Condition

Atherosclerosis clinical trials and research

• 54Clinical trials
• 274NIH research projects
• 26Countries

Newest Atherosclerosis clinical trials

All recruiting trials (54)

• Pudendal artery plaque and erectile dysfunction in men with heart disease

  A small study tests whether plaque in the internal pudendal arteries is linked to erectile function in men with coronary artery disease who are undergoing coronary angiography.

  Recruiting Hospital Central Militar · Mexico City, Mexico City · NCT07856199

• VERVE-102 for adults with or at high risk for heart disease

  This study tests whether VERVE-102 can lower bad cholesterol (LDL-C) compared with a placebo in adults with plaque buildup or high risk for it.

  Recruiting Phase 2 Verve Therapeutics, Inc. · DeSoto, Texas · NCT07839936

• Colchicine for preventing cardiovascular disease in adults with type 2 diabetes

  A 24-week study will test whether low-dose colchicine can help protect blood vessels in adults with type 2 diabetes who have not yet developed artery disease, compared with a placebo.

  Recruiting Phase 2 Tan Tock Seng Hospital · Singapore, Singapore · NCT07837934

• Clazakizumab for adults with high hsCRP at risk for a heart event

  This study tests whether clazakizumab can lower inflammation and reduce cardiovascular risk in adults with high hsCRP and existing risk factors.

  Recruiting at 32 sites Phase 2 Eli Lilly and Company · Huntsville, Alabama and 45 other locations · NCT07783802

• Cilostazol and Aspirin to Prevent Heart and Brain Events in Type 2 Diabetes

  In people with type 2 diabetes and higher cardiovascular risk, researchers are testing whether taking cilostazol plus aspirin can help reduce major heart and brain events.

  Recruiting Phase 4 Seoul National University Bundang Hospital · Seongnam-si, Gyeonggi-do · NCT07719894

• Dapagliflozin to slow coronary plaque progression in type 2 diabetes

  This trial tests whether adding dapagliflozin to standard care can slow or reverse coronary plaque buildup in adults with type 2 diabetes and stable coronary disease.

  Recruiting at 2 sites Phase 4 Chinese PLA General Hospital · Beijing, Beijing Municipality and 1 other locations · NCT07614230

• See if Lepodisiran lowers coronary plaque in people with high Lp(a) and heart disease risk

  This study tests whether lepodisiran can reduce heart-artery plaque in adults with high Lp(a) compared to placebo.

  Recruiting at 53 sites Phase 3 Eli Lilly and Company · La Jolla, California and 56 other locations · NCT07613294

• Moderate-Intensity Statin + Ezetimibe vs High-Intensity Statin in CKD with ASCVD

  In adults with chronic kidney disease and established cardiovascular disease, this study tests whether a moderate-intensity statin plus ezetimibe can match the benefits of a high-intensity statin alone over three years.

  Recruiting Yonsei University · Seoul · NCT07524101

• YN001 in adults with coronary atherosclerosis

  A randomized, placebo-controlled study tests whether IV YN001 can help people with coronary plaque and heart risk factors see if their plaques stabilize or shrink.

  Recruiting at 35 sites Phase 2 Beijing Inno Medicine Co., Ltd. · Huntsville, Alabama and 55 other locations · NCT07521007

• Selnoflast to reduce artery inflammation in people with atherosclerosis at high risk of heart events

  This study will test whether selnoflast can lower artery inflammation in people with atherosclerosis who are at high risk for major heart problems and are already on standard treatments.

  Recruiting at 25 sites Phase 2 Genentech, Inc. · Beverly Hills, California and 24 other locations · NCT07448038

• Software that analyzes heart CT scans to detect coronary artery disease

  This project will test a new software that uses past coronary CT scans to see if it can accurately find blockages and predict which patients might need procedures.

  Recruiting at 4 sites Instituto de Investigación Biomédica de Salamanca · Villeurbanne and 3 other locations · NCT06977295

• IMC-001 injection to improve plaque stability in people with acute coronary syndrome

  This trial will test whether injections of IMC-001, added to standard medical therapy, can improve atherosclerotic plaque stability in adults with acute coronary syndrome.

  Recruiting at 2 sites Early Phase 1 ImmuneOnco Biopharmaceuticals (Shanghai) Inc. · Nanyang, Henan and 1 other locations · NCT06788431

• Investigating body fat distribution and its impact on metabolic diseases in Japanese adults

  This study looks at how the way body fat is distributed affects the risk of metabolic and heart diseases in Japanese adults.

