Investigating the role of fat cells in heart disease for people with type 1 diabetes
Single-cell, multi-omic investigation of epicardial adipose and coronary endothelial dysfunction in type 1 diabetes
This study is looking at how fat cells around the heart might play a role in heart disease for people with type 1 diabetes, and it aims to find out what changes happen in these cells that could lead to heart problems.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11074419 on NIH RePORTER |
What this research studies
This research focuses on understanding how fat cells around the heart, known as epicardial adipose tissue, contribute to heart disease in individuals with type 1 diabetes. By analyzing samples from a specialized tissue bank, the study aims to identify specific cellular changes and inflammatory signals that may lead to coronary artery dysfunction. The researchers will use advanced techniques to profile these cells at a single-cell level and explore how diabetes affects their function. Ultimately, the goal is to uncover the mechanisms behind heart disease in type 1 diabetes and identify potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with type 1 diabetes, particularly those experiencing cardiovascular issues.
Not a fit: Patients without type 1 diabetes or those with other unrelated cardiovascular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating heart disease in patients with type 1 diabetes.
How similar studies have performed: Previous research has shown promising results in understanding the role of adipose tissue in cardiovascular diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Majithia, Amit — University of California, San Diego
- Study coordinator: Majithia, Amit
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.