second Affiliated Hospital of Nanchang University · Nanchang, Jiangxi · NCT07515040

• Empagliflozin to improve left atrial function in people with paroxysmal atrial fibrillation, hypertension, and abnormal glucose metabolism

  This trial tests whether taking empagliflozin once daily for 12 months can improve left atrial function in adults with paroxysmal atrial fibrillation, hypertension, and diabetes or prediabetes.

  Recruiting Phase 2 Huashan Hospital · Shanghai, Shanghai Municipality · NCT07482020

• Understanding why AF happens and is harder to treat in hypertrophic cardiomyopathy

  We’re testing how heart electrical signals and advanced imaging relate to atrial fibrillation in people with hypertrophic cardiomyopathy to see if treatments can be improved.

  Recruiting Guy's and St Thomas' NHS Foundation Trust · London · NCT07454135

• Early rhythm control treatment for subclinical atrial fibrillation

  This study tests whether starting rhythm-control treatments early can reduce abnormal heart rhythm episodes in people whose subclinical atrial fibrillation was found by implantable heart devices.

  Recruiting Samsung Medical Center · Seoul, Seoul · NCT07447297

• Start CPAP After AF Ablation in OSA Patients

  This study tests whether adding CPAP after AF ablation helps prevent atrial arrhythmia recurrence in adults with obstructive sleep apnea.

  Recruiting at 3 sites Beijing Anzhen Hospital · Beijing, Beijing Municipality and 29 other locations · NCT07444372

• TH-75 blood pressure monitor for detecting atrial fibrillation

  We will test whether the TH-75 blood pressure monitor can detect atrial fibrillation in adults with or without a prior AF diagnosis.

  Recruiting Andon Health Co., Ltd · Tianjin, Tianjin Municipality · NCT07442175

• Catheter ablation plus LAAC vs anticoagulation in frail elderly A-fib patients

  This study tests whether adding left atrial appendage closure to ablation is as good as using long-term blood thinners in frail people aged 75 and up with atrial fibrillation.

  Recruiting Guangdong Provincial People's Hospital · Guangzhou, Guangdong · NCT07441382

• Left atrial and appendage function after pulsed-field pulmonary vein isolation in paroxysmal AF

  We will test whether pulsed-field pulmonary vein isolation causes immediate changes in left atrial and left atrial appendage function in adults with paroxysmal atrial fibrillation.

  Recruiting Charles University, Czech Republic · Prague · NCT07439016

• New ways to estimate left heart pressures in people with heart failure and atrial fibrillation

  This study tests a new approach that combines ultrasound and clinical data to see if doctors can better tell when the heart’s filling pressure is high in patients who have both heart failure and atrial fibrillation.

  Recruiting Oslo University Hospital · Cleveland, Ohio and 14 other locations · NCT07436299

• Long-term atrial fibrillation risk after an acute illness

  A small implantable heart monitor will be used to see if adults who develop acute atrial fibrillation—especially after cardiac surgery—have more long-term recurrences than those with AF after non-cardiac surgery or medical illness.

  Recruiting University of California, San Diego · La Jolla, California · NCT07434674

• Preventing stroke and systemic embolism in adults with atrial fibrillation who can't use oral blood thinners

  This trial tests two experimental drugs, REGN7508 and REGN9933, to see if they reduce ischemic stroke or systemic embolism in adults with atrial fibrillation who cannot or choose not to take oral blood thinners.

  Recruiting at 45 sites Phase 3 Regeneron Pharmaceuticals · Dothan, Alabama and 44 other locations · NCT07430956

• Personalized exercise and diet program to reduce atrial fibrillation episodes and heart/body fat

  This 12-month program will try personalized exercise plus dietary counseling to reduce atrial fibrillation episodes, symptoms, and heart and body fat in overweight adults with paroxysmal or persistent AF.

  Recruiting University of Eastern Finland · Jyväskylä, Central Finland and 3 other locations · NCT07430007

• Catheter ablation vs optimized medical care for very elderly with atrial fibrillation

  In people aged 78 and up with AF, this study tests whether catheter ablation can help by comparing it to tailored medical therapy, using a wearable rhythm monitor to track AF over time.

