Condition

Arrhythmia clinical trials and research

• 27Clinical trials
• 52NIH research projects
• 37Countries

Newest Arrhythmia clinical trials

All recruiting trials (27)

• Case-Based Collaborative Learning to Improve Arrhythmia Recognition for New ICU Nurses

  A randomized study tests whether case-based collaborative learning helps new ICU nurses recognize arrhythmias and feel safer about patient care.

  Recruiting Çanakkale Onsekiz Mart University · Istanbul, Kartal · NCT07780448

• AI-powered ECG tools to detect deadly heart rhythms and ICI-related myocarditis

  Researchers are testing AI-powered analysis of ECG data to see if it can help flag dangerous arrhythmias and myocarditis in people who may be affected by immune checkpoint inhibitors.

  Recruiting Groupe Hospitalier Pitie-Salpetriere · Paris · NCT07644715

• HeartBeam ECG Registry: See How Heartbeat Patterns Look Across People

  This registry tests HeartBeam ECG recordings in real-world patients to build a de-identified database for research.

  Recruiting HeartBeam, Inc. · Pittsburgh, Pennsylvania · NCT07501299

• RHYthm and Myocardial Function Relationship in Heart Disease

  This study tests how heart rhythm patterns relate to heart muscle function in adults with arrhythmias or cardiomyopathy.

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Roma · NCT07491237

• Start CPAP After AF Ablation in OSA Patients

  This study tests whether adding CPAP after AF ablation helps prevent atrial arrhythmia recurrence in adults with obstructive sleep apnea.

  Recruiting at 3 sites Beijing Anzhen Hospital · Beijing, Beijing Municipality and 29 other locations · NCT07444372

• Cardiac rehabilitation cohort at Medicine Campus Davos to explore recovery

  This project will follow adults coming to Hochgebirgsklinik Davos for cardiac rehabilitation to see how their heart health and recovery progress over time.

  Recruiting Hochgebirgsklinik Davos · Davos, Kanton Graubünden · NCT07096973

• Using BIOMONITOR IV to track heart rhythm and warning signs in people with heart failure

  This project will test whether a small implanted monitor called BIOMONITOR IV can track irregular heartbeats and body signals in people with heart failure who do not have ICD/CRT devices to see if it can warn doctors before the heart failure gets worse.

  Recruiting Biotronik SE & Co. KG · Genk and 1 other locations · NCT06989580

• Evaluating safety and effectiveness of radiofrequency ablation after left atrial appendage closure

  This study is testing if a heart procedure called radiofrequency ablation is safe and effective for people with atrial fibrillation after they have had a device placed to close off a part of their heart to reduce stroke risk.

  Recruiting Affiliated Hospital of Nantong University · Nantong, Jiangsu · NCT06984731

• Understanding the connection between stroke and heart issues

  This study is trying to understand how strokes affect heart health and overall well-being in stroke patients to find new ways to help them recover better.

  Recruiting Tongji Hospital · Wuhan, Hubei · NCT06954103

• Understanding the genetics of arrhythmia-induced cardiomyopathy

  This study is trying to see if certain genetic traits in people with arrhythmia-induced cardiomyopathy can help predict their heart health and outcomes after treatment.

  Recruiting at 2 sites Hospital Universitario 12 de Octubre · Ciudad Real, Castille-La Mancha and 3 other locations · NCT06896266

• Children's quality of life before and after catheter ablation for arrhythmia

  This will see if catheter ablation improves quality of life in children aged 8–17 who need the procedure for arrhythmia.

  Recruiting at 4 sites Hospices Civils de Lyon · Bron and 6 other locations · NCT06808204

• New point-of-care dry electrolyte analyzer for emergency patients

  This project will test whether a new point-of-care dry electrolyte analyzer (P1) gives results similar to the standard Nova system for people getting electrolyte tests in the emergency department.

  Recruiting Zhujiang Hospital · Guangzhou, Guangdong · NCT06726460

• Evaluating endomyocardial biopsy and tailored treatments for pediatric inflammatory heart disease

  This study is testing how a heart tissue sample and personalized treatments can help kids with inflammatory heart disease, especially those with myocarditis and heart rhythm issues.

  Recruiting Scientific Institute San Raffaele · Milan, Milano · NCT06591260

• AI-powered ECG to detect heart disease and atrial fibrillation in routine care

  This trial tests whether an AI-based ECG tool can help doctors find undiagnosed heart disease and atrial fibrillation in patients and whether using the tool changes clinical decisions and outcomes.

  Recruiting Northwestern University · Chicago, Illinois · NCT06511505

• Ablation of focal activation in atrial fibrillation

  This study is testing a new method to find specific electrical signals that may be causing ongoing atrial fibrillation in patients, to see if targeting these signals can improve their treatment.

