Understanding why AF happens and is harder to treat in hypertrophic cardiomyopathy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study examines why atrial fibrillation occurs more often and is harder to treat in patients with hypertrophic cardiomyopathy. Researchers will analyze electrical heart signals and use advanced imaging to map AF behavior in HCM patients. The goal is to gain insights that could inform better treatment strategies for this overlap. Participation is limited to adults with AF and HCM who are planning ablation and can complete follow-up. No interventions are being tested in this study.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Paroxysmal or persistent atrial fibrillation
* Diagnosis of hypertrophic cardiomyopathy
* Patient planning to proceed to atrial fibrillation ablation following clinical consultation
* Age 18-80 years
* Able and willing to provide written informed consent
* Able and willing to comply with study follow up requirements

Exclusion Criteria:

* Any clinical contra-indication to ablation
* Any disease limiting life expectancy to \<1 year
* Potential participant currently pregnant or breast feeding
* Contraindication to MRI including renal dysfunction (eGFR\<30ml/min)
* Unable to understand verbal or written explanations given in English

Where it's running

• Guy's and St Thomas' NHS Foundation Trust
  London, United Kingdom Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.