Testing a B-vitamin supplement to reduce optic disc edema in astronauts

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This project aims to evaluate the effectiveness of a daily nutraceutical supplement containing bioactive B vitamins to mitigate optic disc edema in astronauts during long-duration space missions. The approach focuses on optimizing the one-carbon metabolic pathway to enhance endothelial function and collagen elasticity, potentially minimizing retinal thickness changes. The study will involve comprehensive assessments of ocular health, vascular function, and nutritional status through blood sample analyses and other health metrics collected at various time points before and after spaceflight.

Why it matters

Who can join: the full rules

Inclusion Criteria:

• Must be astronauts selected for 6-12 month missions on the International Space Station

Exclusion Criteria:

• Subjects taking B-vitamin supplements

Where it's running

• Johnson Space Center
  Houston, Texas, United States Recruiting

Study contacts

• Principal investigator: Sara R Zwart, PhD — Utmb
• Study coordinator: Sara Zwart, PhD
• Email: sara.zwart-1@nasa.gov
• Phone: 2814833753

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.