Comparing surgery and biologics for treating stricturing Crohn's disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to compare the effectiveness of surgical intervention versus biologic therapies in patients with stricturing Crohn's disease who have not responded to traditional medications. Participants will be assessed for intestinal obstructive symptoms and confirmed strictures, and will be randomly assigned to receive either surgery or biologics. The goal is to determine which treatment option provides better outcomes for managing symptoms and improving quality of life in these patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. with intestinal obstructive symptoms;
2. confirmed intestinal strictures;
3. traditional drugs failed to induce remission;
4. envidence of active bowel inflammation;
5. inappropriate for EBD;
6. acquirement of written informed consent of participant;

Exclusion Criteria:

1. unsuccessful medical treatment of intestinal obstruction;
2. complete obstruction;
3. contraindication for biologics;
4. penetrating disease;
5. short smaal bowel;
6. suspicion of bowel tumor;
7. no confirmed strictures;
8. comitant severe disese of other system;
9. obstructive symptoms under over 2 targets of biologics;
10. successful treatment with traditional drugs;
11. participate other clinical research.

Where it's running

• Department of General Surgery, Jinling hosptal,Medical School of Nanjing University
  Nanjing, Jiangsu, China Recruiting

Study contacts

• Study coordinator: Weinming Zhu, Ph.D.
• Email: juwiming@nju.edu.cn
• Phone: +86025-80860036

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.