  Recruiting Karolinska University Hospital · Linköping and 1 other locations · NCT07424690

• Extended ablation added to PVI for persistent atrial fibrillation

  In adults with symptomatic persistent AF who are undergoing a first ablation, the study tests whether adding predefined linear ablation lines to pulmonary vein isolation improves freedom from AF/AT/AFL over 12 months.

  Recruiting at 4 sites Charles University, Czech Republic · Olomouc and 3 other locations · NCT07424326

• Post-stroke heart rhythm monitoring with a wearable chest patch in Southern Norway

  This test tries a small wireless chest patch worn up to 14 days to see if it finds atrial fibrillation better than the usual short hospital monitoring in people who recently had an ischemic stroke or TIA.

  Recruiting Sorlandet Hospital HF · Kristiansand · NCT07407790

• Flecainide safety in people with atrial fibrillation and stable coronary artery disease

  This study tests whether flecainide is as safe as standard rhythm-control drugs for adults with atrial fibrillation and stable coronary artery disease.

  Recruiting at 4 sites Phase 4 Universitaire Ziekenhuizen KU Leuven · Aalst and 13 other locations · NCT07405671

• Ablation to improve wellbeing and survival in people aged 80 and older with atrial fibrillation

  This will see if catheter ablation, compared with a sham procedure, improves quality of life over six months for people aged 80 and older with symptomatic atrial fibrillation.

  Recruiting Beijing Anzhen Hospital · Beijing · NCT07403760

• Ablation guided by hierarchical heart electrical patterns to treat atrial fibrillation

  This project will try a targeted ablation guided by models of the heart's electrical organization to see if it reduces arrhythmias in adults with persistent atrial fibrillation or with recurrent ventricular arrhythmias not controlled by medicines.

  Recruiting Hospital San Carlos, Madrid · Madrid, Madrid · NCT07390175

• Reprocessed versus new ablation catheters for pulmonary vein isolation

  This will test whether re-sterilized (reprocessed) ablation catheters work as well and are as safe as new catheters for adults having pulmonary vein isolation for atrial fibrillation.

  Recruiting University Hospital Dubrava · Zagreb · NCT07389434

• Electroporation for early AF treatment in people with HFpEF

  This study will test whether electroporation pulmonary vein isolation using the FARAPULSE system works better than usual medical treatment for people with symptomatic paroxysmal atrial fibrillation who also have HFpEF.

  Recruiting Cardioangiologisches Centrum Bethanien · Frankfurt am Main · NCT07385417

• Safety of perioperative blood thinner management in people with cancer undergoing surgery or procedures

  This study tests how safe current practices are for stopping or continuing blood thinners in adults with cancer who are having surgery or procedures, to see if bleeding or clots are affected.

  Recruiting Ottawa Hospital Research Institute · Ottawa · NCT07372716

• Silent brain lesion monitoring after VARIPULSE pulsed field ablation for atrial fibrillation

  We will see if pulsed field ablation with the VARIPULSE system leads to silent brain lesions on MRI in adults treated for paroxysmal or persistent atrial fibrillation.

  Recruiting Seoul National University Hospital · Seoul, Jongro-ku · NCT07363278

• Left atrial appendage closure with AtriLASH Seralene suture during cardiac surgery for atrial fibrillation

  This trial tests whether closing the left atrial appendage with the AtriLASH Seralene hemostatic suture during cardiac surgery can reduce stroke risk in adults with atrial fibrillation.

  Recruiting Institute of Cardiovascular Diseases, Vojvodina · Kamenitz, Vojvodina · NCT07360899

• Using noninvasive mapping to guide atrial fibrillation ablation

  This will test whether using noninvasive heart mapping to choose personalized ablation targets helps people with persistent atrial fibrillation and enlarged left atria by increasing immediate AF termination and reducing later recurrences.

  Recruiting Hospital Clinic of Barcelona · Barcelona · NCT07358611

• ICE-guided cavotricuspid isthmus ablation with a circular pulsed-field catheter

  This will see if a circular-shaped pulsed field ablation catheter, guided by intracardiac echocardiography, can safely and effectively achieve acute cavotricuspid isthmus ablation in adults with atrial fibrillation.

