Optimal shock energy for electrical cardioversion of atrial fibrillation
Official title: Optimal Initial Shock Energy for Elective Direct Current Biphasic Electrical Cardioversion of Atrial Fibrillation
Run by Motol and Homolka University Hospital · NCT07610980 · Data updated 2026-11-12
This study tests whether starting with a higher initial shock energy for electrical cardioversion helps restore normal rhythm in people with atrial fibrillation.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 400 (estimated) |
| Sponsor | Motol and Homolka University Hospital Academic / other |
| Locations | 1 site (Prague) |
| Status | Recruiting |
| Started | May 18, 2026 |
| Main results expected | December 2028 |
| Study ends | June 2029 |
| Registry record updated | October 13, 2026 |
| Trial ID | NCT07610980 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with atrial fibrillation or atypical atrial flutter who require elective electrical cardioversion and are deemed eligible by an independent physician.
✕Probably not a fit
Patients with typical atrial flutter or focal atrial tachycardia, or those not meeting eligibility criteria, may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The trial investigates the best initial biphasic direct current shock energy for elective electrical cardioversion in atrial fibrillation. It builds on prior data suggesting that a higher initial energy (360 J) may be more effective and reduce the need for multiple shocks, while monitoring safety. Direct current cardioversion procedures will include blood sampling to assess safety markers. Participants are adults with atrial fibrillation or atypical atrial flutter deemed eligible by their physicians. The trial is conducted at Motol and Homolka University Hospitals in Prague.
Why it matters
Potential benefit: If successful, patients may experience a higher chance of successful rhythm restoration with fewer shocks.
How similar studies have gone: Prior randomized data suggested higher initial energy can be more effective and may reduce total shock energy without signs of myocardial injury.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Atrial fibrillation * Atypical atrial flutter * Indication for elective electrical cardiac version made by independent physician Exclusion Criteria: * Typical atrial flutter * Focal atrial tachycardia
Where it's running
-
Motol and Homolka University Hospital, Homolka site
Prague, Czechia Recruiting
Study contacts
- Study coordinator: Jan Naar, MD, PhD
- Email: jan.naar@fnmh.cz
- Phone: +420257272208
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Pulsed Field vs Cryoballoon for Pulmonary Vein Isolation in Atrial Fibrillation
This trial tests whether pulsed field ablation can shorten the procedure for first-time PVI in AF patients compared with cryoballoon ablation, while keeping safety and effectiveness similar.
-
Pulsed Field Ablation vs Cryoablation for Atrial Fibrillation Under Deep Sedation
This trial tests whether pulsed field ablation (PFA) done under deep sedation works as well as cryoballoon ablation for treating atrial fibrillation, aiming to avoid general anesthesia.
-
Bachmann’s Bundle Pacing vs Right Atrial Appendage Pacing for AF
This study tests two common atrial pacing methods to see which one is safer over 12 months for people getting a new pacemaker, ICD, or CRT device.
-
AI-powered ECG to help diagnose and predict outcomes in heart disease
Researchers test an AI-enhanced ECG to help diagnose and predict outcomes for people with cardiovascular diseases.
-
Pace-and-ablate strategy in atrial fibrillation: who benefits and long-term outcomes
This study looks at adults with atrial fibrillation who underwent AV node ablation with permanent pacing to see who develops pacing-induced problems and how they do long-term.
-
AI-based cardiac analysis using 12-lead and 1-lead ECG
A clinician-facing pilot test to see if SmartECG-EF helps evaluate heart function using both 12-lead and single-lead ECGs in adults with heart conditions.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.