Personalized Atrial Fibrillation Ablation Using Unipolar QS-Potential Mapping

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study enrolls adults with atrial fibrillation undergoing catheter ablation and compares personalized ablation guided by unipolar QS-potential mapping to conventional pulmonary vein isolation. The approach seeks to better detect electrical signals across heart layers by focusing on QS potentials, potentially identifying breakthrough sites between the epicardium and endocardium. Participants receive either the QS-potential guided ablation or standard ablation, with follow-up planned at 3 months post-procedure. The trial is led by the China National Center for Cardiovascular Diseases at Fuwai Hospital in Beijing and includes adults up to 80 years old, including those with recurrent AF after prior ablation. Key eligibility requires planned AF ablation, the ability to consent, and adherence to follow-up, while exclusions include reduced heart function, severe valve disease, intracardiac thrombus, contraindications to anticoagulation, infection, pregnancy, limited life expectancy, or recent interventional trial participation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18 years and ≤ 80 years
* Documented diagnosis of atrial fibrillation (paroxysmal or persistent)
* Planned to undergo catheter ablation for AF (including patients with recurrent AF after prior ablation)
* Able and willing to provide written informed consent
* Able to complete scheduled follow-up visits (3 months post-ablation)

Exclusion Criteria:

* Left ventricular ejection fraction \< 35%
* Severe valvular heart disease (moderate to severe mitral stenosis or regurgitation)
* History of intracardiac thrombus
* Contraindication to anticoagulation
* Active infection or sepsis
* Pregnancy or breastfeeding
* Life expectancy \< 12 months due to comorbid conditions
* Participation in another interventional clinical trial within 30 days prior to enrollment

Where it's running

• Fuwai Hospital
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Study coordinator: Aiju Tian
• Email: taj2015@163.com
• Phone: +8618811592092

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.