Investigating how spinal cord injuries affect heart health
Official title: Role of Vascular Endothelial Function After Spinal Cord Injury Related Cardiovascular Disease Risk
Run by Craig Hospital · NCT06443151 · Data updated 2026-11-12
This study looks at how spinal cord injuries affect heart health in adults and tries to find out why they may have a higher risk of heart problems.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 89 Years |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Craig Hospital Academic / other |
| Locations | 1 site (Englewood, Colorado) |
| Status | Recruiting |
| Started | September 1, 2024 |
| Main results expected | March 30, 2027 |
| Study ends | March 30, 2027 |
| Registry record updated | August 20, 2024 |
| Trial ID | NCT06443151 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults over 18 years old with a traumatic spinal cord injury, specifically those with paraplegia and a complete motor injury at the T2 level or below.
✕Probably not a fit
Patients with a history of cardiovascular disease, diabetes, or other significant health issues may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study focuses on adults with spinal cord injuries (SCI) and their increased risk of cardiovascular diseases, particularly atherosclerosis. It aims to understand the role of endothelial cell dysfunction in this heightened risk, as traditional risk factors like obesity and diabetes do not fully explain the phenomenon. The study will measure endothelial health through various interventions, including the infusion of vasoactive and antioxidant drugs and the assessment of endothelial microvesicles in the blood. By identifying the mechanisms behind early cardiovascular disease in SCI patients, the study seeks to inform potential therapeutic interventions.
Why it matters
Potential benefit: If successful, this study could lead to improved screening and treatment strategies for cardiovascular disease in individuals with spinal cord injuries.
How similar studies have gone: While there is limited empirical data on endothelial dysfunction in SCI, previous studies suggest that understanding endothelial health could be crucial for addressing cardiovascular risks in this population.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Men and women of all races, ethnic backgrounds\>18 years of age * Traumatic spinal cord injury (Sports, Assault, Transport, Fall, Other Traumatic Causes) * Time since injury (\> 12 months) * Paraplegia Motor Complete Injury (neurological level of injury at T2 or below, ASIA Impairment Scale A or B Exclusion Criteria: * History of high blood pressure * History cardiovascular disease (coronary artery disease, congestive heart failure, myocardial infarction, cerebrovascular accident). * History high cholesterol * History of Diabetes Type I or Type II * History of Obstructive Pulmonary Disease * History of Chronic Kidney or Liver Disease * History of Cancer * History of Autoimmune Disease (Thyroid Disease, Lupus, Rheumatoid Arthritis, etc). * History of smoking tobacco in the last 12 months * History of alcohol use
Where it's running
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Craig Hospital
Englewood, Colorado, United States Recruiting
Study contacts
- Principal investigator: Andrew Park, MD — Craig Hospital
- Study coordinator: Clare Morey, SLP-CCC
- Email: cmorey@craighospital.org
- Phone: 303-789-8621
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.