  Recruiting Imperial College London · London · NCT06402617

• Monitoring heart rhythms in patients with suspected arrhythmia

  This study is testing whether continuous ECG patches work better than handheld ECG devices for diagnosing arrhythmia symptoms in patients who haven't gotten clear results from standard tests.

  Recruiting at 4 sites Wonju Severance Christian Hospital · Gwangju, Dong-gu Jaebongro 42 and 3 other locations · NCT06250712

• Evaluating the Aveir Atrial Leadless Pacemaker for Medicare Patients

  This study is testing how well the Aveir Atrial Leadless Pacemaker works and what complications it might cause for Medicare patients compared to a regular pacemaker.

  Recruiting Abbott Medical Devices · Sylmar, California · NCT06100770

• Registry for patients with anomalous aortic origin of coronary arteries

  This study is collecting information from patients with a rare heart condition called anomalous aortic origin of coronary arteries to see how different treatments work and improve care for everyone.

  Recruiting at 2 sites University of Padova · Padova, PD and 1 other locations · NCT06089902

• Evaluating inflammation changes in patients after heart rhythm procedure

  This study looks at how inflammation and fat levels change in people aged 18 to 85 after they have a heart procedure to treat atrial fibrillation.

  Recruiting Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico · Milan · NCT05961865

• Effects of lung cancer surgery on heart function and electrocardiograms

  This study is testing how modern lung cancer surgery affects heart function and heart rhythms in adults to see what changes happen during and after the surgery.

  Recruiting Tampere University Hospital · Tampere, Pirkanmaa · NCT05094843

• Using a device to prevent strokes during heart procedures for atrial fibrillation

  This study tests whether a special device can help prevent strokes during heart procedures for people with atrial fibrillation and see if it improves their thinking skills afterward.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT04685317

• Evaluating endomyocardial biopsy and tailored treatments for inflammatory heart disease

  This study is trying to see if a heart tissue test and personalized treatments can help people with inflammatory heart disease, especially those with myocarditis and heart rhythm issues.

  Recruiting Scientific Institute San Raffaele · Milan, Milano · NCT04521790

• Registry for patients referred to cardio-oncology

  This study is collecting information from cancer patients who are referred for heart health checks to see how cancer treatments might affect their hearts.

  Recruiting European Georges Pompidou Hospital · Paris · NCT04407780

• Registry for outcomes of implantable cardioverter-defibrillators in outpatient settings

  This study looks at the safety and costs of getting implantable cardioverter-defibrillators in outpatient centers to see how well the process works for patients and doctors.

  Recruiting QuesGen Systems Inc · Lehi, Utah · NCT03604133

• Observational study on heart defibrillators for preventing sudden cardiac death

  This study looks at patients with heart defibrillators to see what factors might increase the risk of sudden cardiac death and how to better choose who needs these devices.

  Recruiting at 4 sites Johns Hopkins University · Washington D.C., District of Columbia and 3 other locations · NCT00733590

• Evaluating long-term performance of Medtronic cardiac devices

  This study is testing how well Medtronic heart devices, like pacemakers and defibrillators, work over the long term for people who have recently received or are about to receive one of these implants.

  Recruiting at 223 sites Medtronic · Birmingham, Alabama and 337 other locations · NCT00271180

• Exploring the genetics behind heart and muscle diseases

  This study is trying to find out how genetics play a role in heart and muscle diseases by looking at blood samples from families with these conditions.

  Recruiting University of Chicago · Chicago, Illinois · NCT00138931

NIH-funded research (newest 40 of 52)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Understanding how heart nerves affect dangerous heart rhythms after a heart attack

  This NIH grant studies how changes in the heart’s nerve signaling after a heart attack lead to dangerous rhythm problems, with the goal of finding ways to prevent them.

  NIH research University of California-Irvine · Irvine, United States · NIH-11565444

• Dexterous needle ablation for ventricular arrhythmia guided by MRI

  A new MRI-guided, robot-assisted catheter delivers deeper heart tissue ablation to treat ventricular tachycardia.

  NIH research Georgia Institute of Technology · Atlanta, United States · NIH-11450570

• Sex-specific heart cell signaling and rhythm problems linked to a heart failure drug target

  A study from UCLA aims to understand how a key heart signaling pathway controls heart beating and rhythm differently in men and women with heart failure.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11412596

• Additive-made wearable magnetic sensors for heart monitoring with AI

  A wearable system using affordable, 3D-printed sensors and machine learning to help detect heart rhythm problems in people.

