Condition

Arterial Stiffness clinical trials and research

• 23Clinical trials
• 20NIH research projects
• 15Countries

Newest Arterial Stiffness clinical trials

All recruiting trials (23)

• Sleep and arterial function in hypertensive patients with poor sleep quality

  This trial tests whether using cognitive-behavioural therapy for insomnia can improve artery health and well-being in adults with high blood pressure and poor sleep.

  Recruiting Unidade Local de Saúde do Alto Ave, EPE · Guimarães, Braga District · NCT07789535

• Can mouth health and chewing help explain arterial stiffness in healthy adults

  This study tests whether a profile of oral health and function adds information about central arterial stiffness beyond traditional risk factors in healthy adults.

  Recruiting VASCage GmbH · Innsbruck, Tyrol · NCT07736222

• How Lipoprotein(a) affects artery stiffness, blood vessel lining, and heart muscle movement

  This project will see if higher Lipoprotein(a) levels are linked to stiffer arteries, worse endothelial function, and changes in left atrial and left ventricular motion in adults 18–75.

  Recruiting at 2 sites University of Athens · Athens, Attica and 1 other locations · NCT07324902

• Dapagliflozin to prevent chemotherapy-related heart damage in breast cancer

  We will test if taking dapagliflozin 10 mg daily prevents heart and blood-vessel damage in adult women receiving anthracycline chemotherapy for breast cancer.

  Recruiting Phase 2 University Medical Centre Ljubljana · Ljubljana · NCT07245069

• Upper-arm aerobic exercise for arterial stiffness in women treated for breast cancer.

  This trial will test whether an upper-extremity aerobic exercise program can reduce arterial stiffness in women aged 40–69 who are at least 15 months after breast cancer surgery and are currently physically inactive.

  Recruiting Hacettepe University · Ankara, State · NCT07070778

• Contactless vibrometer pulse‑wave test for heart and artery health

  This pilot will try a contactless laser‑Doppler vibrometry and microwave radar device (Cardio P4) in people aged 58–72 to see if it can detect arterial stiffness and signs of coronary artery disease, aortic stenosis, or heart failure.

  Recruiting HJN Sverige AB/Neko Health · Stockholm · NCT07001007

• Cytisine treatment for helping smokers quit and its effects on heart health

  This study tests if a plant-based treatment called cytisine can help adult smokers quit and also looks at how it affects their heart health during and after the treatment.

  Recruiting University of Athens · Athens, Haidari · NCT06885970

• Using blueberries to improve health in women with prediabetes

  This study is testing if eating freeze-dried wild blueberry powder can help improve health, brain function, and gut health in women with prediabetes.

  Recruiting Georgia State University · Atlanta, Georgia · NCT06735651

• Effects of wild blueberries on heart, brain, and gut health in adults with high blood pressure

  This study tests if eating freeze-dried wild blueberries can improve heart health, brain function, and gut health in adults aged 45-65 with high blood pressure.

  Recruiting Georgia State University · Atlanta, Georgia · NCT06735599

• Effects of California grapes on gut and heart health in overweight adults

  This study is testing whether eating freeze-dried grape powder can improve gut and heart health in overweight adults aged 45-70.

  Recruiting University of California, Davis · Davis, California · NCT06544954

• Using empagliflozin to reduce arterial stiffness in older adults

  This study is testing if a medication called empagliflozin can help older adults aged 60 to 80 reduce stiffness in their arteries over 12 weeks.

  Recruiting Phase 2/3 University of Missouri-Columbia · Columbia, Missouri · NCT06506422

• Evaluating Pulse Wave Velocity Changes in Stroke Patients After Rehabilitation

  This study is testing how four weeks of rehabilitation affects blood vessel stiffness in stroke patients to see if it helps them recover better.

  Recruiting Shin Kong Wu Ho-Su Memorial Hospital · Taipei · NCT06224517

• Risk markers of arterial aging in older adults — Paris Prospective III-2

  This follow-up will re-examine people who took part in the original Paris cohort to measure changes in arterial stiffness and baroreflex over about 12–16 years and see if those changes predict later heart and blood vessel disease.

  Recruiting Institut National de la Santé Et de la Recherche Médicale, France · Paris · NCT06079424

• High-intensity exercise program for older adults with HIV to improve vascular and cognitive health

  This study tests whether a 16-week high-intensity exercise program can help older adults with HIV improve their heart and brain health compared to a moderate exercise routine.

