Left atrial and appendage function after pulsed-field pulmonary vein isolation in paroxysmal AF

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, single-center observational study enrolling consecutive adults with symptomatic, drug-refractory paroxysmal AF undergoing first-time pulsed-field ablation for pulmonary vein isolation. Intracardiac echocardiography (ICE) will be used during the procedure to measure left atrial and left atrial appendage mechanical function before and immediately after PFA-PVI. The primary outcome is the acute change in LAA mechanical function, while secondary outcomes include changes in trans-mitral diastolic flow patterns, the incidence of new LAA functional stunning (≥20% reduction in LAA EF or a clinically significant drop in LAA emptying velocity), and the correlation with pre-procedural TTE measures of LA strain and LAVI. Results are intended to clarify whether a transient stunning effect exists and to inform peri-procedural anticoagulation management.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥18 years
* Paroxysmal AF in sinus rhythm at procedural onset

Exclusion Criteria:

* Persistent or long-standing AF
* Prior atrial ablation
* Significant valvular disease
* A history of LAA closure

Where it's running

• University Hospital Kralovske Vinohrady
  Prague, Czechia Recruiting

Study contacts

• Study coordinator: Marek Hozman, MD, PhD
• Email: marek.hozman@fnkv.cz
• Phone: +420267161111

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.