  NIH research Texas Tech University · Lubbock, United States · NIH-11397238

• Understanding fat deposits after heart attack and their link to dangerous heart rhythms

  A Penn Medicine team is studying how fat buildup in the heart after a heart attack may influence dangerous heart rhythms and recovery.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11393352

• Developing 3D Real-Time CMR for Arrhythmia Imaging

  Aims to make real-time 3D heart MRI usable for people with irregular heartbeats to improve how doctors see arrhythmias.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11391749

• Precision imaging of heart rhythms to map arrhythmias without surgery

  A new 3D ultrasound method could noninvasively map how abnormal heart rhythms start and travel, helping doctors plan safer treatments for people with arrhythmias.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11385556

• New roles for a heart protein in preventing dangerous rhythms

  A heart study will explore how a specific protein regulator (PP2A) affects ion channels that control heartbeat, with the goal of reducing dangerous arrhythmias.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11375997

• Population-based computer approach to predict arrhythmias and guide therapy

  A population-based computer approach is being developed to predict dangerous heart rhythms and guide drug or device therapy for people at risk of sudden cardiac death.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11375176

• Real-Time AI-Driven Autonomic Neuromodulation to Prevent Ventricular Arrhythmias After Heart Attack

  A new AI-guided system aims to adaptively modulate the autonomic nervous system in real time to prevent dangerous heart rhythm problems in people with a prior heart attack.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11340665

• Role of a neutrophil protein in preventing heart rhythm problems after a heart attack

  A heart-attack-related study looks at whether a neutrophil protein called RELMγ could prevent dangerous heart rhythms and help guide new treatments.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11339672

• N-terminal acetylation and heart disease in people with autism spectrum traits

  This grant looks at how a specific protein modification may contribute to heart problems in people with autism, aiming to uncover targets that could reduce dangerous heart rhythms.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11330165

• How aging, a heart calcium channel (TRPV4), and angiotensin II can cause dangerous heart rhythms

  This research is seeing whether blocking a heart calcium channel called TRPV4 can reduce angiotensin II–related dangerous ventricular rhythms in aging hearts.

  NIH research University of Missouri-Columbia · Columbia, United States · NIH-11309556

• Non-selective large conductance ion channels and triggered arrhythmia in hearts

  A study at Vanderbilt seeks to understand how certain ion channels in heart cells may trigger dangerous heart rhythms, with the goal of improving prevention and treatment for people at risk.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11308283

• Noninvasive electromechanical imaging to map abnormal heart rhythms

  This project tries an ultrasound-based imaging technique to find where abnormal heartbeats start in people with atrial fibrillation and other arrhythmias.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11308254

• MRI-guided robotic catheter to improve treatment for atrial fibrillation

  This project builds an MRI-compatible robotic catheter and real-time feedback system to help doctors create more complete, lasting ablation lesions for people with atrial fibrillation.

  NIH research Georgia Institute of Technology · Atlanta, United States · NIH-11307065

• Understanding how small potassium channels affect heart rhythm and disease

  Aims to understand how tiny calcium-activated potassium channels influence heart rhythm and potentially lead to new treatments for atrial fibrillation and heart failure.

  NIH research University of Arizona · Tucson, United States · NIH-11294983

• Tiny separations at heart cell connections that may cause arrhythmias

  This project looks at whether tiny separations between heart cells make dangerous heart rhythms more likely in people with Brugada syndrome or arrhythmogenic cardiomyopathy.

  NIH research Virginia Polytechnic Inst and St Univ · Blacksburg, United States · NIH-11293399

• How heart-cell lysosomes might cause dangerous heart rhythms

  Researchers are looking at whether tiny cell compartments called lysosomes in heart cells cause dangerous abnormal heart rhythms in people with cardiomyopathy.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11258018

• 3D ultrasound mapping to locate sources of abnormal heart rhythms

  This project uses a fast, radiation-free 3D ultrasound method to find where irregular heartbeats start in adults with arrhythmias.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11193775

• Post–heart attack fat in the heart and risky heart rhythms

  This project looks at whether fat that forms inside the heart after a heart attack is linked to dangerous ventricular rhythms in people who have had a myocardial infarction.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11159658

• Using computers to better predict and treat heart rhythm problems

  This project uses advanced computer modeling to understand and predict dangerous heart rhythms, like those that cause sudden cardiac death, aiming to find safer and more effective treatments for patients.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11135498

• Understanding a New Way to Control Heart Rhythm Problems

  This work explores how a specific protein in the heart helps regulate electrical signals, aiming to find new ways to prevent dangerous heart rhythm issues.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11128719

• Understanding Heart Rhythm Patterns and Substance Use in Young People

  This project looks at how heart rhythm patterns in young adolescents might help us understand who is more likely to use substances, so we can offer support early.

