Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Optimal shock energy for electrical cardioversion of atrial fibrillation

Official title: Optimal Initial Shock Energy for Elective Direct Current Biphasic Electrical Cardioversion of Atrial Fibrillation

Run by Motol and Homolka University Hospital · NCT07610980 · Data updated 2026-11-12

This study tests whether starting with a higher initial shock energy for electrical cardioversion helps restore normal rhythm in people with atrial fibrillation.

More Atrial Fibrillation (AF) trials

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment400 (estimated)
SponsorMotol and Homolka University Hospital
Academic / other
Locations1 site (Prague)
StatusRecruiting
StartedMay 18, 2026
Main results expectedDecember 2028
Study endsJune 2029
Registry record updatedOctober 13, 2026
Trial IDNCT07610980 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults with atrial fibrillation or atypical atrial flutter who require elective electrical cardioversion and are deemed eligible by an independent physician.

Probably not a fit

Patients with typical atrial flutter or focal atrial tachycardia, or those not meeting eligibility criteria, may not benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The trial investigates the best initial biphasic direct current shock energy for elective electrical cardioversion in atrial fibrillation. It builds on prior data suggesting that a higher initial energy (360 J) may be more effective and reduce the need for multiple shocks, while monitoring safety. Direct current cardioversion procedures will include blood sampling to assess safety markers. Participants are adults with atrial fibrillation or atypical atrial flutter deemed eligible by their physicians. The trial is conducted at Motol and Homolka University Hospitals in Prague.

Why it matters

Potential benefit: If successful, patients may experience a higher chance of successful rhythm restoration with fewer shocks.

How similar studies have gone: Prior randomized data suggested higher initial energy can be more effective and may reduce total shock energy without signs of myocardial injury.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Atrial fibrillation
* Atypical atrial flutter
* Indication for elective electrical cardiac version made by independent physician

Exclusion Criteria:

* Typical atrial flutter
* Focal atrial tachycardia

Where it's running

  • Motol and Homolka University Hospital, Homolka site
    Prague, Czechia
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.