  Recruiting Beijing Anzhen Hospital · Beijing · NCT07353775

• Concomitant Pulsed Field Ablation and Left Atrial Appendage Closure in AF Patients

  In patients with atrial fibrillation who need both ablation and left atrial appendage closure, this study tests doing both procedures in a single intervention using FARAPULSE PFA and a WATCHMAN FLX device.

  Recruiting at 10 sites Boston Scientific Corporation · Aalst and 10 other locations · NCT07349121

• Atrial fibrillation screening for people with higher-than-median NT-proBNP in Tromsø

  This will test whether giving 7-day wearable ECG monitoring to people aged 40+ with NT-proBNP above the median can find atrial fibrillation and reduce ischemic stroke and vascular deaths compared with no long-term monitoring.

  Recruiting at 2 sites University Hospital of North Norway · Tromsø and 1 other locations · NCT07343895

• Progressive Resistance Training First to Help AF and HFpEF Patients Feel Better

  This trial tests whether starting with progressive resistance training before aerobic exercise can improve exercise capacity and quality of life in people aged 60 and older who have atrial fibrillation and HFpEF.

  Recruiting Northwestern University · Chicago, Illinois · NCT07324772

• Digital MediYoga for quality of life and heart measures in paroxysmal atrial fibrillation

  This trial will test whether a 12-week, app-delivered MediYoga program can improve disease-specific quality of life and reduce blood pressure and heart rate in adults with paroxysmal atrial fibrillation.

  Recruiting Herlev and Gentofte Hospital · Herlev · NCT07321964

• Personalized AF ablation guided by non-invasive global mapping

  This project will test whether using a non-invasive global mapping system to guide personalized additional ablation after standard pulmonary vein isolation helps people with persistent atrial fibrillation and enlarged left atria have fewer recurrences.

  Recruiting German Heart Institute · Berlin and 4 other locations · NCT07320560

• Redo AF ablation using the Sphere-9 catheter and Affera system for recurrent paroxysmal and persistent atrial fibrillation

  The study will try the Sphere-9 catheter with the Affera ablation and mapping systems for adults who have symptomatic recurrent paroxysmal or persistent atrial fibrillation after one prior ablation.

  Recruiting at 24 sites Medtronic Cardiac Ablation Solutions · Birmingham, Alabama and 29 other locations · NCT07298473

• Watchman Elite Left Atrial Appendage Closure Device in AF patients seeking a non-drug option

  This study tests whether the Watchman Elite LAAC device can safely and effectively reduce stroke risk in people with non-valvular atrial fibrillation who want a non-pharmacologic alternative to anticoagulation.

  Recruiting at 2 sites Boston Scientific Corporation · Jonesboro, Arkansas and 1 other locations · NCT07287436

• Atrial fibrillation screening for people with abnormal echocardiograms

  We will see if using certain abnormal echocardiogram measurements to select people for scheduled extended ECG monitoring finds more atrial fibrillation than usual care.

  Recruiting Taipei Veterans General Hospital, Taiwan · Taipei · NCT07278089

• Waiting on Atrial Fibrillation Intervention Therapy: Weight loss before ablation

  This trial tests whether adding weekly semaglutide before first-time AF ablation helps people who are overweight or obese have better rhythm outcomes.

  Recruiting Phase 4 Karolinska University Hospital · Stockholm · NCT07275697

• Ablation versus medication for atrial fibrillation in people with preserved or mildly reduced heart function

  This trial will randomly assign adults with atrial fibrillation and heart failure with preserved or mildly reduced ejection fraction to either catheter ablation (rhythm control) or medications for rate control to see which approach leads to better survival, fewer hospital stays, and improved quality of life.

  Recruiting at 4 sites Nova Scotia Health Authority · Halifax, Nova Scotia and 3 other locations · NCT07272902

• Pre-ablation prehabilitation to improve recovery after atrial fibrillation ablation

  A 4-week supervised program of exercise and psychological education will be tested in people with atrial fibrillation scheduled for their first catheter ablation to see if it improves post-procedure fitness and clinical outcomes compared with usual care.

  Recruiting Nanjing Medical University · Nanjing, Please Select · NCT07270757

• AP31969 versus placebo to control heart rhythm in people with atrial fibrillation

  This trial tests whether taking oral AP31969 twice daily at several doses can lower AF burden compared with a placebo in adults with paroxysmal or persistent atrial fibrillation.