  Recruiting Osaka Metropolitan University · Sakai, Osaka · NCT06694012

• Understanding rare lipid disorders and their effects over time

  This study is trying to understand how rare lipid disorders change over time and how they respond to treatments in people aged 10 and older.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT06676046

• Exercise training for patients with coronary artery disease

  This study tests if a 12-week exercise program can improve heart health for people aged 40-70 with coronary artery disease.

  Recruiting Instituto Nacional de Cardiologia de Laranjeiras · Rio de Janeiro, Rio de Janeiro · NCT06579807

• Using Ferumoxytol for MRI in Atherosclerosis Patients

  This study is testing if Ferumoxytol can be safely used as a contrast agent during MRI scans to help people with atherosclerosis get better images of their blood vessels.

  Recruiting The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School · Nanjing, Jiangsu · NCT06551805

• Single versus dual antiplatelet therapy after drug-coated balloon angioplasty in elderly or high-bleeding-risk patients

  This study tests whether taking one antiplatelet medicine is as safe and causes less bleeding than taking two medicines for people aged 75 or older, or adults at high bleeding risk, after drug-coated balloon angioplasty for coronary artery disease.

  Recruiting Fondazione Ricerca e Innovazione Cardiovascolare ETS · Milan, MI · NCT06535568

• Investigating heart-related side effects of cancer immunotherapy

  This study is testing whether cancer immunotherapy treatments can cause heart problems in patients with certain types of cancer.

  Recruiting Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam, North Holland · NCT06519292

• Cardiovascular risk assessment for patients with lipid disorders in emergency care

  This study is testing a new way to help emergency room patients with high cholesterol lower their heart disease risk by providing better care compared to the usual treatment.

  Recruiting Phase 2 Wake Forest University Health Sciences · Winston-Salem, North Carolina · NCT06488105

• Comparing Clopidogrel and Cilostazol for preventing cardiovascular issues in diabetics

  This study is testing whether the medications Clopidogrel and Cilostazol can help prevent heart problems in adults with type 2 diabetes who have early signs of artery hardening.

  Recruiting Phase 4 Seoul National University Bundang Hospital · Seongnam-si, Gyeonggi-do · NCT06402747

• Understanding sex hormones and inflammation in heart disease

  This study looks at how sex hormones and inflammation affect heart disease in women to better understand their unique risks and improve treatment.

  Recruiting Queen Mary University of London · London · NCT06327984

• Exploring the link between glycoxidation and arterial health in at-risk individuals

  This study looks at how certain changes in the body might affect artery health in people at risk for heart problems to see if they can spot early signs of damage.

  Recruiting Complejo Hospitalario Universitario de Santiago · Santiago de Compostela, A Coruña · NCT06325800

• Examining the TMEM230 gene's role in atherosclerosis

  This study is trying to see how the TMEM230 gene affects atherosclerosis in patients by looking at tissue and blood samples to better understand the condition.

  Recruiting IRCCS Policlinico S. Donato · San Donato Milanese, Milan · NCT06230406

• Assessing Lipoprotein(a) and Fibrinolysis in Heart Disease

  This study is testing whether lowering a specific cholesterol called Lipoprotein(a) with certain medications can help improve the body's ability to dissolve blood clots in people with heart disease.

  Recruiting East and North Hertfordshire NHS Trust · Stevenage · NCT06126367

• Comparing PET/CT and Cardiac CT for Detecting Heart Disease

  This study is testing if a new type of imaging called NaF-PET/CT can find heart disease better than the standard cardiac CT in patients showing symptoms of coronary artery disease.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT05994014

• Comparing morning versus bedtime aspirin for cardiovascular health

  This study is testing if taking aspirin at bedtime works better than taking it in the morning for people who are already using aspirin to protect their heart health.

  Recruiting Phase 4 Herlev and Gentofte Hospital · Hellerup · NCT05932472

• Non-surgical treatment for gum disease's effect on blood vessel health

  This study is testing whether a non-surgical gum treatment can improve blood vessel health in people with gum disease and healthy individuals.

  Recruiting University of Catania · Catania · NCT05906810

• Using air filtration to slow heart disease progression

  This study is testing if using air filters in homes can help slow down heart disease in adults who have had heart problems before.

  Recruiting University of Southern California · Los Angeles, California · NCT05867381

• Research on carotid plaques and their imaging

  This study is trying to find out how to spot dangerous plaques in the arteries that could cause heart attacks or strokes by looking at samples removed during surgery.

