Condition

Endothelial Dysfunction clinical trials and research

• 38Clinical trials
• 40NIH research projects
• 11Countries

Newest Endothelial Dysfunction clinical trials

All recruiting trials (38)

• Endothelial extracellular vesicles in kids with newly diagnosed high blood pressure

  This study tests whether levels of endothelial extracellular vesicles are different in children with new, untreated primary hypertension compared to normotensive children.

  Recruiting Josip Juraj Strossmayer University of Osijek · Osijek · NCT07728643

• TB-500 (thymosin beta 4 fragment) to improve blood vessel function in people with stable atherosclerotic cardiovascular disease

  This trial will test whether TB-500 (a fragment of thymosin beta 4) is safe and can improve blood vessel function in adults aged 40–75 with stable ASCVD.

  Recruiting Phase 1/2 Hudson Biotech · Shenzhen, Guangdong · NCT07487363

• Statin effects on hormones and erectile function in middle-aged men

  This will test whether different doses of pitavastatin or rosuvastatin change sex hormone levels and improve erectile function in sexually active men aged 40-65 with high cardiovascular risk.

  Recruiting Phase 2 Lomonosov Moscow State University Medical Research and Educational Center · Moscow · NCT07460960

• Effect of pre-surgery (neoadjuvant) therapy on surgical outcomes in colorectal cancer

  We will test whether pre-surgery (neoadjuvant) therapy changes tiny blood vessels, increases tissue scarring, and raises the risk of wound and other perioperative complications in adults having colorectal cancer surgery.

  Recruiting Osijek University Hospital · Osijek · NCT07422974

• How Lipoprotein(a) affects artery stiffness, blood vessel lining, and heart muscle movement

  This project will see if higher Lipoprotein(a) levels are linked to stiffer arteries, worse endothelial function, and changes in left atrial and left ventricular motion in adults 18–75.

  Recruiting at 2 sites University of Athens · Athens, Attica and 1 other locations · NCT07324902

• Testosterone and blood vessel health after spinal cord injury

  This research tests if low testosterone in men with recent motor-complete paraplegia is linked to poorer blood vessel function and higher blood markers of endothelial injury.

  Recruiting Craig Hospital · Englewood, Colorado · NCT07227740

• Blood vessel (endothelial) dysfunction after spinal cord injury

  This research will test whether blood vessels in adults with chronic paraplegia do not widen properly and whether circulating endothelial microvesicles help explain those changes by comparing them to adults without an injury.

  Recruiting Craig Hospital · Englewood, Colorado · NCT07227727

• How childhood adversity and SIRT1 affect early blood vessel aging.

  This project will test whether taking nicotinamide riboside can boost SIRT1 and improve blood vessel function in 18–30-year-olds with high levels of childhood adversity compared with those with no ACEs.

  Recruiting University of Wisconsin, Madison · Iowa City, Iowa and 1 other locations · NCT07073352

• NightWare use for cardiovascular health in women with PTSD-related nightmares

  This study tests whether NightWare can improve heart and kidney health biomarkers in premenopausal women who have PTSD-related nightmares.

  Recruiting at 2 sites University of Colorado, Denver · Aurora, Colorado and 1 other locations · NCT07021014

• Cytisine treatment for helping smokers quit and its effects on heart health

  This study tests if a plant-based treatment called cytisine can help adult smokers quit and also looks at how it affects their heart health during and after the treatment.

  Recruiting University of Athens · Athens, Haidari · NCT06885970

• Understanding retinal blood vessel changes in Fabry disease

  This study is trying to see how changes in the tiny blood vessels in the eyes of people with Fabry disease can help predict heart problems and track how well treatments are working.

  Recruiting Technical University of Munich · München, Bavaria · NCT06758648

• EndoPAT to measure blood vessel health in men with erectile dysfunction and hypogonadism

  This project will test whether EndoPAT can detect changes in blood-vessel function in men with vasculogenic ED or hypogonadism before and 3–6 months after starting daily low-dose PDE5 inhibitors or testosterone therapy.

  Recruiting University of California, Irvine · Newport Beach, California · NCT06720597

• Investigating the role of endothelin-1 in blood vessel function after gestational diabetes

  This study is testing how a substance called endothelin-1 affects blood vessel function in women who had gestational diabetes to see if insulin can help improve their heart health after pregnancy.

  Recruiting Early Phase 1 University of Iowa · Iowa City, Iowa · NCT06547619

• Investigating how inflammation affects blood vessel health in e-cigarette users

  This study is testing how inflammation affects blood vessel health in young adults who use e-cigarettes compared to those who don’t, while also seeing if an anti-inflammatory medication can help improve their vascular function.

