Investigating how a specific protein modification affects blood vessel health and heart disease.
Official title: Role of protein-S-glutathionylation in endothelial dysfunction and atherosclerosis
Funded at Boston University Medical Campus · NIH-10551314 · Data updated 2026-11-12
This study is looking at how a specific change in a protein might cause problems in blood vessels that can lead to heart disease, and it's aimed at finding new ways to help improve heart health for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | February 4, 2020 |
| Project end | January 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $412,500 |
| NIH project number | 5R01HL137771-04 |
| Project ID | NIH-10551314 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who are at risk for or suffering from atherosclerosis or related cardiovascular conditions.
✕Less likely to help
Patients with non-cardiovascular related conditions or those under 21 years old may not receive benefit from this research.
What this research studies
This research focuses on understanding the role of a protein modification called S-glutathionylation in the dysfunction of blood vessels, which can lead to heart disease. The study aims to explore how this modification affects a key protein, Rac1, which is crucial for maintaining healthy blood vessel function. By examining the mechanisms behind Rac1's signaling and its relationship with oxidative stress, the researchers hope to identify new therapeutic strategies to reverse endothelial dysfunction and atherosclerosis. Patients may benefit from insights that could lead to innovative treatments for cardiovascular diseases.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve blood vessel function and reduce the risk of heart disease.
How similar studies have gone: Previous research has shown promising results in targeting similar pathways for improving vascular health, indicating potential for success in this approach.
Where this research is happening
-
Boston University Medical Campus
Boston, United States Active
Researchers
- Principal investigator: Han, Jingyan — Boston University Medical Campus
- Study coordinator: Han, Jingyan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.