Non-surgical treatment for gum disease's effect on blood vessel health
Official title: Impact of Non-surgical Periodontal Therapy in the Improvement of Early Endothelial Dysfunction in Subjects With Peri-implantitis and Peri-implant Mucositis: a Randomized-controlled Clinical Trial.
Run by University of Catania · NCT05906810 · Data updated 2026-11-12
This study is testing whether a non-surgical gum treatment can improve blood vessel health in people with gum disease and healthy individuals.
Quick facts
| Study type | Interventional |
|---|---|
| Sex | All |
| Enrollment | 90 (estimated) |
| Sponsor | University of Catania Academic / other |
| Locations | 1 site (Catania) |
| Status | Recruiting |
| Started | October 5, 2020 |
| Main results expected | November 20, 2025 |
| Study ends | December 20, 2025 |
| Registry record updated | May 21, 2025 |
| Trial ID | NCT05906810 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals diagnosed with peri-implantitis or peri-implant mucositis without a history of cardiovascular disease.
✕Probably not a fit
Patients with a history of cardiovascular diseases or those who have undergone recent periodontal treatments will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial evaluates the effects of non-surgical periodontal treatment on endothelial dysfunction in patients with peri-implantitis and peri-implant mucositis, as well as healthy controls. It involves a double-blind randomized-controlled design with 90 participants divided into three groups: those with peri-implantitis, those with peri-implant mucositis, and healthy individuals. Clinical assessments, blood tests, and non-invasive ultrasound cardiovascular measurements are conducted before and after treatment to determine the impact of the intervention.
Why it matters
Potential benefit: If successful, this treatment could improve vascular health in patients with gum disease, potentially reducing cardiovascular risks.
How similar studies have gone: While similar studies have explored the relationship between periodontal health and cardiovascular conditions, this specific approach is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
PERI-IMPLANTITIS GROUP Inclusion Criteria: • Clinically diagnosed with peri-implantitis according to the EFP/AAP 2017 criteria. Exclusion Criteria: * Periodontal treatment, implant surgery, antibiotics, NSAIDs, immunosuppressants during the last 6 months. * Pregnancy. * Cardiovascular Diseases. PERI-IMPLANT MUCOSITIS GROUP Inclusion Criteria: • Clinically diagnosed with peri-implant mucositis according to the EFP/AAP 2017 criteria. Exclusion Criteria: * Periodontal treatment, implant surgery, antibiotics, NSAIDs, immunosuppressants during the last 6 months. * Pregnancy. * Cardiovascular Diseases. HEALTHY GROUP Inclusion Criteria: • Clinically diagnosed with healthy periodontum withouth periodontitis history according to the EFP/AAP 2017 criteria. Exclusion Criteria: * Scaling, antibiotics, NSAIDs, immunosuppressants during the last 6 months. * Pregnancy. * Cardiovascular Diseases.
Where it's running
-
AOU Policlinico G. Rodolico
Catania, Italy Recruiting
Study contacts
- Study coordinator: Gaetano Isola, PhD
- Email: gaetano.isola@unict.it
- Phone: +39-095-378-2453
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.