  Recruiting at 38 sites Phase 2 Acesion Pharma · Plovdiv, PD and 45 other locations · NCT07267949

• Effect of pulmonary vein isolation on sleep breathing in people with paroxysmal atrial fibrillation

  This study will test whether pulmonary vein isolation (a common AF ablation) changes sleep breathing measurements in people with paroxysmal atrial fibrillation who have risk factors for sleep apnea.

  Recruiting Primula Clinics · Grodzisk Mazowiecki · NCT07259200

• Left bundle branch pacing versus right ventricular pacing to reduce device‑detected fast atrial episodes in people with preserved ejection fraction

  This trial will test whether left bundle branch pacing (LBBP) reduces the total time people with preserved ejection fraction spend in device‑detected fast atrial episodes compared with standard right ventricular pacing.

  Recruiting University Hospital of Patras · Pátrai · NCT07250529

• Disrupted sleep and irregular heartbeats in people with hypoglossal nerve stimulators

  This study will test whether turning a hypoglossal nerve stimulation (HGNS) device off for a night increases the chance of irregular heartbeats or short atrial fibrillation episodes in adults with obstructive sleep apnea who already have an HGNS implant.

  Recruiting University of California, San Francisco · San Francisco, California · NCT07220525

• Left bundle branch area pacing with Tendril STS or UltiPace leads

  This study will try left bundle branch area pacing with the Tendril STS or UltiPace lead in adults who need pacemaker leads for bradycardia or related heart conditions to see if pacing and sensing are safe and work through six months after implant.

  Recruiting at 13 sites Abbott Medical Devices · Rio de Janeiro, Rio de Janeiro and 14 other locations · NCT07217392

• Tracking outcomes after heart rhythm procedures in Düsseldorf.

  This registry collects information to see how safe and effective routine electrophysiology procedures (like catheter ablation and cardioversion) are for people treated for AF, atrial flutter, supraventricular tachycardias, or VT at University Hospital Düsseldorf.

  Recruiting Heinrich-Heine University, Duesseldorf · Düsseldorf · NCT07196176

• Dapagliflozin to prevent atrial fibrillation coming back after cardioversion

  This trial tests whether taking dapagliflozin once daily can reduce the chance that atrial fibrillation returns after an electric cardioversion in adults aged 55 and older.

  Recruiting at 2 sites Phase 3 Region Stockholm · Linköping and 6 other locations · NCT07187570

• Safety of two new clot-preventing medicines for adults with atrial fibrillation on anticoagulation

  This trial will test two experimental medicines, REGN7508 and REGN9933, against apixaban to see if they prevent clots with acceptable bleeding risk in adults with atrial fibrillation who need long-term anticoagulation.

  Recruiting at 90 sites Phase 2 Regeneron Pharmaceuticals · Dothan, Alabama and 90 other locations · NCT07175428

• Wearable cardiac monitoring for early arrhythmia detection and remote management

  This project will try a smartwatch-based system to spot arrhythmias early and help manage adults with chronic or recently treated heart problems.

  Recruiting University of Sao Paulo · São Paulo, São Paulo · NCT07174206

• Using a pulsed-field balloon catheter to isolate pulmonary veins for atrial fibrillation

  This trial will test whether pulsed field ablation with the VOLT balloon catheter works as well as standard thermal ablation for adults having their first pulmonary vein isolation for atrial fibrillation.

  Recruiting at 2 sites AZ Sint-Jan AV · Bruges and 1 other locations · NCT07156877

• Village-based program to manage chronic heart conditions in Qujiang older adults

  This project will try a village-based program combining medicines, lifestyle support, education, and 7-day ECG monitoring for people aged 60+ in Qujiang with chronic heart conditions such as atrial fibrillation, high blood pressure, coronary artery disease, or heart failure.

  Recruiting Beijing Anzhen Hospital · Beijing, Beijing Municipality · NCT07149688

• Electroporation versus Radiofrequency Ablation Guided by 3D Imaging for Repeat Atrial Fibrillation

  This trial tests whether pulsed field electroporation or standard radiofrequency ablation works better and safer for people having a repeat catheter ablation for recurrent atrial fibrillation.