  Recruiting Lund University · Malmö, Skåne County · NCT05821894

• Using a smartphone app to improve statin therapy adherence in patients with atherosclerosis

  This study is testing if using a smartphone app to remind people with atherosclerosis to take their statin medication can help them stick to their treatment better than just regular care alone.

  Recruiting University Hospital, Essen · Essen, North Rhine-Westphalia · NCT05777655

• Educational text messages to improve heart health in people with HIV

  This study tests if sending educational text messages can help people over 40 with HIV make better choices for their heart health.

  Recruiting at 2 sites University of California, San Francisco · San Francisco, California and 1 other locations · NCT05642858

• Effects of cannabis on blood vessels

  This study looks at how using cannabis affects blood vessels and inflammation in people who regularly use it compared to those who don’t.

  Recruiting London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · London, Ontario · NCT05581368

• Lowering cholesterol and inflammation in HIV patients using Bempedoic acid

  This study is testing if a medication called Bempedoic acid can lower cholesterol and inflammation in people over 40 with HIV who have heart disease or are at risk for it.

  Recruiting at 3 sites Phase 2 University of California, San Francisco · Los Angeles, California and 2 other locations · NCT05488431

• Using colchicine and ticagrelor to prevent ischemic stroke in patients with atherosclerosis

  This study is testing if a combination of low-dose colchicine and ticagrelor can help prevent future strokes in people with atherosclerosis who have already had an ischemic stroke.

  Recruiting Phase 3 Assistance Publique - Hôpitaux de Paris · Paris, Paris · NCT05476991

• Assessing heart disease risk using carotid ultrasound and stress tests

  This study is testing if combining a special ultrasound of the neck with stress tests can better identify people at risk for serious heart problems over the next three years.

  Recruiting at 5 sites Queen's University · Calgary, Alberta and 5 other locations · NCT05416385

• Combination therapy of atorvastatin and omega-3 for atherosclerosis in type 2 diabetes patients

  This study is testing if combining atorvastatin with omega-3 can help people with type 2 diabetes and early signs of atherosclerosis more than using atorvastatin with another medication.

  Recruiting Phase 4 Seoul National University Bundang Hospital · Seongnam-si, Gyeonggi-do · NCT05365438

• Effect of choline fenofibrate on carotid atherosclerosis in type 2 diabetes patients

  This study is testing if a medication called choline fenofibrate can help slow down the buildup of plaque in the arteries of Korean patients with type 2 diabetes and high cholesterol.

  Recruiting Phase 4 Seoul National University Bundang Hospital · Seongnam-si, Gyeonggi-do · NCT05365425

• Guideline-based lipid lowering approach in Asia-Pacific patients

  This study tests if a special cholesterol management plan helps people in the hospital for a heart attack feel better compared to standard care.

  Recruiting at 11 sites Monash University · Wollongong, New South Wales and 21 other locations · NCT05325034

• Effects of high protein diets on atherosclerosis

  This study is testing how different high protein diets affect the buildup of plaque in the arteries for people aged 45 to 75 who are overweight or obese.

  Recruiting University of Missouri-Columbia · Columbia, Missouri · NCT05235464

• Evaluating long-term outcomes in patients with coronary artery disease

  This study is testing new imaging techniques and assessments to see if they can help doctors better understand and treat patients with coronary artery disease.

  Recruiting Chonnam National University Hospital · Gwangju · NCT05124249

• Sirolimus drug coated balloon treatment for below the knee arterial disease

  This study is testing if a new sirolimus drug-coated balloon can help people with peripheral artery disease have better results than the standard treatment for below the knee arterial problems.

  Recruiting at 17 sites Concept Medical Inc. · Singapore and 19 other locations · NCT04511247

• Sirolimus drug coated balloon for treating artery disease

  This study is testing if a special balloon coated with sirolimus can help people with peripheral artery disease by reducing the chance of their arteries narrowing again compared to regular balloons.

  Recruiting at 17 sites Concept Medical Inc. · Singapore and 19 other locations · NCT04511234

• Mindfulness intervention for reducing vascular inflammation in coronary disease

  This study tests if an 8-week mindfulness program can help reduce inflammation in the blood vessels of adults with stable coronary artery disease who are dealing with high stress.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT04505865

• Evaluating how stress reduction affects heart health

  This study tests if an 8-week program to reduce stress can help improve heart health by lowering inflammation in the arteries for adults dealing with high stress.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT04496947

• Effects of diesel exhaust on inflammation and blood vessels

  This study tests how breathing in diesel exhaust affects the blood vessels and inflammation in healthy people.

