BDNF Levels and Atrial Cardiomyopathy in People Having AF Ablation
Official title: Association Between Circulating BDNF Levels and Atrial Cardiomyopathy in Patients Undergoing Ablation for Persistent Atrial Fibrillation
Run by Centre Hospitalier Universitaire Dijon · NCT07648329 · Data updated 2026-11-12
This study tests whether circulating BDNF levels are linked to atrial cardiomyopathy in adults having their first ablation for persistent atrial fibrillation.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 150 (estimated) |
| Sponsor | Centre Hospitalier Universitaire Dijon Academic / other |
| Locations | 1 site (Dijon) |
| Status | Recruiting |
| Started | October 20, 2026 |
| Main results expected | October 2029 |
| Study ends | October 2029 |
| Registry record updated | October 26, 2026 |
| Trial ID | NCT07648329 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18 years or older with persistent atrial fibrillation scheduled for a first ablation at Dijon Bourgogne University Hospital who can provide informed consent.
✕Probably not a fit
Patients who do not exhibit a link between BDNF levels and atrial cardiomyopathy may not derive a direct clinical benefit from the study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study explores the relationship between brain-derived neurotrophic factor (BDNF) levels in the blood and atrial cardiomyopathy among patients undergoing their first ablation for persistent atrial fibrillation. Participants will provide a blood sample and undergo a CT scan around their ablation procedure to help characterize their atrial tissue health. The goal is to see if BDNF correlates with markers of atrial disease that can complicate AF and its treatment. The study is conducted at Dijon University Hospital and involves adults who consent and meet the eligibility criteria. No intervention beyond standard care and the specified procedures is planned.
Why it matters
Potential benefit: If successful, the findings could improve understanding of the disease process and help identify biomarkers for atrial cardiomyopathy in AF patients undergoing ablation.
How similar studies have gone: Previous research has explored biomarkers in atrial disease, but this specific linkage between circulating BDNF and atrial cardiomyopathy in AF patients undergoing ablation is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Participants who have provided written consent * Patients aged 18 years or older. * Patients scheduled to undergo their first ablation procedure for persistent atrial fibrillation at the Dijon Bourgogne University Hospital Exclusion Criteria: * A person who is not enrolled in or eligible for a social security program * A person subject to a legal protective measure (guardianship, conservatorship) * Person subject to a judicial safeguard measure * Pregnant or breastfeeding woman * Adult who is legally incapacitated or unable to give consent * Ablation of paroxysmal AF with or without electroanatomical mapping
Where it's running
-
Chu Dijon Bourogne
Dijon, France Recruiting
Study contacts
- Study coordinator: Charles GUENANCIA
- Email: charles.guenancia@chu-dijon.fr
- Phone: 03.80.29.56.23
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Sex Differences in BDNF Response to a Maximal Exercise Test
This study tests whether men and women have different levels of BDNF in the blood after a maximal exercise test.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.