  Recruiting Wroclaw Medical University · Wroclaw · NCT07141745

• Comparing FARAPULSE and FARAWAVE Nav catheters during pulmonary vein isolation for atrial fibrillation

  This test will see if the FARAWAVE Nav catheter's built-in mapping can be used instead of pre-procedure CT scans for adults having pulmonary vein isolation for atrial fibrillation.

  Recruiting Cardiocentro Ticino · Lugano, Canton Ticino · NCT07130773

• Pulsed field ablation registry for atrial arrhythmias in Poland.

  This project will collect information to see how well pulsed field ablation works and how safe it is for people in Poland having ablation for atrial fibrillation, atrial flutter, or atrial tachycardia.

  Recruiting Wroclaw Medical University · Wroclaw, Lower Silesian Voivodeship · NCT07109141

• Marshall vein ethanol injection plus pulsed-field pulmonary vein isolation for paroxysmal atrial fibrillation

  This trial will test whether injecting ethanol into the vein of Marshall in addition to pulsed-field pulmonary vein isolation reduces return of atrial fibrillation in adults with symptomatic paroxysmal AF undergoing their first ablation.

  Recruiting Beijing Anzhen Hospital · Beijing, Beijing Municipality · NCT07095959

• Cardiovascular risk in people with Crohn's disease and ulcerative colitis

  This study tests whether people with inflammatory bowel disease have different heart-attack or stroke risk over two years compared with matched controls.

  Recruiting IRCCS Policlinico S. Donato · San Donato Milanese, Milan · NCT07095634

• Comprehensive imaging of valve regurgitation and recurrence risk after atrial fibrillation ablation

  This project will use 3D transesophageal and transthoracic echocardiography to try to find imaging signs that predict valve regurgitation and which adults with atrial fibrillation planning ablation are more likely to have recurrence.

  Recruiting First Hospital of China Medical University · Shenyang, Liaoning · NCT07085650

• Daily AMBROSIA nutritional bar to prevent undernutrition and muscle loss in older adults with AF or heart failure

  This trial will try a daily AMBROSIA functional food plus nutritional counseling to see if it prevents undernutrition and muscle loss in people over 70 with atrial fibrillation or heart failure.

  Recruiting Azienda Ospedaliero-Universitaria Careggi · Florence · NCT07076329

• Substrate remodelling and targeted ablation for persistent atrial fibrillation

  This project will try using detailed 3D electrical mapping of the left atrium to guide targeted ablation (pulmonary vein reisolation, ganglionic plexi, and substrate ablation) for people with persistent atrial fibrillation undergoing their first catheter ablation.

  Recruiting Barts & The London NHS Trust · London · NCT07047235

• Comparing two pulsed-field ablation catheters for atrial fibrillation with left atrial appendage closure

  This will try two different pulsed-field ablation catheters in people with symptomatic, drug-refractory atrial fibrillation who also need left atrial appendage closure to see which is safer and more effective.

  Recruiting Hangzhou Dinova EP Technology Co., Ltd · Hangzhou · NCT07036965

• Catheter Ablation for Atrial Fibrillation and Ventricular Tachycardia: A Chinese Registry

  This registry follows adults with atrial fibrillation or ventricular tachycardia to see how well and safely catheter ablation works over time in real-world Chinese patients.

  Recruiting Beijing Anzhen Hospital · Beijing, Beijing Municipality and 1 other locations · NCT07024927

• Kardi Ai ECG telemetry monitoring for detecting heart rhythm problems

  The Kardi Ai wearable ECG system will be tested to see if it can accurately detect irregular heart rhythms in adults with or suspected of having heart rhythm disorders.

  Recruiting at 2 sites KARDI AI Technologies s.r.o. · Olomouc, Czechia and 1 other locations · NCT07018648

• Using a quick CT scan to check for left atrial clots before cardioversion in the Emergency Department

  This will test whether a rapid cardiac CT in the ED to look for left atrial clots lets people with symptomatic atrial fibrillation or flutter have safe same‑day cardioversion instead of being admitted or delayed.

  Recruiting at 3 sites Ottawa Heart Institute Research Corporation · Hershey, Pennsylvania and 2 other locations · NCT07002450

• Digital interventions to manage alcohol consumption and atrial fibrillation severity

  This study is testing whether using a special app and text messages to help people cut down or quit drinking alcohol can improve heart rhythm problems in those with atrial fibrillation.

