Finerenone after catheter ablation to see if it reduces AF recurrence

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a single-center, randomized, investigator-blinded Phase II pilot trial enrolling about 40 adults undergoing their first radiofrequency or pulsed field AF ablation. After successful pulmonary vein isolation, participants are randomized to finerenone or usual care for 12 months, with rhythm monitoring and follow-up visits at 2 weeks, 1, 3, 6, 9, and 12 months. The study also uses cardiac CT to characterize epicardial adipose tissue and measures serum UCP1 to explore tissue remodeling and its relation to ablation outcomes. Primary endpoint is recurrence of any atrial arrhythmia lasting at least 30 seconds after a 90-day blanking period during the 12-month treatment period. The trial stratifies randomization by left atrial diameter and AF type and follows standard ablation protocols with flexible decisions on posterior wall isolation for persistent AF.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18-80 years
* Atrial fibrillation scheduled for first-time catheter ablation (pulmonary vein isolation)
* Estimated glomerular filtration rate (eGFR) \>=25 mL/min/1.73 m2
* Serum potassium \<=5.0 mmol/L

Exclusion Criteria:

* History of prior catheter-based or surgical pulmonary vein isolation
* Current use of other mineralocorticoid receptor antagonists (MRAs)
* Severe renal impairment (eGFR \<25 mL/min/1.73 m2)
* Serum potassium \>5.0 mmol/L
* Severe liver disease (Child-Pugh class C)
* Known hypersensitivity to the investigational drug
* Contraindications to the investigational drug, such as concomitant use of strong CYP3A4 inducers (e.g., rifampicin, carbamazepine, phenytoin, phenobarbital)
* Active cancer or recent chemotherapy
* Women who are pregnant, breastfeeding, or planning to become pregnant during the study period

Where it's running

• National Cheng Kung University Hospital
  Tainan, Taiwan Recruiting

Study contacts

• Study coordinator: Chaoyu Chen
• Email: oripast@gmail.com
• Phone: 886-6-2353535

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.