  Recruiting at 2 sites Early Phase 1 University of Iowa · Iowa City, Iowa and 1 other locations · NCT06489249

• Investigating how spinal cord injuries affect heart health

  This study looks at how spinal cord injuries affect heart health in adults and tries to find out why they may have a higher risk of heart problems.

  Recruiting Craig Hospital · Englewood, Colorado · NCT06443151

• NightWare for reducing nightmares and supporting heart health in Veterans with PTSD

  This trial will test whether a prescription wrist-wearable app called NightWare can reduce PTSD-related nightmares and improve sleep and cardiovascular health in Veterans.

  Recruiting VA Office of Research and Development · Aurora, Colorado · NCT06419959

• Infusion of iloprost for 72 hours in patients on mechanical ventilation with acute respiratory failure

  This study is testing if giving a medication called iloprost for 72 hours can help patients on mechanical ventilation with severe breathing problems caused by infections feel better and live longer.

  Recruiting at 5 sites Phase 2 Copenhagen University Hospital, Rigshospitalet · Copenhagen and 4 other locations · NCT06319274

• Using Atorvastatin to Prevent Stroke After Flow Diverter Implantation

  This study is testing if the cholesterol-lowering drug atorvastatin can help prevent strokes in patients who have had a flow diverter implanted for unruptured brain aneurysms.

  Recruiting Phase 4 Zhujiang Hospital · Guangzhou, Guangdong · NCT06308952

• Using a mandibular advancement device to help with sleep apnea when stopping CPAP

  This study is testing if a mouthpiece can help people with sleep apnea manage their symptoms and heart health when they stop using their CPAP machine for a short time.

  Recruiting University Hospital, Angers · Angers · NCT05939934

• Non-surgical treatment for gum disease's effect on blood vessel health

  This study is testing whether a non-surgical gum treatment can improve blood vessel health in people with gum disease and healthy individuals.

  Recruiting University of Catania · Catania · NCT05906810

• Effects of a medication on blood vessel function and organ injury in heart surgery patients

  This study tests if a medication called vericiguat can improve blood vessel function and reduce kidney and brain injury in patients having heart surgery.

  Recruiting Phase 4 Vanderbilt University Medical Center · Nashville, Tennessee · NCT05812755

• Improving blood vessel health in frail older adults through exercise and conditioning

  This study is testing whether high-intensity exercise and a special conditioning technique can help improve blood vessel health in frail older adults.

  Recruiting Phase 2 Medical College of Wisconsin · Wauwatosa, Wisconsin · NCT05808686

• Assessing the safety of EO2002 injections for corneal conditions

  This study is testing if EO2002 injections are safe for people with corneal conditions like Fuchs' dystrophy or pseudophakic bullous keratopathy.

  Recruiting Phase 1 Asociación para Evitar la Ceguera en México · Mexico City, Mexico City · NCT05636579

• Micro-doses of physical activity for improving blood vessel health in COPD patients

  This study tests if short walks can help improve blood vessel health in people with COPD who sit for long periods.

  Recruiting University of British Columbia · Kelowna, British Columbia · NCT05553223

• Exploring endothelial cell dysfunction in blood cancers

  This study is trying to see how blood cancer treatments affect the tiny blood vessel cells in patients and if this can help predict complications and improve care.

  Recruiting University Hospital Heidelberg · Heidelberg, Baden-Wurttemberg · NCT05502887

• Improving blood flow in type 1 diabetes with medication and exercise

  This study is testing whether a combination of a medication called dulaglutide and exercise can improve blood flow in adults with type 1 diabetes.

  Recruiting Phase 2 AdventHealth Translational Research Institute · Orlando, Florida · NCT05478707

• Testing a B-vitamin supplement to reduce optic disc edema in astronauts

  This study is testing if a daily B-vitamin supplement can help astronauts reduce swelling in their eyes during long space missions.

  Recruiting Phase 1 National Aeronautics and Space Administration (NASA) · Houston, Texas · NCT05366933

• Optimizing blood flow during heart surgery

  This study is trying to see if using a pulsing blood flow during heart surgery helps patients recover better and have fewer problems with their organs compared to a steady flow.

  Recruiting University of Colorado, Denver · Aurora, Colorado · NCT05344573

• Effects of Metformin and Automated Insulin Delivery on Youth with Type 1 Diabetes

  This study is testing if adding metformin and an automated insulin delivery system can help young people with type 1 diabetes improve their kidney and heart health.

