Understanding heart injury in patients with rapid atrial fibrillation
Mechanisms of Myocardial Injury and Ischemia in Patients With Rapid Atrial Fibrillation
This study is trying to see if people with rapid atrial fibrillation and heart injury are more likely to have blocked arteries compared to those without heart injury, using blood tests and heart imaging.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 300 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Edinburgh Academic / other |
| Locations | 1 site (Edinburgh, East of England) |
| Trial ID | NCT06951100 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the relationship between rapid atrial fibrillation (AF) and myocardial injury, focusing on the role of troponin levels and coronary imaging. It seeks to determine if patients with rapid AF and heart damage are more likely to have obstructive coronary artery disease compared to those without heart damage. Additionally, the study will assess whether these patients show signs of myocardial ischemia and infarction through various heart imaging techniques. Participants will undergo blood tests and advanced imaging, including electrocardiograms, echocardiograms, CT scans, and cardiac MRIs.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 and over presenting with symptoms of rapid atrial fibrillation and a ventricular rate greater than 100 bpm.
Not a fit: Patients with a history of myocardial infarction, coronary revascularization, or significant renal failure may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic strategies for patients with rapid atrial fibrillation and associated heart injuries.
How similar studies have performed: Other studies have explored similar relationships between atrial fibrillation and myocardial injury, suggesting potential for meaningful insights, though this specific approach may be novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age 18 years and over 2. Primary presentation with symptoms related to atrial fibrillation 3. Atrial fibrillation with a ventricular rate \>100 bpm on a 12-lead electrocardiogram 4. Able to provide informed consent Exclusion Criteria 1. Previous myocardial infarction 2. Previous coronary revascularisation procedure 3. Patients in renal failure (eGFR \<30ml/min/1.73m2) or major allergy to contrast media 4. Pregnancy or breast feeding 5. Deemed unsuitable for participation in the study by the attending clinician 6. Previous enrolment in the trial
Where this trial is running
Edinburgh, East of England
- Royal Infirmary of Edinburgh — Edinburgh, East of England, United Kingdom (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.