Digital interventions to manage alcohol consumption and atrial fibrillation severity
Official title: Digitally Rendered Interventions And Knowledge To Limit Ethanol-Associated Atrial Fibrillation Severity
Run by University of California, San Francisco · NCT06995391 · Data updated 2026-11-12
This study is testing whether using a special app and text messages to help people cut down or quit drinking alcohol can improve heart rhythm problems in those with atrial fibrillation.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 21 Years and up |
| Sex | All |
| Enrollment | 1000 (estimated) |
| Sponsor | University of California, San Francisco Academic / other |
| Locations | 1 site (San Francisco, California) |
| Status | Recruiting |
| Started | April 20, 2025 |
| Main results expected | March 1, 2030 |
| Study ends | March 1, 2030 |
| Registry record updated | October 2, 2026 |
| Trial ID | NCT06995391 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are English-speaking adults over 21 with paroxysmal or persistent atrial fibrillation who consume alcohol at least once a month.
✕Probably not a fit
Patients who are currently pregnant, have permanent AF, or are instructed by a healthcare professional to avoid alcohol will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial investigates the effects of two digital health interventions on atrial fibrillation (AF) severity among individuals who consume alcohol. Participants will be randomly assigned to either a guideline-adherent moderate alcohol consumption group or an alcohol abstinence group, receiving weekly messaging through an app and text. The study aims to assess the impact of these interventions on AF episodes and severity over one year, utilizing both self-reported data and objective testing for alcohol consumption. The trial will include at least 1,000 participants aged 21 and older with a history of paroxysmal or persistent AF.
Why it matters
Potential benefit: If successful, this study could provide insights into effective strategies for managing atrial fibrillation severity related to alcohol consumption.
How similar studies have gone: While studies have explored alcohol's impact on AF, this specific approach comparing moderate consumption with abstinence is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Are age 21 years or older * Have a smartphone * Are able to use the Eureka mobile application * Have a history of paroxysmal or persistent atrial fibrillation (AF) * Have consumed alcohol at least once per month on average in the past year * Willing to receive messaging encouraging alcohol abstinence Exclusion Criteria: * Non-english speaker * Currently pregnant or trying to get pregnant * A healthcare professional's instruction to avoid alcohol (for any reason) * Currently incarcerated * Permanent AF (meaning a medical determination has been made that sinus rhythm would definitely never be pursued in this patient) * Are unable to read or sign to provide informed consent
Where it's running
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UCSF Medical Center at Parnassus
San Francisco, California, United States Recruiting
Study contacts
- Principal investigator: Gregory M Marcus, MD, MAS — University of California, San Francisco
- Study coordinator: Gregory M Marcus, MD, MAS
- Email: greg.marcus@ucsf.edu
- Phone: 415-476-5706
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.