  NIH research Rhode Island Hospital · Providence, United States · NIH-11121900

• Wearable magnetic heart sensors for better rhythm monitoring

  This project will create low-cost, chest-worn magnetic sensors plus smart computer programs to help spot abnormal heart rhythms in people.

  NIH research Texas Tech University · Lubbock, United States · NIH-11095607

• Improving heart rhythm treatment using advanced robotic technology and imaging.

  This study is working on a new robotic system that uses MRI to help doctors treat atrial fibrillation more effectively during heart procedures, aiming to make the treatments more successful and reduce the chances of the condition coming back.

  NIH research Georgia Institute of Technology · Atlanta, United States · NIH-11083144

• Understanding how N-terminal acetylation affects heart function and arrhythmias

  This study is looking at how certain genetic changes affect heart function in people with dilated cardiomyopathy and arrhythmias, using special cells from patients to better understand these conditions and find new ways to help treat them.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11083117

• Understanding how lysosomes affect heart rhythm

  This study is looking at how tiny parts of your cells called lysosomes might affect heart rhythms in people with cardiomyopathy, helping us understand why some people experience irregular heartbeats and how we can improve heart health.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11071049

• Exploring the mechanisms behind heart rhythm disorders

  This conference is all about helping doctors and researchers understand what causes irregular heartbeats, so they can find better ways to diagnose and treat these issues for people at risk of serious health problems like strokes or sudden heart failure.

  NIH research Gordon Research Conferences · East Greenwich, UNITED STATES · NIH-11065758

• AI and 4D ultrasound to pinpoint where abnormal heart rhythms begin

  Uses AI together with time-resolved 3D (4D) ultrasound to find where abnormal heart rhythms start in people with arrhythmias.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11062814

• Examining how aging affects heart rhythm differences between men and women

  This study is looking at how getting older affects the risk of developing atrial fibrillation, a common heart rhythm issue, and whether there are differences between men and women, to help us understand why older adults, especially women, might be more likely to experience this condition.

  NIH research University of California at Davis · Davis, United States · NIH-11057951

• Investigating how large ion channels contribute to heart rhythm problems

  This study is looking at how too much calcium in heart cells can cause dangerous heart rhythms, and it's for anyone interested in understanding how we might prevent sudden heart problems.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11056861

• Understanding heart rhythm problems linked to specific proteins in heart cells

  This study is looking at how specific genetic changes can cause heart rhythm problems like Brugada Syndrome and Arrhythmogenic Cardiomyopathy, and it aims to find new ways to help people with these conditions feel better and stay safe.

  NIH research Virginia Polytechnic Inst and St Univ · Blacksburg, United States · NIH-11045714

• Improving treatments for heart rhythm disorders

  This study is looking into how irregular heartbeats happen and aims to find better treatments for people with these heart issues, so they can feel safer and healthier.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11031410

• Therapeutic development of RyR2-inhibiting flecainide analogs for arrhythmia prevention

  A Vanderbilt-led project aims to develop flecainide-like drugs that specifically calm the RyR2 channel to prevent dangerous heart rhythms in adults.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11028804

• Investigating how genetics can help predict arrhythmia risk

  This study is looking at how our genes might play a role in heart rhythm problems and sudden cardiac death, so we can better understand who might be at risk and help keep people safe.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11010773

• Understanding heart rhythms to improve treatment for arrhythmias

  This study is working on a new way to understand heart rhythm problems in people with heart muscle disease by looking at how the heart is structured and how it works electrically, so doctors can better assess risks and personalize treatments for patients.

  NIH research Stanford University · Stanford, United States · NIH-11005712

• Investigating a new approach to treat heart issues in boys with Duchenne muscular dystrophy.

  This study is looking at how a protein called Pannexin 1 affects heart issues in kids with Duchenne muscular dystrophy (DMD), and it hopes to find ways to improve heart health and reduce heart problems for these children.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-10992595

• Understanding how potassium channels fold and assemble to prevent heart rhythm problems

  This study is looking at how potassium channels in heart cells work and how certain genetic changes can cause heart rhythm problems like Long-QT and Brugada syndromes, with the goal of finding better ways to treat or prevent these issues for patients.

  NIH research University of Chicago · Chicago, United States · NIH-10989955

• Investigating the link between heart tissue changes after a heart attack and dangerous heart rhythms.

  This study is looking at how fat buildup in the heart after a heart attack can affect heart rhythms, and it's for patients who have had a heart attack to help understand their heart health better.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-10981906

Related topics

Quick answers

How many Arrhythmia clinical trials are recruiting right now?

27, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 37 countries. The most sites are in United States (7 trials), Italy (6 trials), China (5 trials), France (4 trials), Switzerland (3 trials). Each study page lists its sites and which ones are recruiting.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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