  Recruiting at 2 sites University of Athens · Athens, Attica and 1 other locations · NCT04098536

• Registry for cardiometabolic risk factors

  This study is testing how different heart and metabolic health factors affect people to help prevent future heart problems.

  Recruiting Austral University, Argentina · Pilar, Buenos Aires · NCT04040777

• Investigating inflammation's role in vascular disease

  This study is trying to see how low-grade inflammation affects heart and blood vessel problems in patients having vascular surgeries compared to those having other types of surgeries.

  Recruiting Göteborg University · Gothenburg, Vastragotaland · NCT03732612

• Using Metformin to Reduce Heart Risks in Veterans with Prediabetes

  This study tests if the diabetes drug metformin can help reduce the risk of heart attacks, strokes, and death in Veterans with prediabetes and heart disease.

  Recruiting at 37 sites Phase 4 VA Office of Research and Development · Phoenix, Arizona and 39 other locations · NCT02915198

• Using blood biomarkers to assess heart disease risk

  This study is trying to see if certain blood markers can help identify people at risk for heart disease and serious heart problems when they have a routine heart scan.

  Recruiting Maastricht University Medical Center · Maastricht, Limburg · NCT02381301

• New heart imaging techniques to evaluate heart disease

  This study is testing new MRI techniques to see if they can better diagnose heart disease in people who have it, suspect they have it, or are healthy.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT01399385

• Registry for patients with suspected coronary artery disease undergoing CT angiography

  This study is trying to see how helpful a special heart scan is for people suspected of having coronary artery disease in understanding their condition and predicting their health over the next year.

  Recruiting at 10 sites Azienda Ospedaliero-Universitaria di Parma · Milan, MI and 10 other locations · NCT01384721

• Examining how the body responds to endotoxin exposure

  This study is testing how healthy people's immune systems react to a substance called endotoxin by looking at their blood samples to see if it helps us understand links to conditions like asthma and cancer.

  Recruiting National Institutes of Health Clinical Center (CC) · Research Triangle Park, North Carolina · NCT01143480

• Characterizing patients with rare cardiovascular diseases

  This study is trying to learn more about rare heart diseases by testing people who have these conditions, their family members, and healthy volunteers to see how these diseases develop and what causes them.

  Recruiting at 2 sites National Institutes of Health Clinical Center (CC) · Washington D.C., District of Columbia and 2 other locations · NCT01143454

• Understanding the causes and progression of lipid disorders

  This study is trying to understand what causes lipid disorders, like high cholesterol, by looking at people's blood fat levels and genetics to improve how we diagnose and treat these conditions.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT00353782

NIH-funded research (newest 40 of 274)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Coronary disease and immune activation in people with HIV and tuberculosis coinfection

  This research looks at how having HIV and latent tuberculosis together might raise the risk of heart disease, and what immune changes are involved.

  NIH research Emory University · Atlanta, United States · NIH-11618831

• PFAS may speed up artery disease by changing bile acids

  Aims to see if PFAS chemicals make cholesterol rise and arteries more likely to harden, using a human-similar mouse model to understand how this could affect people.

  NIH research Wayne State University · Detroit, United States · NIH-11567374

• IgE antibodies to alpha-gal and heart disease in mice and people

  A study to understand how specific IgE antibodies against alpha-gal might influence the development and severity of atherosclerosis in humans and mouse models.

  NIH research University of Virginia · Charlottesville, United States · NIH-11567002

• Fibroblast Growth Factor 1 to Reduce High Lipids and Plaque in Adults with Diabetes

  A new approach uses a modified FGF1 protein to lower bad cholesterol and prevent artery plaque buildup in adults with Type 2 diabetes, aiming for safer and more effective treatment.

  NIH research University of Arizona · Tucson, United States · NIH-11535001

• Atherosclerosis in cocaine addiction: imaging risk with PET/MR

  This project uses PET/MR imaging to look for early artery disease in people with cocaine use disorder to help prevent strokes or other brain injuries.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11520916

• How low blood flow after brain artery narrowing affects the vessel lining

  This work looks at whether areas of low blood flow downstream of narrowed brain arteries cause vessel lining damage and raise the chance of another stroke, for people with intracranial artery narrowing.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11504591

• Platelet markers and blood flow to predict recurrent stroke in intracranial artery disease

  Researchers will look at how a platelet protein (FcγRIIa) and blood flow patterns from CT angiography predict who might have another stroke after a minor stroke or TIA caused by intracranial artery disease.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11504575

• CD40's role in shaping natural antibody production and atherosclerosis

  This grant tests how immune signals involving CD40 and CD40L influence natural antibody production and plaque development in atherosclerosis.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11458978

• How fat in and around the body affects heart disease and inflammation in diverse groups

  This grant investigates how excess fat storage in places like the liver and around the belly influences inflammation and heart disease risk, especially in South Asian Americans and other populations.

