How fat cell particles affect blood vessel health in diabetes and the benefits of exercise and surgery
Official title: Role of Adiposomes in Diabetes-Associated Endothelial Dysfunction and Restorative Effects of Exercise and Metabolic Surgery
Funded at University of Illinois at Chicago · NIH-11001122 · Data updated 2026-11-12
This study is looking at how tiny particles from fat cells might cause blood vessel problems in people with obesity-related type II diabetes, and it aims to find out if things like exercise and surgery can help improve blood vessel health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project start | January 1, 2022 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $639,099 |
| NIH project number | 5R01HL161386-04 |
| Project ID | NIH-11001122 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who are diagnosed with obesity-related type II diabetes.
✕Less likely to help
Patients without obesity or type II diabetes may not receive any benefit from this research.
What this research studies
This research investigates how small particles released from fat cells, called adiposomes, contribute to blood vessel problems in individuals with obesity-related type II diabetes. The study aims to understand the molecular mechanisms behind these issues and explore how interventions like exercise and metabolic surgery can help restore healthy blood vessel function. By examining the lipid content of adiposomes and their effects on endothelial cells, the research seeks to identify potential therapeutic strategies for improving vascular health in affected patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve blood vessel function and overall health for patients with obesity-related type II diabetes.
How similar studies have gone: Previous research has shown promising results in understanding the role of adipose tissue in vascular health, suggesting that this approach could yield significant insights.
Where this research is happening
-
University of Illinois at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Mohamed, Abeer M — University of Illinois at Chicago
- Study coordinator: Mohamed, Abeer M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.