  Recruiting University of California, San Francisco · San Francisco, California · NCT06995391

• Registry of adult patients with atrial fibrillation in China

  This study is creating a long-term registry of adults with atrial fibrillation in China to see how different treatments work and how they affect patients' lives.

  Recruiting at 2 sites Beijing Anzhen Hospital · Beijing, Beijing Municipality and 1 other locations · NCT06987825

• Cycle-length mapping with OPTRELL for non-paroxysmal atrial fibrillation

  This will try an ultra-high-density OPTRELL mapping catheter to map electrical cycle length and voltage in people with persistent or permanent atrial fibrillation to better target ablation.

  Recruiting Taipei Veterans General Hospital, Taiwan · Taipei, Outside US · NCT06960252

• Managing anticoagulants for patients needing high-risk surgery

  This study is testing a new way to manage blood-thinning medications for patients who need high-risk surgeries to see if it keeps them safer than the current method.

  Recruiting McMaster University · Hartford, Connecticut and 13 other locations · NCT06957366

• Music during catheter ablation for atrial fibrillation under light sedation

  This test will see if playing music during catheter ablation helps adults having their first atrial fibrillation procedure feel less anxious and in less pain while using light sedation.

  Recruiting Shaoxing People's Hospital · Shaoxing, Zhejiang · NCT06953752

• Understanding heart injury in patients with rapid atrial fibrillation

  This study is trying to see if people with rapid atrial fibrillation and heart injury are more likely to have blocked arteries compared to those without heart injury, using blood tests and heart imaging.

  Recruiting University of Edinburgh · Edinburgh, East of England · NCT06951100

• Assessing stroke risk in patients with newly diagnosed atrial fibrillation

  This study is testing how to identify stroke risk in people who have just been diagnosed with atrial fibrillation to see who might need blood-thinning medication to prevent strokes.

  Recruiting University of Southern Denmark · Esbjerg, Region Syddanmark · NCT06949319

• AI-guided ECG mapping plus pulmonary vein isolation for atrial fibrillation

  This trial tests whether adding the vMap® AI 12-lead ECG mapping system to standard pulmonary vein isolation helps adults with persistent or recurrent atrial fibrillation have better outcomes.

  Recruiting at 11 sites Vektor Medical · Jonesboro, Arkansas and 12 other locations · NCT06935591

• Catheter ablation for people with persistent atrial fibrillation and severe atrial functional mitral regurgitation

  This will test whether adding catheter ablation to usual medicines helps adults with persistent atrial fibrillation and moderate-to-severe or severe atrial functional mitral regurgitation reduce valve leakage and improve symptoms and outcomes.

  Recruiting at 12 sites Beijing Anzhen Hospital · Hefei, Anhui and 16 other locations · NCT06883864

• Stopping anticoagulants after successful atrial fibrillation ablation with intensive smartwatch monitoring

  This trial will test whether adults 18–80 who are 60–365 days after a successful AF ablation and have been on a NOAC can safely stop their blood thinner while using frequent smartwatch and patch monitoring, aiming to lower bleeding without raising stroke or embolism risk.

  Recruiting Beijing Anzhen Hospital · Hefei, Anhui and 21 other locations · NCT06871228

• Combining pulmonary vein isolation and left atrial appendage closure for atrial fibrillation treatment

  This study is testing if combining two procedures—one to isolate the pulmonary veins and another to close off a part of the heart—can help people with non-valvular atrial fibrillation who can't take blood thinners and are at high risk for stroke.

  Recruiting Asklepios proresearch · Hamburg, Free and Hanseatic City of Hamburg · NCT06861673

• AI-ECG alerts to catch early atrial fibrillation risk

  This trial tests whether an AI-powered ECG alert can help doctors find people at high risk of developing atrial fibrillation so they can be given continuous heart-rhythm monitoring.

  Recruiting National Defense Medical Center, Taiwan · Taipei · NCT06847932

• Virtual management of anticoagulant therapy for patients needing elective surgery

  This study is testing if virtual visits can safely manage blood thinner therapy for patients with atrial fibrillation who need elective surgery, instead of having them come in for in-person appointments.