  NIH research Northwestern University · Chicago, United States · NIH-11455106

• Targeting integrin signaling to reduce inflammation in atherosclerosis

  A drug-discovery program aims to reduce inflammatory risk in people with atherosclerosis by interrupting how immune cells communicate through integrins.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11451332

• Role of a vascular smooth muscle cell RNA in protecting against artery disease

  A research grant tests how a specific noncoding RNA in blood vessel cells helps prevent or slow atherosclerosis in people.

  NIH research Augusta University · Augusta, United States · NIH-11450449

• Microglia-derived vesicles and brain-artery inflammation after brain injury

  This NIH grant explores how tiny brain cell packages from microglia after a brain injury may drive inflammation and accelerate artery disease, potentially helping people who’ve had a traumatic brain injury.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11448649

• Estrogen, gut bacteria, and heart health in menopausal hormone therapy

  This study will look at how gut bacteria and estrogen-related recycling affect hot flashes and heart-risk markers in women starting modern menopausal hormone therapy.

  NIH research Albert Einstein College of Medicine · Bronx, United States · NIH-11448536

• Glucose and brain health: how blood sugar and metabolism affect Alzheimer's risk in a diverse group

  This study follows adults 21 and up to see how long-term blood sugar control and metabolic signals relate to the development of Alzheimer's disease and related dementias.

  NIH research Medstar Health Research Institute · Columbia, UNITED STATES · NIH-11448411

• How sleep and exercise may slow a heart disease risk linked to blood cell changes

  This NIH grant explores whether lifestyle choices like sleep and exercise can slow harmful changes in blood cells that raise the risk of atherosclerosis.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11447852

• How SPTLC3 affects aging, diet, and heart disease risk

  This study looks at how a particular enzyme SPTLC3 influences aging-related insulin resistance, fatty liver disease risk, and atherosclerosis, especially when eating a high-fat diet.

  NIH research Suny Downstate Medical Center · Brooklyn, United States · NIH-11446562

• Fortilin inhibitors for a new anti-atherosclerosis therapy

  A new type of small-molecule drug targets fortilin to reduce inflammation and fatty plaque buildup in arteries, offering a potential non-LDL approach for people at risk of heart disease.

  NIH research University of Washington · Seattle, United States · NIH-11445620

• Targeting how macrophages stick to damaged arteries in atherosclerosis

  This grant explores how inflammatory fats create sticky spots in artery walls that trap macrophages, which could worsen atherosclerosis.

  NIH research East Tennessee State University · Johnson City, United States · NIH-11444687

• How the protein EHD1 affects artery plaque inflammation and healing

  Looks at whether changing the activity of a protein called EHD1 can reduce harmful inflammation and help artery plaques heal in people with atherosclerosis.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11442262

• Metabolic clues to why regulatory T cells stop working in atherosclerosis

  This research explores how certain fat-related molecules affect immune cells in arteries to understand why regulatory T cells stop protecting against artery disease.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11432897

• Non-invasive heart fat markers to predict ASCVD risk

  Aging adults who don’t yet have heart disease may get a clearer picture of their risk by using CT scans to study fat around the heart and arteries.

  NIH research Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center · Torrance, United States · NIH-11431415

• Potential Effects of a Plasticizer on Dyslipidemia and Atherosclerosis

  A study in young models looks at how certain plastic chemicals might influence cholesterol and artery disease through a key liver receptor.

  NIH research University of Nebraska Kearney · Kearney, United States · NIH-11422558

• Non-viral gene therapy to treat and prevent atherosclerosis (for patients)

  A small biotechnology study is testing a non-viral DNA delivery method using lipid nanoparticles to help prevent and treat atherosclerosis in adults.

  NIH research Emmune, INC · Juno Beach, UNITED STATES · NIH-11419318

• LGR4 and artery disease in people living with HIV

  This project looks at whether a protein called LGR4 helps drive faster artery plaque buildup in people living with HIV.

