Exploring endothelial cell dysfunction in blood cancers

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational project investigates the role of endothelial cell dysfunction in patients with hematological neoplasms. It focuses on understanding how anti-neoplastic and immune therapies affect the endothelial layer and the associated risks of endothelial complications. The study utilizes sublingual in vivo microscopy with the Glycocheck microscope to assess endothelial vulnerability markers and their prognostic significance for treatment-related mortality. By examining the relationship between endothelial activation and stress index (EASIX) and patient outcomes, the research aims to enhance diagnostic criteria for endothelial complications following hematological therapies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Suspected or proven diagnosis of hematological neoplasms according to the WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues;
* Age ≥18 years;
* Ability to understand nature and individual consequences of the registry;
* Written informed consent;
* Subjects who are physically or mentally capable of giving consen.

Exclusion Criteria:

\- Severe neurological or psychiatric disorder interfering with the ability to give written informed consent.

Where it's running

• Department of Internal Medicine V, Heidelberg University Hospital
  Heidelberg, Baden-Wurttemberg, Germany Recruiting

Study contacts

• Principal investigator: Prof. Dr. Thomas Luft — Heidelberg University
• Study coordinator: Prof. Dr. Thomas Luft
• Email: Thomas.Luft@med.uni-heidelbe
• Phone: +49 06221/56 8030

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.