  Recruiting Phase 1 Seattle Children's Hospital · Aurora, Colorado and 1 other locations · NCT05065372

• Inspiratory muscle training to lower blood pressure in postmenopausal women

  This study is testing if a special breathing exercise can lower blood pressure more effectively than regular walking in postmenopausal women with high blood pressure.

  Recruiting University of Colorado, Boulder · Boulder, Colorado · NCT05000515

• Improving blood vessel function in African Americans using galantamine

  This study is testing if a medication called galantamine can improve blood vessel function and reduce stress on the blood vessels in African Americans who may be at higher risk for heart problems.

  Recruiting Phase 1/2 Vanderbilt University Medical Center · Nashville, Tennessee · NCT04769206

• Understanding the role of glycocalyx integrity in preventing major cardiovascular events

  This study is looking to see if the health of a protective layer in blood vessels can help prevent serious heart problems in people getting routine check-ups.

  Recruiting University of Athens · Athens, Attica · NCT04646252

• Evaluating vascular aging after COVID-19 infection

  This study is testing how COVID-19 affects blood vessel health and aging in adults by checking their heart and blood vessel function six and twelve months after infection.

  Recruiting at 3 sites Assistance Publique - Hôpitaux de Paris · Nancy and 2 other locations · NCT04558450

• Evaluating puberty suppression effects on health in transgender youth

  This study is testing how puberty suppression affects health, like insulin sensitivity and heart health, in transgender girls compared to boys over six months.

  Recruiting University of Colorado, Denver · Aurora, Colorado · NCT04482374

• Investigating microvascular dysfunction in obese individuals

  This study is testing if exercise can improve blood vessel function in people with class 2 obesity and metabolic syndrome, focusing on how certain chemicals in the body are affected.

  Recruiting Florida State University · Tallahassee, Florida · NCT04087655

• Using bright light therapy to improve outcomes in cardiac surgery patients

  This study tests if bright light therapy can help heart surgery patients by reducing heart damage and improving their recovery.

  Recruiting University of Colorado, Denver · Denver, Colorado · NCT03822949

• How changes in brain blood flow affect breathing during sleep

  This project will test whether temporarily lowering blood flow to the brain changes how healthy adults' breathing responds to low oxygen and high carbon dioxide during normal sleep and short periods of low oxygen.

  Recruiting Phase 1/2 University of Calgary · Calgary, Alberta · NCT03255408

• Collecting blood and urine samples for research on cardiovascular health

  This study is collecting blood and urine samples from healthy people and patients to see how certain biological markers relate to heart health and inflammation.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT03253705

NIH-funded research (40)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Endothelial dysfunction in Alzheimer’s disease: a data-driven model for diagnosis and prognosis

  This research explores brain blood vessel problems in people with Alzheimer’s to find new biomarkers that could help diagnose and predict progression.

  NIH research Saint Louis University · Saint Louis, United States · NIH-11518818

• Microvascular and Endothelial Health and Postoperative Atrial Fibrillation

  A heart-surgery study aims to understand how tiny blood vessels in the atria affect the risk of developing atrial fibrillation after surgery and what this means for patients.

  NIH research University of South Florida · Tampa, United States · NIH-11418469

• Endothelial problems and healing after trauma-related blood clotting problems

  This project looks at how blood vessel lining cells contribute to abnormal clotting after severe injury and whether restoring them can improve outcomes.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11392317

• New ways to understand and treat sepsis-related blood vessel dysfunction

  A doctor-scientist at a major university is researching how sepsis harms the lining of blood vessels and ways to detect or counteract it to prevent organ failure.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11390478

• How the viral protein NS1 causes blood vessel leak in dengue, Zika, and related infections

  This work looks at how a viral protein called NS1 harms blood vessel linings in people with dengue, Zika, or similar infections.

  NIH research University of California Berkeley · Berkeley, United States · NIH-11379940

• PAI-1 as a target to protect mothers’ blood vessels in preeclampsia

  A study at Yale aims to see if blocking a molecule called PAI-1 can help protect a pregnant person’s blood vessels and reduce complications in preeclampsia.

