Predicting Atrial Fibrillation with a Genetic Risk Score

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study enrolls adults at risk for AF and uses a genetic risk score derived from SNP data to predict AF. Participants wear a 7-day continuous ECG patch, provide a blood sample for SNP genotyping, and use a handheld six-lead ECG at home for up to a year, with five in-clinic visits. The goal is to see if combining genetic risk with medical history improves AF prediction over using history alone. The study will develop and validate a scoring system to identify individuals at higher AF risk to inform targeted screening. Overall, the trial integrates genetic testing with wearable and handheld ECG monitoring to enhance early AF detection.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients with symptoms suggestive of paroxysmal atrial fibrillation, such as intermittent palpitations or chest discomfort
* Asymptomatic patients aged 60 or older with at least one of the following risk factors for atrial fibrillation: hypertension, diabetes, coronary artery disease, valvular heart disease, cardiomyopathy, sleep apnea, hyperthyroidism, obesity (BMI greater than 30), or chronic alcohol dependence (drinking more than 3 times per week)

Exclusion Criteria:

* Age under 20 years or over 80 years
* Moderate or severe cognitive impairment
* Previously diagnosed with atrial fibrillation prior to study enrollment
* Does not consent to participate in the study

Where it's running

• The Catholic University of Korea Incheon St. Mary's Hospital
  Incheon, South Korea Recruiting
• The Catholic University of Korea Seoul St. Mary's Hospital
  Seoul, South Korea Recruiting
• The Catholic University of Korea Eunpyeong St. Mary's Hospital
  Seoul, South Korea Recruiting
• The Catholic University of Korea St. Vincent's Hospital
  Suwon, South Korea Recruiting
• The Catholic University of Korea Uijeongbu St. Mary's Hospital
  Uijeongbu-si, South Korea Recruiting

Study contacts

• Principal investigator: Young Choi, MD, PhD — The Catholic University of Korea
• Study coordinator: Young Choi, MD, PhD
• Email: superstar@catholic.ac.kr
• Phone: 82-2-1588-1511

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Pulsed Field vs Cryoballoon for Pulmonary Vein Isolation in Atrial Fibrillation

  This trial tests whether pulsed field ablation can shorten the procedure for first-time PVI in AF patients compared with cryoballoon ablation, while keeping safety and effectiveness similar.

  Recruiting St. Josefs-Hospital Wiesbaden GmbH · Wiesbaden · NCT07910370

• Pulsed Field Ablation vs Cryoablation for Atrial Fibrillation Under Deep Sedation

  This trial tests whether pulsed field ablation (PFA) done under deep sedation works as well as cryoballoon ablation for treating atrial fibrillation, aiming to avoid general anesthesia.

  Recruiting East Sussex Healthcare NHS Trust · Eastbourne · NCT07900685

• Bachmann’s Bundle Pacing vs Right Atrial Appendage Pacing for AF

  This study tests two common atrial pacing methods to see which one is safer over 12 months for people getting a new pacemaker, ICD, or CRT device.

  Recruiting Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) · Pittsburgh, Pennsylvania · NCT07874763

• AI-powered ECG to help diagnose and predict outcomes in heart disease

  Researchers test an AI-enhanced ECG to help diagnose and predict outcomes for people with cardiovascular diseases.

  Recruiting Inha University Hospital · Incheon, Incheon · NCT07856472

• Pace-and-ablate strategy in atrial fibrillation: who benefits and long-term outcomes

  This study looks at adults with atrial fibrillation who underwent AV node ablation with permanent pacing to see who develops pacing-induced problems and how they do long-term.

  Recruiting at 5 sites Insel Gruppe AG, University Hospital Bern · Zabrze and 4 other locations · NCT07852221

• AI-based cardiac analysis using 12-lead and 1-lead ECG

  A clinician-facing pilot test to see if SmartECG-EF helps evaluate heart function using both 12-lead and single-lead ECGs in adults with heart conditions.

  Recruiting Inha University Hospital · Incheon, Incheon · NCT07844434

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.