Endothelial dysfunction in Alzheimer’s disease: a data-driven model for diagnosis and prognosis
Official title: Elucidating the Role of Endothelial Dysfunction in Alzheimer Disease: Towards A New Data-Driven Disease Model
Funded at Saint Louis University · NIH-11518818 · Data updated 2026-11-12
This research explores brain blood vessel problems in people with Alzheimer’s to find new biomarkers that could help diagnose and predict progression.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Saint Louis University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | September 15, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $723,824 |
| NIH project number | 4R01AG083744-03 |
| Project ID | NIH-11518818 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults with late-onset sporadic Alzheimer’s disease, individuals with healthy aging, and patients with non-AD dementias who have long-term cognitive and biomarker data.
✕Less likely to help
Patients without access to CSF or brain biomarker testing or with non-endothelial pathways may see limited direct benefit.
What this research studies
Researchers will use advanced protein and gene analyses to measure endothelial biomarkers in CSF and brain samples from thousands of participants across AD, healthy controls, and other dementias over many years. By linking these endothelial markers with cognitive and imaging outcomes, the study aims to build a data-driven model of how vascular dysfunction contributes to Alzheimer’s. The project builds on existing longitudinal cohorts to understand whether endothelial changes occur early and could inform future diagnostics or treatments. If successful, this could provide more precise ways to identify and monitor Alzheimer’s based on brain vessel health.
Why it matters
Potential benefit: Could lead to earlier and more accurate diagnosis and prognosis by highlighting vascular factors in Alzheimer’s.
How similar studies have gone: Preliminary data suggest endothelial biomarkers correlate with outcomes, supporting potential translational value of this approach.
Where this research is happening
-
Saint Louis University
Saint Louis, United States Active
Researchers
- Principal investigator: Tarawneh, Rawan — Saint Louis University
- Study coordinator: Tarawneh, Rawan
Related research
Other NIH-funded projects on the same topics.
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Understanding Alzheimer's Genetic Risk in African and Admixed African-American People
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Genetic Risk for Alzheimer’s in African and admixed African-American communities
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.