  NIH research Yale University · New Haven, United States · NIH-11378715

• Platelet-driven metabolic stress and thrombo-inflammation in PAH

  A project looks at how stressed platelets contribute to endothelial dysfunction and lung blood vessel disease in pulmonary arterial hypertension, with potential to reveal new targets to help patients.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11378581

• Understanding how fat tissue around the heart and heart vessels go wrong in type 1 diabetes

  Researchers will study heart-specific fat and blood vessels at the cellular level in adults with type 1 diabetes to understand why cardiovascular disease is more dangerous in this group.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11369262

• Understanding and reversing blood vessel problems in peri-implant inflammation

  A study will explore why blood vessels in mouth implants get inflamed and test a drug approach to reverse this process to protect implants.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-11351730

• Hemolysis and Blood Vessel Health After Trauma

  A clinician-researcher at Case Western Reserve University is studying how destruction of red blood cells after severe injury may harm blood vessels and organs, with a goal to find ways to prevent these problems.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11350623

• Role of belly fat in obesity-related blood vessel problems

  This grant explores how visceral fat might cause blood vessel dysfunction in obesity, with the goal of reducing cardiovascular risk for people with obesity.

  NIH research University of Delaware · Newark, UNITED STATES · NIH-11341897

• Understanding blood vessel changes in Alzheimer’s

  This project looks for proteins and RNA signs of blood-vessel damage in people with Alzheimer’s to see how those changes relate to memory and brain scans.

  NIH research Saint Louis University · Saint Louis, United States · NIH-11328208

• How a common ALDH2 gene change increases smoking-related blood vessel damage

  Researchers will look at how smoking harms the cells that line blood vessels in people with the ALDH2*2 genetic variant to understand why their heart disease risk may be higher.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11298320

• How CEBPβ affects artery-lining damage and plaque buildup

  This work looks at how a molecule called CEBPβ changes how blood flow harms the cells that line arteries and contributes to atherosclerosis, using mouse models and human artery cells in the lab.

  NIH research Emory University · Atlanta, United States · NIH-11286615

• How fat-tissue particles affect blood vessel health in type 2 diabetes and whether exercise or weight-loss surgery can help

  This project looks at whether tiny particles released from fat harm blood vessels in adults with type 2 diabetes and if exercise or metabolic surgery can reverse those effects.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11247948

• Understanding heart disease in type 1 diabetes through fat and blood vessel cells

  This research explores how fat around the heart and blood vessel cells contribute to heart disease in people with type 1 diabetes.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11194469

• How obesity harms blood vessels in belly fat

  This project looks at whether a fat-uptake protein called CD36 and a blood-flow channel named Kir2.1 explain why obesity weakens the lining of blood vessels in belly fat in adults.

  NIH research University of Delaware · Newark, UNITED STATES · NIH-11191484

• Repairing blood vessel damage that causes bleeding and clots after severe injury

  This project tests whether signals and plasma treatments can protect and repair the lining of blood vessels to reduce bleeding and dangerous clots in people with severe traumatic injuries.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11178361

• Understanding Platelet Stress in Pulmonary Hypertension

  This work explores how stress in blood platelets might contribute to blood vessel damage in people with pulmonary hypertension.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11172429

• Treating blood-vessel damage in lupus-related kidney disease

  Researchers are trying sepiapterin, a compound that may improve blood-vessel cell health and reduce kidney inflammation for people with lupus nephritis.

  NIH research Ralph H Johnson VA Medical Center · Charleston, United States · NIH-11132601

• Understanding Blood Vessel Damage in Aortic Weakness and Tears

  This research explores how damage to the inner lining of blood vessels contributes to serious conditions like aortic aneurysms and dissections.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11115607

• How blood mutations in military personnel affect heart health

  This study is looking at how a specific blood mutation, called JAK2V617F, affects military personnel and their chances of developing heart problems, especially for those with a condition known as CHIP, to help us understand more about heart health.

  NIH research Northport VA Medical Center · Northport, United States · NIH-11098538

• Investigating the role of fat cells in heart disease for people with type 1 diabetes

  This study is looking at how fat cells around the heart might play a role in heart disease for people with type 1 diabetes, and it aims to find out what changes happen in these cells that could lead to heart problems.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11074419

• Investigating how blood flow affects artery health and disease

  This study is looking at how different blood flow patterns can affect the buildup of plaque in your arteries, which can lead to heart problems, and it hopes to find new ways to treat these issues by focusing on a specific protein that might be important in this process.