  Recruiting at 10 sites McMaster University · Evanston, Illinois and 9 other locations · NCT06844227

• AI-driven 7-day single-lead ECG patch monitoring to detect new atrial fibrillation in older adults

  This project will test whether AI-read 7-day single-lead ECG patches can find new atrial fibrillation in people aged 60 and older in rural China better than routine 12-lead ECG screening.

  Recruiting Beijing Anzhen Hospital · Zhejiang, Quzhou · NCT06842147

• Exercise program for patients after atrial fibrillation ablation

  This study is testing whether a structured exercise program can help people who had atrial fibrillation ablation feel better and improve their heart health and quality of life.

  Recruiting Universidad de Zaragoza · Zaragoza, Zaragoza · NCT06832033

• Understanding Ischemic Stroke in Patients Taking Blood Thinners

  This study looks at how ischemic strokes affect people taking blood thinners for heart issues to see what helps prevent future strokes.

  Recruiting at 47 sites University of L'Aquila · Zagreb and 46 other locations · NCT06823466

• Pulsed-field ablation of the posterior left atrium and mitral isthmus for non-paroxysmal AF

  This tests the Varipulse pulsed-field ablation catheter for isolating pulmonary veins and treating the left atrial posterior wall and mitral isthmus in people with non-paroxysmal atrial fibrillation.

  Recruiting Charles University, Czech Republic · Prague · NCT06801392

• Reliability of Two-Stage Multiple-Repetition-Maximum Tests to Estimate 1-RM in People with Heart Disease and Risk Factors

  This study checks how well different formulas estimate the 1-RM from two submaximal tests in adults with heart disease or risk factors.

  Recruiting Technical University of Munich · München · NCT06796582

• Coherent Sine-Burst Electroporation (CSE) Ablation for Atrial Fibrillation

  This study will test whether the Argá Medtech CSE electroporation device can safely and effectively ablate heart tissue to treat adults with symptomatic paroxysmal or persistent atrial fibrillation who have not responded to drugs.

  Recruiting at 27 sites Arga Medtech SA · Birmingham, Alabama and 26 other locations · NCT06784466

• Integrated care for older patients with atrial fibrillation

  This study is testing a new team-based care approach for older patients with atrial fibrillation and other health issues to see if it helps them manage their condition better than regular care.

  Recruiting at 50 sites Heart Care Foundation · Haskovo and 49 other locations · NCT06775028

• Effects of Alcohol Consumption on Atrial Fibrillation Episodes

  This study is testing whether drinking small to moderate amounts of alcohol affects how often people with paroxysmal atrial fibrillation have episodes of irregular heartbeats.

  Recruiting at 2 sites University of California, San Francisco · San Francisco, California and 1 other locations · NCT06754176

• Identifying metabolic markers for preventing atrial fibrillation

  This study is trying to find specific metabolic markers in patients having heart surgery to see if they can help predict and prevent the return of atrial fibrillation.

  Recruiting University Hospital, Bordeaux · Pessac · NCT06735001

• Preventing POAF after heart surgery with posterior pericardiotomy

  This trial tests whether posterior pericardiotomy during cardiac surgery can reduce new atrial fibrillation after surgery in adults in China.

  Recruiting Changhai Hospital · Shanghai · NCT06728826

• Biodegradable amiodarone patches placed on the heart to prevent atrial fibrillation after open-heart surgery

  This trial will try placing biodegradable patches soaked with amiodarone on the outside of the atria during open-heart surgery to see if it reduces new atrial fibrillation after elective cardiac operations.

  Recruiting Phase 3 Jilin Heart Hospital · Changchun, Jinlin · NCT06722196

• Pacing and Ablation for Patients with Atrial Fibrillation

  This study is testing whether a combination of a special pacemaker and a procedure to block heart signals can help people with tough-to-treat atrial fibrillation feel better compared to just using medications.

  Recruiting Seoul National University Hospital · Seoul, Jongno-gu · NCT06699342

• Early versus later restart of blood thinners after surgery for chronic subdural hematoma in people with atrial fibrillation

  This trial will test whether restarting oral blood thinners 5 days versus 30 days after surgery is safer and better at preventing clots for adults with atrial fibrillation who had surgery for chronic subdural hematoma.

