Electroporation versus Radiofrequency Ablation Guided by 3D Imaging for Repeat Atrial Fibrillation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective randomized trial assigns patients with recurrent AF who need repeat pulmonary vein isolation to receive either non-thermal pulsed field electroporation or standard radiofrequency ablation, both performed with 3D electroanatomical mapping. Procedures follow routine hospital protocols and require no additional invasive tests beyond the re-ablation. Participants return for clinical review, 12-lead ECG and 24-hour Holter monitoring at 3, 6, and 12 months, with unscheduled ECGs available if symptoms recur. The study compares procedural safety, arrhythmia recurrence, and need for further interventions between the two approaches.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Documented recurrence of AF or atypical atrial flutter after prior PVI Eligibility for re-PVI

Exclusion Criteria:

Left ventricular ejection fraction \< 30% Left atrial volume index (LAVI) \> 72 mL/m² Untreated hyperthyroidism Hypertrophic cardiomyopathy Severe valvular heart disease

Where it's running

• Clinical Department of Cardio, Jan Mikulicz Radecki University Hospital in Wroclaw
  Wroclaw, Poland Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Pulsed field ablation registry for atrial arrhythmias in Poland.

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• Factors Linked to Slow Heart Rate After Pulsed Field Ablation for Atrial Fibrillation

  This study looks for factors that might cause bradycardia during the hospital stay after AF ablation using pulsed field technology.

  Recruiting Wroclaw Medical University · Wroclaw, Lower Silesian Voivodeship · NCT07809347

• Concomitant Pulsed Field Ablation and Left Atrial Appendage Closure in AF Patients

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• Comparing FARAPULSE and FARAWAVE Nav catheters during pulmonary vein isolation for atrial fibrillation

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  Recruiting Cardiocentro Ticino · Lugano, Canton Ticino · NCT07130773

• Pulsed Field vs Cryoballoon for Pulmonary Vein Isolation in Atrial Fibrillation

  This trial tests whether pulsed field ablation can shorten the procedure for first-time PVI in AF patients compared with cryoballoon ablation, while keeping safety and effectiveness similar.

  Recruiting St. Josefs-Hospital Wiesbaden GmbH · Wiesbaden · NCT07910370

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.