Extended ablation added to PVI for persistent atrial fibrillation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter randomized trial compares two ablation strategies in patients with symptomatic persistent AF who are planned for a first ablation. One group receives standard pulmonary vein isolation alone, while the other group receives PVI plus additional linear lesions using a PF/RF ablation system. The primary endpoint is time to first recurrence of AF, atrial tachycardia, or atrial flutter within 12 months. The trial uses contemporary energy delivery capable of combining pulsed-field and radiofrequency ablation. Eligible participants have persistent AF (not long-standing), with several safety and health criteria guiding inclusion and exclusion.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* symptomatic persistent AF
* ≥1 episode of persistent AF in the last 12 months
* signed informed consent

Exclusion Criteria:

* first-manifested AF, paroxysmal AF, long-standing persistent AF, permanent AF
* SR on admission without Class I/III AADs
* AF of secondary cause (e.g. hyperthyroidism)
* any previous LA ablation
* severe valvular disease (mitral valve insufficiency ≥3+, moderate or severe aortic stenosis) or history of valvular surgery or intervention
* left ventricular ejection fraction ≤40%
* pulmonary hypertension (estimated systolic pulmonary artery pressure ≥40 mm Hg)
* symptomatic coronary artery disease
* pregnancy
* LA anteroposterior diameter ≥55 mm
* body mass index ≥40 kg/m2
* age ≥80 years
* chronic kidney disease stage 3b or higher
* contraindication to anticoagulation
* general contraindications of catheter ablation
* life expectancy \<2 years due to other comorbidities

Where it's running

• University Hospital Olomouc
  Olomouc, Czechia Recruiting
• Ikem
  Prague, Czechia Recruiting
• Cardiocenter, 3rd Medical School, Charles University and University Hospital Kralovske Vinohrady
  Prague, Czechia Recruiting
• University Hospital Kralovske Vinohrady
  Prague, Czechia Recruiting

Study contacts

• Study coordinator: Pavel Osmancik
• Email: pavel.osmancik@gmail.com
• Phone: 00420-267163029

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.