  NIH research Emory University · Atlanta, United States · NIH-11017817

• How fat cell particles affect blood vessel health in diabetes and the benefits of exercise and surgery

  This study is looking at how tiny particles from fat cells might cause blood vessel problems in people with obesity-related type II diabetes, and it aims to find out if things like exercise and surgery can help improve blood vessel health.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11001122

• Understanding how dengue virus affects blood vessel function

  This study is looking at how a part of the dengue virus affects the cells that line our blood vessels, which could help us find new ways to prevent or treat serious problems caused by dengue.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11001087

• Understanding and repairing blood vessel damage after severe trauma

  This study is looking at how trauma can affect blood vessel function and lead to complications after serious injuries, with the goal of finding better treatments for patients who are critically hurt.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-10930121

• Finding new treatments for brain problems linked to the APOE4 gene

  This study is looking at how a specific gene called APOE4 impacts the blood vessels in the brain, which is important for keeping our brains healthy, and it aims to find new treatments that could help people with Alzheimer's and other memory-related issues.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-10909260

• Understanding how blood vessel dysfunction occurs in cerebral malaria and ways to restore it

  This study is looking at how malaria can cause problems in the blood vessels of the brain, which can lead to serious issues like swelling, and it's testing new ways to help fix the damage caused by the infection.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-10897766

• How platelet stress affects blood vessel function in pulmonary hypertension

  This study is looking at how platelets, which are tiny cells in your blood, can cause inflammation and damage to blood vessels in people with pulmonary arterial hypertension (PAH), and it hopes to find new ways to help improve blood vessel health for those living with this condition.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-10896276

• Investigating how a gut-derived compound affects blood vessel function

  This study is looking at how a substance called TMAO, which comes from certain foods and is made by gut bacteria, affects blood vessel health and could lead to heart problems, with the hope of finding new ways to help people with cardiovascular diseases.

  NIH research Texas A&m University Health Science Ctr · College Station, United States · NIH-10896250

• Understanding how low blood flow affects blood vessel function

  This study is looking at how low blood flow affects the inner lining of blood vessels and aims to find new ways to help people with conditions like peripheral artery disease by understanding the signals that keep blood vessels healthy.

  NIH research University of South Alabama · Mobile, United States · NIH-10886561

• Investigating how obesity affects blood vessel health through gene regulation

  This study is looking at how being overweight can harm your blood vessels and raise your chances of heart disease, and it’s specifically exploring how a certain gene might play a role in this process, so we can better understand and help people who are dealing with obesity-related heart issues.

  NIH research University of Houston · Houston, United States · NIH-10880430

• Improving heart and blood vessel health by enhancing nerve activity

  This study is looking at how a medication called galantamine can help improve heart health by reducing stress in blood vessels, especially for African Americans who often face higher risks of heart problems.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-10857152

• Investigating how neuraminidase affects blood vessel function in type 2 diabetes

  This study is looking at how a specific enzyme affects blood vessel health in people with type 2 diabetes, aiming to find new ways to help improve blood flow and overall heart health.

  NIH research University of Missouri-Columbia · Columbia, United States · NIH-10851880

• Understanding how blood vessel cell damage contributes to serious aortic conditions

  This study is looking at how damage to the cells in our blood vessels might lead to serious problems like aortic aneurysms and dissections, and it’s for anyone interested in understanding how inflammation and cell health can affect the aorta, with hopes of finding better ways to treat and prevent these conditions.

  NIH research Baylor College of Medicine · Houston, United States · NIH-10848498

• Investigating how SUMO2 affects blood vessel health and heart disease

  This study is looking at how a tiny protein called SUMO2 affects the cells that line our blood vessels and may contribute to heart problems like atherosclerosis, using specially modified mice to learn more about its impact on heart health.

  NIH research University of Iowa · Iowa City, United States · NIH-10812338

• Understanding how blood vessel problems affect Alzheimer’s disease

  This study is looking at how problems with blood vessels might affect Alzheimer’s disease by checking for certain markers in the brain and spinal fluid, and it’s for anyone interested in understanding more about Alzheimer’s and its early signs.

  NIH research University of New Mexico Health Scis Ctr · Albuquerque, United States · NIH-10737969

• Investigating how malondialdehyde affects blood vessel health in atherosclerosis

  This study is looking at how a substance called malondialdehyde (MDA) can harm blood vessels and lead to heart problems, and it’s testing whether a special antibody can help protect against this damage, which could lead to better ways to prevent or treat heart disease for patients.

  NIH research University of Texas Hlth Science Center · San Antonio, United States · NIH-10687848

• Investigating how a specific protein modification affects blood vessel health and heart disease.

  This study is looking at how a specific change in a protein might cause problems in blood vessels that can lead to heart disease, and it's aimed at finding new ways to help improve heart health for patients.

  NIH research Boston University Medical Campus · Boston, United States · NIH-10551314

Related topics

Quick answers

How many Endothelial Dysfunction clinical trials are recruiting right now?

38, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 11 countries. The most sites are in United States (21 trials), Greece (3 trials), Croatia (2 trials), Canada (2 trials), France (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 4, Phase 1/2: 3, Phase 1: 3, Phase 4: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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