  Recruiting University of Alabama at Birmingham · Birmingham, Alabama · NCT05965518

• Vitamin K2 for adults with episodic migraine

  This will test whether vitamin K2 supplements can reduce how often adults with episodic migraine have attacks and lower arterial stiffness.

  Recruiting Lebanese American University · Beirut, Beirut · NCT05943457

• Detecting long-term complications of diabetes in children and adolescents

  This study is trying to find early signs of long-term diabetes complications in kids and teens with type 1 diabetes to help improve their care and health.

  Recruiting Steno Diabetes Center Copenhagen · Herlev, Herlev · NCT05159856

• Observing the progression of CADASIL over time

  This study is tracking people with CADASIL and healthy volunteers over nine years to see how the disease affects blood vessels and overall health.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT05072483

• Effects of cross-sex hormone therapy on metabolism and eating behavior

  This study looks at how cross-sex hormone therapy affects metabolism, eating habits, and overall health in people undergoing this treatment.

  Recruiting University of Leipzig · Leipzig, Saxony · NCT04838249

• Predicting preeclampsia early using arterial stiffness in high-risk pregnancies

  This study is testing a new way to spot early signs of preeclampsia in high-risk pregnancies by measuring how stiff blood vessels are, along with other tests, to help improve care for moms and babies.

  Recruiting McGill University Health Centre/Research Institute of the McGill University Health Centre · Montreal, Quebec · NCT04783597

• Understanding the role of glycocalyx integrity in preventing major cardiovascular events

  This study is looking to see if the health of a protective layer in blood vessels can help prevent serious heart problems in people getting routine check-ups.

  Recruiting University of Athens · Athens, Attica · NCT04646252

• Evaluating vascular aging after COVID-19 infection

  This study is testing how COVID-19 affects blood vessel health and aging in adults by checking their heart and blood vessel function six and twelve months after infection.

  Recruiting at 3 sites Assistance Publique - Hôpitaux de Paris · Nancy and 2 other locations · NCT04558450

• Examining blood pressure patterns in people at risk for heart disease

  This study looks at daily blood pressure patterns in people at risk for heart disease, especially those with kidney issues, to see how these patterns might help identify who could benefit from specific treatments.

  Recruiting University of Edinburgh · Edinburgh · NCT04522765

• Effects of long-term lipid-lowering therapy in heart attack patients

  This study is testing if a long-term treatment with atorvastatin can help heart attack patients lower their cholesterol and improve their heart health.

  Recruiting Phase 4 Penza State University · Penza · NCT04347434

NIH-funded research (20)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Arterial stiffness, cognition, and equol: a trial to help aging adults

  A large, multi-site study tests whether taking equol daily for two years can slow arterial stiffness, brain changes, and thinking difficulties in older adults without dementia.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11519686

• Arterial health after pregnancy complications: uncovering heart disease risk in women

  This project looks at why some women who had complications during pregnancy are at higher risk for heart disease later and how to spot those at risk earlier.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11423644

• Intersection of a vascular pathway with blood pressure control

  A study in adults will look at how a specific protein pathway in blood vessels affects blood pressure, arterial stiffness, and vascular function.

  NIH research Medical College of Wisconsin · Milwaukee, United States · NIH-11321576

• Equol for artery health and memory in older adults

  Sees if taking a daily 10 mg equol pill for 24 months helps slow memory decline and improve artery stiffness and brain white matter in people aged 70 and older without dementia.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11295480

• Artery stiffness and reflected blood pressure after complicated pregnancies and future heart risk

  Researchers are measuring artery stiffness and blood-pressure wave patterns in women who had pregnancy complications to find early signs of future heart disease.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11171369

• Investigating arterial stiffness in mothers and infants to prevent heart disease

  This study is looking at how the stiffness of blood vessels affects the heart health of pregnant women and their babies, and it aims to find ways to lower the risk of heart disease for both moms and kids over three years after childbirth.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11170270

• Investigating arterial stiffness in mothers and infants to prevent heart disease

  This study is looking at how stiff arteries can impact the heart health of moms and their babies during and after pregnancy, especially for non-Hispanic Black and Latina women, to help create better care practices that keep both mothers and their children healthy.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11170261

• How a specific pathway affects blood pressure and artery health

  This study is looking at how a certain cellular process affects blood pressure and the stiffness of blood vessels, with the goal of finding new ways to help people with high blood pressure feel better and improve their heart health.