  Recruiting Helsinki University Central Hospital · Oulu, North Ostrobothnia and 5 other locations · NCT06696079

• Screening for Atrial Fibrillation after Stroke

  This study tests if checking for heart rhythm problems right after a stroke helps find more cases of atrial fibrillation compared to checking after leaving the hospital, and it also compares two different devices used for this screening.

  Recruiting Vestre Viken Hospital Trust · Sogneprest Munthe-kaas Vei 100, Gjettum · NCT06675383

• Pulsed field versus radiofrequency approaches to change vagal nerve effects during pulmonary vein isolation for paroxysmal AF

  This study tests whether pulsed field ablation, alone or combined with radiofrequency, changes vagal nerve activity during pulmonary vein isolation in people with paroxysmal atrial fibrillation.

  Recruiting VZW Cardiovascular Research Center Aalst · Aalst, Belgium · NCT06647485

• Home testing for sleep apnea to improve well-being in patients with atrial fibrillation

  This study is testing if home testing and treatment for sleep apnea can help people with atrial fibrillation feel better and improve their quality of life.

  Recruiting Herlev and Gentofte Hospital · Hellerup · NCT06618417

• Discontinuing blood thinners after successful catheter ablation for atrial fibrillation

  This study tests whether stopping anticoagulation after a successful AF ablation is safe for patients who have had no recurrence within a year.

  Recruiting at 4 sites Early Phase 1 China National Center for Cardiovascular Diseases · Boston, Massachusetts and 11 other locations · NCT06615596

• Comparing catheter ablation (cryo, radiofrequency, pulsed field) with medical therapy for people with atrial fibrillation and heart failure.

  This study will see if catheter ablation plus optimal heart-failure medicines helps people with atrial fibrillation and heart failure have fewer unplanned heart-failure hospital stays and lower risk of death than medicines alone.

  Recruiting at 24 sites University College, London · Halifax and 23 other locations · NCT06505798

• HeartWatch vs Holter: A Longer-Term Arm Monitors Heart Rhythm

  This study tests whether the HeartWatch arm monitor can match or improve on Holter monitoring for detecting rhythm problems in adults with suspected AF and other arrhythmias.

  Recruiting HelpWear Inc. · Calgary, Alberta · NCT06164808

• Using focal pulse ablation to treat atrial flutter and fibrillation

  This study is testing a new treatment using focal pulse ablation to see if it can help people with atrial flutter feel better and reduce their symptoms.

  Recruiting Hangzhou Dinova EP Technology Co., Ltd · Beijing, Beijing Municipality · NCT06157437

• Using P2Y12 inhibitors alone for patients with atrial fibrillation getting stents

  This study is testing if using just one type of blood thinner for a month, followed by a different one, is safer and just as effective for people with atrial fibrillation who are getting heart stents, compared to the usual combination of three blood thinners.

  Recruiting at 5 sites Phase 4 Insel Gruppe AG, University Hospital Bern · Hasselt and 14 other locations · NCT05955365

• Evaluating abelacimab for patients with atrial fibrillation unsuitable for oral anticoagulation

  This study is testing a new medication called abelacimab to see if it can help people with atrial fibrillation who can't take blood thinners avoid strokes.

  Recruiting at 645 sites Phase 3 Anthos Therapeutics, Inc. · Birmingham, Alabama and 788 other locations · NCT05712200

• Comparing LAA closure and anticoagulation for atrial fibrillation patients after brain bleeding

  This study is testing whether closing a part of the heart or using blood thinners is better for preventing strokes in patients with atrial fibrillation who have had a brain bleed.

  Recruiting at 29 sites Jena University Hospital · Mannheim, Baden-Wurttemberg and 38 other locations · NCT04298723

• Registry for patients with coronary artery disease and atrial fibrillation

  This study collects information from patients with coronary artery disease and atrial fibrillation to see how local care can improve their symptoms and quality of life.

  Recruiting Cardiovascular Innovation and Research Institute · Glenwood Springs, Colorado · NCT03428048

Related topics

Quick answers

How many Atrial Fibrillation (AF) clinical trials are recruiting right now?

137, as of November 12, 2026. 3 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 54 countries. The most sites are in China (30 trials), United States (24 trials), Germany (14 trials), Poland (13 trials), Spain (13 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 6, Phase 2: 5, Phase 4: 4, Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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