How platelet stress affects blood vessel function in pulmonary hypertension
Official title: Platelet Metabolic Stress Induces Thrombo-Inflammation to Drive Endothelial Dysfunction in PH
Funded at University of Pittsburgh at Pittsburgh · NIH-10896276 · Data updated 2026-11-12
This study is looking at how platelets, which are tiny cells in your blood, can cause inflammation and damage to blood vessels in people with pulmonary arterial hypertension (PAH), and it hopes to find new ways to help improve blood vessel health for those living with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $706,994 |
| NIH project number | 5R01HL166985-02 |
| Project ID | NIH-10896276 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with pulmonary arterial hypertension who may experience endothelial dysfunction.
✕Less likely to help
Patients with conditions unrelated to pulmonary arterial hypertension or those without endothelial dysfunction may not benefit from this research.
What this research studies
This research investigates the role of platelets in causing inflammation and damage to blood vessels in patients with pulmonary arterial hypertension (PAH). It focuses on understanding how metabolic stress in platelets leads to the activation of inflammatory processes that harm endothelial cells, which line the blood vessels. By studying the mechanisms behind this process, the research aims to identify potential therapeutic targets to improve vascular health in PAH patients. The approach includes analyzing platelet behavior and its effects on endothelial cell function in both laboratory settings and animal models.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reverse blood vessel damage in patients with pulmonary arterial hypertension.
How similar studies have gone: Other research has shown promising results in understanding the role of platelets in vascular diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Shiva, Sruti — University of Pittsburgh at Pittsburgh
- Study coordinator: Shiva, Sruti
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.