  NIH research Medical College of Wisconsin · Milwaukee, United States · NIH-11034272

• Effects of equol supplementation on cognitive decline and arterial stiffness in older adults

  This study is looking at whether taking a daily soy-based supplement called equol can help improve brain health and blood vessel flexibility in people aged 70 and older who don’t have dementia, by comparing the effects of the supplement to a placebo over two years.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11019802

• Investigating how estrogen receptors in smooth muscle cells affect arterial stiffness as we age

  This study is looking at how a hormone called estrogen affects blood vessel health in older women, especially how it might relate to stiff arteries and heart disease after menopause.

  NIH research Tufts Medical Center · Boston, United States · NIH-10995879

• Understanding how arterial stiffness affects blood pressure management in older veterans

  This study is looking at how stiff arteries affect blood pressure in older veterans with high blood pressure, and it aims to find better ways to treat them by using simple tests and genetic information to personalize their care.

  NIH research Wm S. Middleton Memorial Veterans Hosp · Madison, United States · NIH-10912973

• Investigating arterial stiffness in mothers and infants to prevent heart disease

  This study is looking at how the stiffness of blood vessels in pregnant women and their babies can help us understand the risk of heart problems later on, especially for non-Hispanic Black and Latina families, so we can find better ways to keep both moms and their kids healthy.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-10908540

• Understanding heart health risks in women after pregnancy complications

  This study is looking at how problems during pregnancy, like high blood pressure and early delivery, might affect a woman's heart health later on, especially for those who are not yet in menopause, and it aims to find ways to spot who might be at risk for heart issues in the future.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-10906743

• How stress and resilience affect heart health in perimenopausal Latinas

  This study looks at how stress from things like discrimination and family responsibilities, as well as positive support from friends and self-kindness, affects heart health in Latinas going through perimenopause, aiming to find ways to improve their well-being during this important time in their lives.

  NIH research University of Iowa · Iowa City, United States · NIH-10905161

• Understanding how aging affects blood vessel stiffness and high blood pressure

  This study is looking at how aging affects blood vessel stiffness and high blood pressure, focusing on a gene called KDM6A that might help keep your blood vessels flexible, with the goal of finding ways to improve heart health for older adults.

  NIH research University of Tennessee Health Sci Ctr · Memphis, United States · NIH-10678777

• Understanding how carnitine affects artery stiffness in teenagers

  This study is looking at how taking carnitine supplements might affect blood vessel stiffness in teenagers, which can help us understand more about heart health and blood pressure.

  NIH research Baylor College of Medicine · Houston, United States · NIH-10675579

• The relationship between arterial stiffness and brain health in African Americans

  This study is looking at how stiff arteries might affect brain health, especially for African Americans who are more likely to develop Alzheimer's disease, and it will use a simple test to measure artery stiffness while considering factors like diabetes and high blood pressure.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-10614288

• Using nicotinamide riboside to lower blood pressure and improve artery health in older adults

  This study is looking at whether taking nicotinamide riboside can help lower high blood pressure and improve blood vessel health in middle-aged and older adults, offering a friendly option for those who might find lifestyle changes challenging.

  NIH research University of Colorado · Boulder, UNITED STATES · NIH-10539289

• The link between arterial stiffness and brain health in African Americans

  This study is looking at how stiff arteries might impact brain health, especially in African Americans, to see if it plays a role in memory problems and Alzheimer's disease, and it will involve around 2,700 people aged 41 to 104 from the Jackson Heart Study.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-10398882

• The relationship between arterial stiffness and brain health in U.S. Hispanics/Latinos

  This study is looking at how stiff arteries might impact brain health and thinking skills, especially in older Hispanic/Latino adults, to see if there’s a link between heart health and conditions like Alzheimer's disease.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-10318668

Related topics

Quick answers

How many Arterial Stiffness clinical trials are recruiting right now?

23, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 15 countries. The most sites are in United States (6 trials), Greece (3 trials), France (2 trials), Canada (1 trial), Portugal (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2/3: 1, Phase 2: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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