Sex-based differences in AF wiring and how they affect outcomes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

DISPARITY-AF is a prospective, single-center registry that looks at sex differences in the electrophysiological drivers of atrial fibrillation. In patients undergoing a first-time pulmonary vein isolation, the researchers will perform comprehensive mapping after ablation to identify steep repolarization gradients and extra-PV AF initiation sites. The goal is to see if women have a higher burden of unmapped triggers that could explain lower long-term success rates. Mapping uses approved systems and catheters that are routinely used at the center. Outcomes will be correlated with mapping findings to inform future ablation strategies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age between 18 and 80 years.
* Male or Female sex.
* Symptomatic paroxysmal or persistent AF indicated for a first-time catheter ablation.
* Ability to provide written informed consent.

Exclusion Criteria:

* Prior catheter ablation for AF or surgical MAZE.
* Long-standing persistent AF (\>12 months).
* Presence of intracardiac thrombus or contraindication to systemic anticoagulation.
* Pregnant women and patients not able to provide an informed consent

Where it's running

• Shamir Medical Center
  Be’er Ya‘aqov, Israel Recruiting

Study contacts

• Study coordinator: Anat Milman, MD
• Email: anatmi@shamir.gov.il
• Phone: +972-54-3166651

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Pulsed Field vs Cryoballoon for Pulmonary Vein Isolation in Atrial Fibrillation

  This trial tests whether pulsed field ablation can shorten the procedure for first-time PVI in AF patients compared with cryoballoon ablation, while keeping safety and effectiveness similar.

  Recruiting St. Josefs-Hospital Wiesbaden GmbH · Wiesbaden · NCT07910370

• Pulsed Field Ablation vs Cryoablation for Atrial Fibrillation Under Deep Sedation

  This trial tests whether pulsed field ablation (PFA) done under deep sedation works as well as cryoballoon ablation for treating atrial fibrillation, aiming to avoid general anesthesia.

  Recruiting East Sussex Healthcare NHS Trust · Eastbourne · NCT07900685

• Bachmann’s Bundle Pacing vs Right Atrial Appendage Pacing for AF

  This study tests two common atrial pacing methods to see which one is safer over 12 months for people getting a new pacemaker, ICD, or CRT device.

  Recruiting Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) · Pittsburgh, Pennsylvania · NCT07874763

• AI-powered ECG to help diagnose and predict outcomes in heart disease

  Researchers test an AI-enhanced ECG to help diagnose and predict outcomes for people with cardiovascular diseases.

  Recruiting Inha University Hospital · Incheon, Incheon · NCT07856472

• Pace-and-ablate strategy in atrial fibrillation: who benefits and long-term outcomes

  This study looks at adults with atrial fibrillation who underwent AV node ablation with permanent pacing to see who develops pacing-induced problems and how they do long-term.

  Recruiting at 5 sites Insel Gruppe AG, University Hospital Bern · Zabrze and 4 other locations · NCT07852221

• AI-based cardiac analysis using 12-lead and 1-lead ECG

  A clinician-facing pilot test to see if SmartECG-EF helps evaluate heart function using both 12-lead and single-lead ECGs in adults with heart conditions.

  Recruiting Inha University Hospital · Incheon, Incheon · NCT07844434

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.