Preventing POAF after heart surgery with posterior pericardiotomy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

PRINCE-CH is a multicenter randomized trial comparing posterior pericardiotomy to no posterior pericardiotomy in adults undergoing cardiac surgery in China. The primary outcome is the occurrence of postoperative atrial fibrillation, monitored with wearable ECG. The study aims to determine the safety and effectiveness of this surgical approach and its potential impact on recovery and resource use. Enrollment targets 650 participants across 15 centers, with continuous ECG monitoring during the postoperative period.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients older than or equal to 18 years of age
* Requiring surgical intervention on proximal aorta, cardiac valves, and/or coronary arteries
* Able to provide informed consent

Exclusion Criteria:

* History of atrial fibrillation or flutter
* Reoperations/minimally invasive cardiac surgery/emergent presentation
* Need for hypothermic circulatory arrest
* Disease of the left pleura or previous left thoracotomy
* Chest deformity
* Unlikely to participate in follow-up assessments

Where it's running

• Changhai Hospital
  Shanghai, China Recruiting

Study contacts

• Principal investigator: Hao Zhang, M.D. Ph.D. — Naval Medical University Changhai Hospital
• Study coordinator: Hao Zhang, M.D. Ph.D.
• Email: 13818178916@163.com
• Phone: 86-21-31161765

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.