Pulsed Field Ablation Outcomes in Atrial Fibrillation: Randomized Comparison to Traditional Ablation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional trial compares pulsed field ablation (PFA) with radiofrequency ablation (RFA) for treating atrial fibrillation in adults. Participants undergo either PFA or RFA to determine safety and effectiveness in maintaining sinus rhythm. The study utilizes predefined criteria to enroll eligible patients and excludes those with recent cardiac events or contraindications to ablation. Outcomes will inform whether the novel PFA approach offers advantages over traditional energy delivery. The trial is conducted under the banner of the China National Center for Cardiovascular Diseases at Fuwai Hospital.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Atrial fibrillation patients who will accept catheter ablation.
2. Age ≥ 18.
3. Be capable of understanding and signing the informed consent form.

Exclusion Criteria:

1. Have contraindications for catheter ablation (such as atrial thrombosis, decompensated heart failure, etc.)
2. Have accepted catheter ablation before.
3. Myocardial infarction, or any cardiac interventional/surgery has been performed within 3 months.
4. Had a stroke or transient ischemic attack within 6 months.
5. Allergy to iodine contrast agents.
6. Participate in clinical trials related to other drugs or devices.
7. Pregnant women, lactating women, or women with plans to become pregnant shortly.
8. Active stage of infection.
9. Secondary atrial fibrillation, such as combined with rheumatic heart disease, hypertrophic cardiomyopathy, etc.
10. Patients who do not agree to be enrolled or are unable to cooperate to complete the study

Where it's running

• National Cardiovascular Diseases Center, Fuwai Hospital
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Study coordinator: Yan Yao
• Email: ianyao@263.net.cn
• Phone: 010-88392405

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Electroporation versus Radiofrequency Ablation Guided by 3D Imaging for Repeat Atrial Fibrillation

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• Factors Linked to Slow Heart Rate After Pulsed Field Ablation for Atrial Fibrillation

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• Very high-power short-duration vs standard low-power radiofrequency ablation for atrial fibrillation

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• BDNF Levels and Atrial Cardiomyopathy in People Having AF Ablation

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• Catheter ablation vs optimized medical care for very elderly with atrial fibrillation

  In people aged 78 and up with AF, this study tests whether catheter ablation can help by comparing it to tailored medical therapy, using a wearable rhythm monitor to track AF over time.

  Recruiting Karolinska University Hospital · Linköping and 1 other locations · NCT07424690

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.