  NIH research University of Tennessee Health Sci Ctr · Memphis, United States · NIH-11410450

• A targeted immune therapy against artery disease using a liposome-linked ApoB fragment

  A first-in-class approach aims to train the immune system to fight atherosclerosis by using a tiny ApoB fragment displayed on a liposome to elicit a protective immune response.

  NIH research Pop Biotechnologies, INC · Buffalo, United States · NIH-11409692

• New lipid-lowering and anti-inflammatory siRNA therapy for narrowing ASCVD risk

  A new siRNA treatment is being developed to lower cholesterol production in the liver and reduce artery inflammation to help people with atherosclerotic cardiovascular disease.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11406191

• Fabkin, a New Hormone Complex, and Its Role in Lipids and Inflammation Driving Atherosclerosis

  A new hormone complex called Fabkin is being studied to see if it links fat metabolism and inflammation in atherosclerosis so future treatments could target both problems.

  NIH research Harvard University D/b/a Harvard School of Public Health · Boston, United States · NIH-11406165

• Molecular imaging of artery disease in leg arteries

  A new imaging approach uses a special PET/CT scan to map blood flow and mineral buildup in leg arteries of people with PAD.

  NIH research Research Inst Nationwide Children's Hosp · Columbus, United States · NIH-11404971

• The Role of SECTM1 in Monocyte Biology and Atherosclerosis

  A mentored career development program uses genetic and protein data to better understand how monocytes contribute to atherosclerosis, with findings tested in mouse models.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11399875

• Endothelial SR-BI: How it’s turned on and who it partners with to drive artery plaque

  A study at UT Southwestern will explore how a specific endothelial protein (SR-BI) is turned on in high-cholesterol and stressed blood flow conditions and which partner proteins help it move LDL into artery walls.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11398175

• CD11b's role in helping heart arteries repair themselves

  This NIH grant looks at how a specific immune cell receptor, CD11b, helps or hinders the natural reversal of artery plaque in a mouse model, with potential implications for people with atherosclerosis.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-11395615

• Biological aging in early life: how growth and the environment shape telomere length and early heart disease risk

  This study follows children from birth to young adulthood to see how aging at the cellular level (telomeres) develops and whether it relates to early signs of heart disease.

  NIH research State University of New York at Buffalo · Amherst, United States · NIH-11394631

• Nutrient signals help macrophages clear dead cells to calm inflammation in artery disease

  This grant explores how macrophages eat dead cells in arteries and how that process could slow or stabilize dangerous artery plaques in ASCVD.

  NIH research Louisiana State Univ Hsc Shreveport · Shreveport, United States · NIH-11391151

• Immune checkpoint drugs and faster buildup of heart artery plaques in cancer patients

  This study will follow melanoma patients treated with immune checkpoint inhibitors to see if these cancer drugs speed up coronary artery plaque buildup.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11389288

• IgE against alpha-gal and its role in atherosclerosis in humans and mice

  This study investigates how allergy-related IgE to the sugar alpha-gal may influence coronary artery disease in people and in animal models.

  NIH research University of Virginia · Charlottesville, United States · NIH-11385331

• Endothelial ceramides and protection against coronary artery disease

  This project looks at how certain fats in blood vessel walls influence heart disease and whether they can predict or prevent plaque problems.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11383817

• Screening and treating early heart disease in young and middle-aged adults

  A large study will test the best way to find early artery disease in adults under 50 and whether treating arteries or inflammation helps reduce heart disease risk.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11382099

• Screening and treating early coronary plaque in young and middle-aged adults

  A Duke-led study will test how best to screen for early heart artery plaque in adults under 60 and how different treatments might reduce that plaque.

  NIH research Duke University · Durham, United States · NIH-11382094

• Social factors and fatty liver disease disparities across diverse communities

  A research project will look at how where people live and their social circumstances influence fatty liver disease and why it hits some racial/ethnic groups harder.

  NIH research Drexel University · Philadelphia, United States · NIH-11381709

• Molecular Drivers of Atherosclerosis in Diabetes

  This NIH grant supports research to understand why people with diabetes, especially type 1, have higher heart disease risk and how to prevent it with new ideas grounded in biology.

  NIH research University of Virginia · Charlottesville, United States · NIH-11381041

Related topics

Quick answers

How many Atherosclerosis clinical trials are recruiting right now?

54, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 26 countries. The most sites are in United States (19 trials), South Korea (7 trials), China (5 trials), Italy (4 trials), Singapore (4 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 7, Phase 2: 7, Phase 3: 2, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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