Endothelial problems and healing after trauma-related blood clotting problems
Official title: Endothelial Dysfunction and Restoration in Trauma Induced Coagulopathy
Funded at University of Pittsburgh at Pittsburgh · NIH-11392317 · Data updated 2026-11-12
This project looks at how blood vessel lining cells contribute to abnormal clotting after severe injury and whether restoring them can improve outcomes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | September 15, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $2,050,867 |
| NIH project number | 5R01HL166944-04 |
| Project ID | NIH-11392317 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients who have suffered severe trauma and are at risk for or have developed trauma-induced coagulopathy.
✕Less likely to help
Patients without severe trauma or with unrelated coagulation conditions may not benefit from these findings.
What this research studies
After severe trauma, many patients develop problems with clotting that can cause both bleeding and dangerous clots. The researchers will study how the inner lining of blood vessels responds to injury and how this response affects the body’s clotting system. They will map the signals that trigger endothelial injury and test how plasma transfusion might help repair the endothelium and normalize coagulation. The goal is to uncover mechanisms and potential targets to reduce death and complications from trauma-induced coagulopathy. This knowledge could guide new therapies to protect patients’ blood vessels and improve recovery.
Why it matters
Potential benefit: Better understanding of how to protect and repair blood vessels after trauma, potentially reducing death and complications from abnormal clotting.
How similar studies have gone: Previous work with plasma transfusion has shown benefits, supporting a potential impact for endothelial repair as part of trauma care.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Neal, Matthew D — University of Pittsburgh at Pittsburgh
- Study coordinator: Neal, Matthew D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.